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公开(公告)号：US07642276B2
公开(公告)日：2010-01-05
申请号：US10522955
申请日：2003-07-30
申请人： Richard Martyn Angell , Ian Robert Baldwin , Paul Bamborough , Nigel Marc Deboeck , Timothy Longstaff , Stephen Swanson
发明人： Richard Martyn Angell , Ian Robert Baldwin , Paul Bamborough , Nigel Marc Deboeck , Timothy Longstaff , Stephen Swanson
IPC分类号： A61K31/423 , A61K31/404 , A61K31/428 , A61K31/496 , A61K31/5377 , A61K31/4025 , A61K31/341 , A61K31/381 , C07D403/04 , C07D261/20 , C07D277/62 , C07D413/04
CPC分类号： C07D413/14 , C07D231/56 , C07D261/20 , C07D277/82 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Compounds of formula (I): wherein A is a 5-membered heteroaryl ring are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38, such as rheumatoid arthritis.
摘要翻译： 式（I）化合物：其中A是5元杂芳基环是p38激酶的抑制剂，并且可用于治疗由p38激酶活性介导的或由p38活性产生的细胞因子介导的病状或疾病状态，例如 类风湿关节炎。
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2.发明申请Indole Derivatives and Use Thereof as Kinase Inhibitors in Particular Ikk2 Inhibitors 审中-公开吲哚衍生物及其用途作为特异性Ikk2抑制剂中的激酶抑制剂公开(公告)号：US20080269200A1
公开(公告)日：2008-10-30
申请号：US10597154
申请日：2005-01-13
申请人： Ian Robert Baldwin , Paul Bamborough , John Andrew Christopher , Jeffrey K Kerns , Timothy Longstaff , David Drysdale Miller
发明人： Ian Robert Baldwin , Paul Bamborough , John Andrew Christopher , Jeffrey K Kerns , Timothy Longstaff , David Drysdale Miller
IPC分类号： A61K31/55 , C07D209/04 , C07D401/04 , C07D405/04 , C07D403/04 , A61P37/02 , A61K31/404 , A61K31/506 , A61K31/4439
CPC分类号： C07D413/04 , C07D209/08 , C07D401/04 , C07D401/06 , C07D403/04 , C07D405/04 , C07D409/04 , C07D409/14
摘要： Indole carboxamide compounds of Formula (I): are provided as inhibitors of kinase activity, in particular IKK2 activity as well as compositions and medicaments containing them, for use in inflammatory and tissue repair disorders.
摘要翻译： 提供式（I）的吲哚羧酰胺化合物：作为激酶活性的抑制剂，特别是IKK2活性以及含有它们的组合物和药物，用于炎性和组织修复障碍。
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3.发明申请公开(公告)号：US20060089393A1
公开(公告)日：2006-04-27
申请号：US10513095
申请日：2003-04-29
申请人： Richard Angell , Paul Bamborough , Ian Baldwin , Anne-Marie Li-Kwai-Cheung , Timothy Longstaff , Suzanne Merrick , Kathryn Smith , Stephen Swanson , Ann Walker
发明人： Richard Angell , Paul Bamborough , Ian Baldwin , Anne-Marie Li-Kwai-Cheung , Timothy Longstaff , Suzanne Merrick , Kathryn Smith , Stephen Swanson , Ann Walker
IPC分类号： A61K31/44 , A61K31/40 , A61K31/277 , A61K31/165 , C07D207/04
CPC分类号： C07D207/325 , C07D231/12 , C07D233/64 , C07D249/14 , C07D257/04 , C07D271/06 , C07D271/10 , C07D271/113 , C07D277/40 , C07D413/04 , C07D413/12 , C07D417/12
摘要： Compounds of formula (I) are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
摘要翻译： 式（I）化合物是p38激酶的抑制剂，可用于治疗由p38激酶活性介导的或由p38活性产生的细胞因子介导的病状或疾病状态。
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4.发明授权公开(公告)号：US07425555B2
公开(公告)日：2008-09-16
申请号：US10513095
申请日：2003-04-29
申请人： Richard Martyn Angell , Paul Bamborough , Ian Robert Baldwin , Anne-Marie Li-Kwai-Cheung , Timothy Longstaff , Suzanne Joy Merrick , Kathryn Jane Smith , Stephen Swanson , Ann Louise Walker
发明人： Richard Martyn Angell , Paul Bamborough , Ian Robert Baldwin , Anne-Marie Li-Kwai-Cheung , Timothy Longstaff , Suzanne Joy Merrick , Kathryn Jane Smith , Stephen Swanson , Ann Louise Walker
IPC分类号： A61K31/5377 , C07D413/12
CPC分类号： C07D207/325 , C07D231/12 , C07D233/64 , C07D249/14 , C07D257/04 , C07D271/06 , C07D271/10 , C07D271/113 , C07D277/40 , C07D413/04 , C07D413/12 , C07D417/12
摘要： Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
摘要翻译： 式（I）化合物：p38激酶的抑制剂，可用于治疗由p38激酶活性介导的或由p38活性产生的细胞因子介导的病状或疾病状态。
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5.发明申请Fused heteroaryl derivatives for use as p38 kinase inhibitors in the treatment of i.a. rheumatoid arthristis 失效用作p38激酶抑制剂的稠合杂芳族衍生物用于治疗i.a. 类风湿关节炎公开(公告)号：US20060122221A1
公开(公告)日：2006-06-08
申请号：US10522955
申请日：2003-07-30
申请人： Richard Angell , Ian Baldwin , Paul Bamborough , Nigel Deboeck , Timothy Longstaff , Stephen Swanson
发明人： Richard Angell , Ian Baldwin , Paul Bamborough , Nigel Deboeck , Timothy Longstaff , Stephen Swanson
IPC分类号： A61K31/47 , C07D209/18 , A61K31/405
CPC分类号： C07D413/14 , C07D231/56 , C07D261/20 , C07D277/82 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Compounds of formula (I): wherein A is a 5-membered heteroaryl ring are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38, such as rheumatoid arthritis.
摘要翻译： 式（I）化合物：其中A是5元杂芳基环是p38激酶的抑制剂，可用于治疗由p38激酶活性介导的或由p38活性产生的细胞因子介导的病状或疾病状态，例如 类风湿关节炎。
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