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公开(公告)号：US20110117135A1
公开(公告)日：2011-05-19
申请号：US12876830
申请日：2010-09-07
IPC分类号： A61K39/00 , C12N5/0784 , C12N5/071 , A61P37/04 , A61P35/00
CPC分类号： C12N5/0639 , C12N5/064 , C12N2506/02
摘要： This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. Culture of the myeloid precursor cells with the cytokines GM-CSF and IL-4 causes functional dendritic cells to be generated. The dendritic cells have a unique phenotype, as indicated by their combination of cell surface markers.
摘要翻译： 本发明涉及来自人胚胎干（ES）细胞的树突状细胞的培养。 首先通过与基质细胞共培养将人类ES细胞培养成造血细胞。 然后将分化成造血谱系的细胞与GM-CSF一起培养以产生骨髓前体细胞的培养物。 用细胞因子GM-CSF和IL-4培养骨髓前体细胞会导致产生功能性树突状细胞。 树突细胞具有独特的表型，如细胞表面标志物的组合所示。
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公开(公告)号：US07811821B2
公开(公告)日：2010-10-12
申请号：US11443608
申请日：2006-05-31
CPC分类号： C12N5/0639 , C12N5/064 , C12N2506/02
摘要： This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. Culture of the myeloid precursor cells with the cytokines GM-CSF and IL-4 causes functional dendritic cells to be generated. The dendritic cells have a unique phenotype, as indicated by their combination of cell surface markers.
摘要翻译： 本发明涉及来自人胚胎干（ES）细胞的树突状细胞的培养。 首先通过与基质细胞共培养将人类ES细胞培养成造血细胞。 然后将分化成造血谱系的细胞与GM-CSF一起培养以产生骨髓前体细胞的培养物。 用细胞因子GM-CSF和IL-4培养骨髓前体细胞会导致产生功能性树突状细胞。 树突细胞具有独特的表型，如细胞表面标志物的组合所示。
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3.发明授权公开(公告)号：US08133732B2
公开(公告)日：2012-03-13
申请号：US12876830
申请日：2010-09-07
CPC分类号： C12N5/0639 , C12N5/064 , C12N2506/02
摘要： This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. Culture of the myeloid precursor cells with the cytokines GM-CSF and IL-4 causes functional dendritic cells to be generated. The dendritic cells have a unique phenotype, as indicated by their combination of cell surface markers.
摘要翻译： 本发明涉及来自人胚胎干（ES）细胞的树突状细胞的培养。 首先通过与基质细胞共培养将人类ES细胞培养成造血细胞。 然后将分化成造血谱系的细胞与GM-CSF一起培养以产生骨髓前体细胞的培养物。 用细胞因子GM-CSF和IL-4培养骨髓前体细胞会导致产生功能性树突状细胞。 树突细胞具有独特的表型，如细胞表面标志物的组合所示。
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公开(公告)号：US20120142106A1
公开(公告)日：2012-06-07
申请号：US13364074
申请日：2012-02-01
IPC分类号： C12N5/0784 , C12N15/07
CPC分类号： C12N5/0639 , C12N5/064 , C12N2506/02
摘要： This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. Culture of the myeloid precursor cells with the cytokines GM-CSF and IL-4 causes functional dendritic cells to be generated. The dendritic cells have a unique phenotype, as indicated by their combination of cell surface markers.
摘要翻译： 本发明涉及来自人胚胎干（ES）细胞的树突状细胞的培养。 首先通过与基质细胞共培养将人类ES细胞培养成造血细胞。 然后将分化成造血谱系的细胞与GM-CSF一起培养以产生骨髓前体细胞的培养物。 用细胞因子GM-CSF和IL-4培养骨髓前体细胞会导致产生功能性树突状细胞。 树突细胞具有独特的表型，如细胞表面标志物的组合所示。
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5.发明授权Erythroid cells producing adult-type β-hemoglobin generated from human embryonic stem cells 有权由人胚胎干细胞产生的产生成人型和血红蛋白的红细胞公开(公告)号：US08158422B2
公开(公告)日：2012-04-17
申请号：US11672724
申请日：2007-02-08
CPC分类号： C12N5/0641 , C12N2500/25 , C12N2501/125 , C12N2501/14 , C12N2501/145 , C12N2501/23 , C12N2501/39 , C12N2502/1394 , C12N2506/02
摘要： Methods and compositions of erythroid cells that produce adult β-hemoglobin, generated by culturing CD31+, CD31+/CD34+ or CD34+ cells from embryonic stem cells under serum-free culture conditions.
