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公开(公告)号：US08278277B2
公开(公告)日：2012-10-02
申请号：US12420896
申请日：2009-04-09
IPC分类号： A61K38/08
CPC分类号： A61K47/48046 , A61K47/186 , A61K47/36 , A61K47/48853 , A61K47/48907 , A61K47/543 , A61K47/6921 , A61K47/6935 , Y10S977/773 , Y10S977/788 , Y10S977/915
摘要： Compositions comprising a lipophilic derivative of a hydrophilic drug and an amphiphile compound for use in therapy of the human or animal body are provided. Methods of medical treatment, wherein a composition according to the invention is administered to a human or animal body also form part of the invention. It is preferred that the drug is delivered to the brain.
摘要翻译： 提供了包含亲水性药物的亲脂性衍生物和用于人或动物体的治疗的两亲化合物的组合物。 医疗方法，其中根据本发明的组合物施用于人或动物体也构成本发明的一部分。 优选将药物输送到脑中。
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公开(公告)号：US08920819B2
公开(公告)日：2014-12-30
申请号：US13601125
申请日：2012-08-31
IPC分类号： A61P25/00 , A61P25/04 , A61P25/18 , A61P25/28 , A61K9/14 , A61P3/04 , B82Y5/00 , A61K47/48 , A61K47/18 , A61K47/36
CPC分类号： A61K47/48046 , A61K47/186 , A61K47/36 , A61K47/48853 , A61K47/48907 , A61K47/543 , A61K47/6921 , A61K47/6935 , Y10S977/773 , Y10S977/788 , Y10S977/915
摘要： Compositions comprising a lipophilic derivative of a hydrophilic drug and an amphiphile compound for use in therapy of the human or animal body are provided. Methods of medical treatment, wherein a composition according to the invention is administered to a human or animal body also form part of the invention. It is preferred that the drug is delivered to the brain.
摘要翻译： 提供了包含亲水性药物的亲脂性衍生物和用于人或动物体的治疗的两亲化合物的组合物。 医疗方法，其中根据本发明的组合物施用于人或动物体也构成本发明的一部分。 优选将药物输送到脑中。
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公开(公告)号：US20130034590A1
公开(公告)日：2013-02-07
申请号：US13601125
申请日：2012-08-31
CPC分类号： A61K47/48046 , A61K47/186 , A61K47/36 , A61K47/48853 , A61K47/48907 , A61K47/543 , A61K47/6921 , A61K47/6935 , Y10S977/773 , Y10S977/788 , Y10S977/915
摘要： Compositions comprising a lipophilic derivative of a hydrophilic drug and an amphiphile compound for use in therapy of the human or animal body are provided. Methods of medical treatment, wherein a composition according to the invention is administered to a human or animal body also form part of the invention. It is preferred that the drug is delivered to the brain.
摘要翻译： 提供了包含亲水性药物的亲脂性衍生物和用于人或动物体的治疗的两亲化合物的组合物。 医疗方法，其中根据本发明的组合物施用于人或动物体也构成本发明的一部分。 优选将药物输送到脑中。
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公开(公告)号：US20100222281A1
公开(公告)日：2010-09-02
申请号：US12420896
申请日：2009-04-09
CPC分类号： A61K47/48046 , A61K47/186 , A61K47/36 , A61K47/48853 , A61K47/48907 , A61K47/543 , A61K47/6921 , A61K47/6935 , Y10S977/773 , Y10S977/788 , Y10S977/915
摘要： Compositions comprising a lipophilic derivative of a hydrophilic drug and an amphiphile compound for use in therapy of the human or animal body are provided. Methods of medical treatment, wherein a composition according to the invention is administered to a human or animal body also form part of the invention. It is preferred that the drug is delivered to the brain.
摘要翻译： 提供了包含亲水性药物的亲脂性衍生物和用于人或动物体的治疗的两亲化合物的组合物。 医疗方法，其中根据本发明的组合物施用于人或动物体也构成本发明的一部分。 优选将药物输送到脑中。
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公开(公告)号：US20060148982A1
公开(公告)日：2006-07-06
申请号：US10528602
申请日：2003-09-22
申请人： Ijeoma Uchegbu , Andreas Schatzlein , Woei Cheng
发明人： Ijeoma Uchegbu , Andreas Schatzlein , Woei Cheng
CPC分类号： C08G73/0213 , A61K9/2031 , A61K47/34 , C08G73/0206 , C08G73/0226
摘要： This invention relates to the delivery of drugs. In particular, this invention relates to the oral delivery of poorly soluble drugs using novel amphiphilic polymers with both solubilising and absorption enhancing properties.
