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    Chemical compounds
    1.
    发明授权
    Chemical compounds 失效

    公开(公告)号：US5023255A

    公开(公告)日：1991-06-11

    申请号：US493250

    申请日：1990-03-14

    申请人： Frank Ellis ,  Alan Naylor ,  Christopher J. Wallis ,  Ian Waterhouse

    发明人： Frank Ellis ,  Alan Naylor ,  Christopher J. Wallis ,  Ian Waterhouse

    IPC分类号： C12N9/99 ,  A61K31/53 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07C281/02 ,  C07C281/06 ,  C07D233/64 ,  C07D253/06 ,  C07D281/02 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12

    CPC分类号： C07D253/06

    摘要： Triazine derivatives of formula (I) ##STR1## or salts thereof, whereinR.sup.1 represents a halogen atom or a group selected from hydroxy; C.sub.1-8 alkyl C.sub.1-6 alkoxy; C.sub.1-3 alkoxy C.sub.1-3 alkoxy; phenoxy or phenyl C.sub.1-3 alkoxy, wherein the phenyl group is optionally substituted by a halogen atom or a group selected from C.sub.1-3 alkyl, C.sub.1-3 alkoxy, or hydroxy; fluoro C.sub.1-3 alkyl; cyano; --CO.sub.2 R.sup.3, wherein R.sup.3 represents a hydrogen atom or a C.sub.1-4 alkyl group; --CONR.sup.4 R.sup.5, wherein R.sup.4 and R.sup.5 each independently represents a hydrogen atom or a C.sub.1-4 alkyl group, or, together with the nitrogen atom to which they are attached, form a saturated 5- to 7- membered ring, which ring optionally contains one or more atoms selected from an oxygen or a sulphur atom, or a group selected from --NH-- or --N(CH.sub.3)--; andR.sup.2 represents a hydrogen or halogen atom, or a group selected from hydroxy, C.sub.1-6 alkyl or C.sub.1-6 alkoxy;are inhibitors of the enzyme 5-lipoxygenase.Processes for preparing the triazine derivatives of formula (I) and compositions containing them are also described.

    Triazine derivatives
    2.
    发明授权
    Triazine derivatives 失效
    三嗪衍生物

    公开(公告)号：US4985427A

    公开(公告)日：1991-01-15

    申请号：US344667

    申请日：1989-04-28

    申请人： Ian Waterhouse ,  Alan Naylor ,  Christopher J. Wallis ,  Frank Ellis

    发明人： Ian Waterhouse ,  Alan Naylor ,  Christopher J. Wallis ,  Frank Ellis

    IPC分类号： A61K31/53 ,  A61P43/00 ,  C07C67/00 ,  C07C241/00 ,  C07C243/22 ,  C07C255/66 ,  C07C281/06 ,  C07D253/06

    CPC分类号： C07D253/06

    摘要： Compounds of formula (I) ##STR1## wherein R.sup.1 is selected from the group consisting of hydrogen, halogen, hydroxy, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, phenylC.sub.1-3 alkoxy (in which the phenyl group is optionally substituted by a substituent selected from halogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy and hydroxy), nitro, trifluoromethyl, cyano, --CO.sub.2 R.sup.3 (wherein R.sup.3 is selected from hydrogen and C.sub.1-4 alkyl) and --CONR.sup.4 R.sup.5 (wherein R.sup.4 and R.sup.5 are each independently selected from hydrogen and C.sub.1-4 alkyl, or R.sup.4 and R.sup.5 together with the nitrogen atom to which they are attached form a saturated 5- to 7- membered ring, which ring optionally contains one or more groups or atoms selected from oxygen, sulphur, --NH-- and --N(CH.sub.3)--); and R.sup.2 is selected from the group consisting of hydrogen, halogen, hydroxy, C.sub.1-6 alkyl and C.sub.1-6 alkoxy; and salts thereof are inhibitors of the enzyme 5-lipoxygenase.Processes for preparing the compounds of formula (I) and compositions containing them are also described.