摘要翻译： 通过在无血清培养条件下培养来自胚胎干细胞的CD31 +，CD31 + / CD34 +或CD34 +细胞产生成人和血红蛋白的红细胞的方法和组合物。
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6.发明申请ERYTHROID CELLS PRODUCING ADULT-TYPE BETA-HEMOGLOBIN GENERATED FROM HUMAN EMBRYONIC STEM CELLS 审中-公开生产来自人胚胎干细胞的成年型β-氨基丁糖的ERYTHROID细胞公开(公告)号：US20140248699A1
公开(公告)日：2014-09-04
申请号：US13419055
申请日：2012-03-13
IPC分类号： C12N5/078
CPC分类号： C12N5/0641 , C12N2500/25 , C12N2501/125 , C12N2501/14 , C12N2501/145 , C12N2501/23 , C12N2501/39 , C12N2502/1394 , C12N2506/02
摘要： Methods and compositions of erythroid cells that produce adult β-hemoglobin, generated by culturing CD31+, CD31+/CD34+ or CD34+ cells from embryonic stem cells under serum-free culture conditions.
摘要翻译： 通过在无血清培养条件下培养来自胚胎干细胞的CD31 +，CD31 + / CD34 +或CD34 +细胞产生成人和血红蛋白的红细胞的方法和组合物。
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公开(公告)号：US08435785B2
公开(公告)日：2013-05-07
申请号：US13364074
申请日：2012-02-01
CPC分类号： C12N5/0639 , C12N5/064 , C12N2506/02
摘要： This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. Culture of the myeloid precursor cells with the cytokines GM-CSF and IL-4 causes functional dendritic cells to be generated. The dendritic cells have a unique phenotype, as indicated by their combination of cell surface markers.
摘要翻译： 本发明涉及来自人胚胎干（ES）细胞的树突状细胞的培养。 首先通过与基质细胞共培养将人类ES细胞培养成造血细胞。 然后将分化成造血谱系的细胞与GM-CSF一起培养以产生骨髓前体细胞的培养物。 用细胞因子GM-CSF和IL-4培养骨髓前体细胞会导致产生功能性树突状细胞。 树突细胞具有独特的表型，如细胞表面标志物的组合所示。
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公开(公告)号：US20120040362A1
公开(公告)日：2012-02-16
申请号：US13194623
申请日：2011-07-29
CPC分类号： C12N5/0647 , C12N2502/1394 , C12N2506/02
摘要： This invention relates to hematopoietic precursors derived from human embryonic stem cells. In the culture of differentiated cells from human ES cells, the fully committed hematopoietic precursors are CD34+ and CD43+ but not CD45+. If the cells are cultured until they express CD45, then the cells lose the ability to produce differentiated cells of the lymphoid lineages.
摘要翻译： 本发明涉及衍生自人胚胎干细胞的造血前体。 在来自人ES细胞的分化细胞的培养物中，完全致命的造血前体是CD34 +和CD43 +而不是CD45 +。 如果细胞培养直到它们表达CD45，则细胞失去产生淋巴系谱系的分化细胞的能力。
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9.发明申请GENERATION OF CLONAL MESENCHYMAL PROGENITORS AND MESENCHYMAL STEM CELL LINES UNDER SERUM-FREE CONDITIONS 有权在无血清条件下产生骨髓间充质干细胞和细胞干细胞细胞系公开(公告)号：US20090081784A1
公开(公告)日：2009-03-26
申请号：US12024770
申请日：2008-02-01
IPC分类号： C12N5/06
CPC分类号： C12N5/0662 , C12N2500/90 , C12N2501/115 , C12N2502/1394 , C12N2506/02 , C12N2510/00 , C12N2799/027
摘要： Methods for obtaining multipotent mesenchymal stem cells under serum-free conditions and methods for identifying multipotent mesenchymal progenitor cells are disclosed.
摘要翻译： 公开了在无血清条件下获得多能间充质干细胞的方法和用于鉴定多能间充质祖细胞的方法。
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公开(公告)号：US09624470B2
公开(公告)日：2017-04-18
申请号：US13194623
申请日：2011-07-29
IPC分类号： C12N5/0789 , C12N5/071 , G01N33/53
CPC分类号： C12N5/0647 , C12N2502/1394 , C12N2506/02
摘要： This invention relates to hematopoietic precursors derived from human embryonic stem cells. In the culture of differentiated cells from human ES cells, the fully committed hematopoietic precursors are CD34+ and CD43+ but not CD45+. If the cells are cultured until they express CD45, then the cells lose the ability to produce differentiated cells of the lymphoid lineages.
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