摘要翻译： 本发明涉及药物的递送。 特别地，本发明涉及使用具有增溶和吸收增强性质的新型两亲性聚合物口服递送难溶性药物。
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公开(公告)号：US20130203647A1
公开(公告)日：2013-08-08
申请号：US13809374
申请日：2011-07-11
IPC分类号： A61K47/48
CPC分类号： A61K47/48046 , A61K9/0019 , A61K9/0092 , A61K9/08 , A61K38/00 , A61K47/542 , A61K47/543 , A61K47/549
摘要： A composition comprises nanofibres for the delivery of a peptide across the blood brain barrier in a method of therapy of the human or animal body, wherein the nanofibres comprise a peptide conjugated to a lipophilic group. Further, a compound comprises a Dalargin or a derivative having one or more substituted, deleted or inserted aminoacyl units, and, conjugated to an aminoacyl group preferably via a side chain, a lipophilic group, optionally via a linker.
摘要翻译： 组合物包含用于在人或动物体的治疗方法中跨越血脑屏障递送肽的纳米纤维，其中所述纳米纤维包含与亲脂基团缀合的肽。 此外，化合物包含达尔加因或具有一个或多个取代，缺失或插入的氨基单元的衍生物，并且优选通过侧链与亲酰基团任选地经由接头缀合至氨酰基。
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7.发明授权公开(公告)号：US07741474B2
公开(公告)日：2010-06-22
申请号：US10528603
申请日：2003-09-22
CPC分类号： C08B37/003 , A61K9/2031 , A61K47/34
摘要： This invention relates to novel carbohydrate polymers with hydrophobic and hydrophilic side-groups suitable for solubilising, for example, hydrophobic drugs. The chain length of the carbohydrate polymeric backbone, and the type and number of the hydrophobic and hydrophilic side-groups are specifically chosen to improve the solubility properties of the carbohydrate polymers.
摘要翻译： 本发明涉及具有疏水和亲水侧基的新型碳水化合物聚合物，其适用于增溶例如疏水性药物。 碳水化合物聚合物主链的链长以及疏水和亲水侧基的类型和数量被特别地选择以改善碳水化合物聚合物的溶解性质。
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8.发明申请公开(公告)号：US20060167116A1
公开(公告)日：2006-07-27
申请号：US10528603
申请日：2003-09-22
CPC分类号： C08B37/003 , A61K9/2031 , A61K47/34
摘要： This invention relates to novel carbohydrate polymers with hydrophobic and hydrophilic side-groups suitable for solubilising, for example, hydrophobic drugs. The chain length of the carbohydrate polymeric backbone, and the type and number of the hydrophobic and hydrophilic side-groups are specifically chosen to improve the solubility properties of the carbohydrate polymers.
摘要翻译： 本发明涉及具有疏水和亲水侧基的新型碳水化合物聚合物，其适用于增溶例如疏水性药物。 碳水化合物聚合物主链的链长以及疏水和亲水侧基的类型和数量被特别地选择以改善碳水化合物聚合物的溶解性质。
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公开(公告)号：US20050019923A1
公开(公告)日：2005-01-27
申请号：US10493125
申请日：2002-10-17
IPC分类号： A61K47/30 , A61K31/7088 , A61K38/00 , A61K47/34 , A61K47/48 , A61P1/16 , A61P35/00 , A61K48/00 , C12N15/85
CPC分类号： B82Y5/00 , A61K47/6885 , A61K47/6891 , C08L101/005
摘要： The present invention provides cationic dendrimers for delivering bioactive molecules, such as polynucleotide molecules, peptides and polypeptides and/or pharmaceutical agents, to a mammalian body. The dendrimers disclosed herein are suitable for targeting the delivery of the bioactive molecules to, for example, the liver, spleen, lung, kidney or heart.
摘要翻译： 本发明提供了用于将生物活性分子（例如多核苷酸分子，肽和多肽和/或药剂）递送至哺乳动物体的阳离子树枝状大分子。 本文公开的树枝状大分子适用于将生物活性分子递送至例如肝，脾，肺，肾或心脏。
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公开(公告)号：US20080267903A1
公开(公告)日：2008-10-30
申请号：US11577339
申请日：2005-10-14
IPC分类号： A61K31/785 , A61P35/00
CPC分类号： A61K31/785
摘要： Various polymers, including cationic polyamine polymers and dendrimeric polymers, are shown to possess anti-proliferative activity, and may therefore be useful for treatment of disorders characterised by undesirable cellular proliferation such as neoplasms and tumours, inflammatory disorders (including autoimmune disorders), psoriasis and atherosclerosis. The polymers may be used alone as active agents, or as delivery vehicles for other therapeutic agents, such as drug molecules or nucleic acids for gene therapy. In such cases, the polymers' own intrinsic anti-tumour activity may complement the activity of the agent to be delivered.
摘要翻译： 显示各种聚合物，包括阳离子聚胺聚合物和树枝状聚合物聚合物，其具有抗增殖活性，因此可用于治疗特征在于不期望的细胞增殖如赘生物和肿瘤，炎性疾病（包括自身免疫性疾病），银屑病和 动脉粥样硬化。 聚合物可以单独使用作为活性剂，或作为其它治疗剂的递送载体，例如用于基因治疗的药物分子或核酸。 在这种情况下，聚合物本身的抗肿瘤活性可补充待递送药剂的活性。
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