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公开(公告)号：US10906938B2
公开(公告)日：2021-02-02
申请号：US16903119
申请日：2020-06-16
发明人： Hans-Georg Rammensee , Juliane Walz , Daniel Johannes Kowalewski , Stefan Stevanovic , Simon Walz
IPC分类号： C07K7/06 , C07K14/705 , A61K38/00 , C12N5/0783 , A61K35/17 , A61K39/00 , C07K16/00 , C07K16/30 , C07K7/08 , A61P35/00 , G01N33/574 , G01N33/53
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer, in particular myeloma. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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2.发明授权公开(公告)号：US10364271B2
公开(公告)日：2019-07-30
申请号：US16179677
申请日：2018-11-02
IPC分类号： A61K38/00 , C07K7/06 , C12N5/0783 , C12Q1/6886 , G01N33/574 , G16B35/00 , G16C20/60 , C07K14/74 , C07K14/47 , A61K39/00
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to several novel peptide sequences and their variants derived from HLA class I and HLA class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
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3.发明申请公开(公告)号：US20180311330A1
公开(公告)日：2018-11-01
申请号：US16032231
申请日：2018-07-11
发明人： Hans-Georg Rammensee , Stefan Stevanovic , Juliane Stickel , Daniel Johannes Kowalewski , Claudia Berlin
IPC分类号： A61K39/00 , C07K14/47 , C12Q1/6886 , G01N33/50 , A61K35/17 , C07K14/725 , C07K7/02 , C07K7/08 , C07K7/06 , C12N9/90
CPC分类号： A61K39/0011 , A61K35/17 , A61K2039/5156 , A61K2039/5158 , A61K2039/572 , C07K7/02 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/4748 , C07K14/7051 , C07K2319/70 , C12N5/0638 , C12N9/14 , C12N9/90 , C12Q1/6886 , C12Q2600/136 , C12Y306/04004 , C12Y599/01002 , G01N33/505
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to several novel peptide sequences and their variants derived from HLA class I and HLA class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
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公开(公告)号：US11103534B2
公开(公告)日：2021-08-31
申请号：US16916220
申请日：2020-06-30
发明人： Juliane Sarah Walz , Daniel Johannes Kowalewski , Markus Loeffler , Moreno Di Marco , Nico Trautwein , Annika Nelde , Stefan Stevanovic , Hans-Georg Rammensee , Sebastian Haen
IPC分类号： A61K35/17 , A61P35/00 , C07K7/06 , C07K14/74 , C07K16/28 , C07K14/725 , C12N15/115 , A61K39/00 , C12N5/0783 , C07K14/47 , G01N33/50
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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5.发明授权公开(公告)号：US10993963B2
公开(公告)日：2021-05-04
申请号：US16793721
申请日：2020-02-18
发明人： Juliane Sarah Walz , Daniel Johannes Kowalewski , Markus Loeffler , Moreno Di Marco , Nico Trautwein , Annika Nelde , Stefan Stevanovic , Hans-Georg Rammensee , Sebastian Haen
IPC分类号： A61K35/17 , A61P35/02 , A61P35/00 , C12N5/0783 , C07K14/74 , C07K16/28 , C07K14/725 , C12N15/115 , A61K39/00 , C07K14/47 , A61K38/00
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US10899794B2
公开(公告)日：2021-01-26
申请号：US16903077
申请日：2020-06-16
发明人： Hans-Georg Rammensee , Juliane Walz , Daniel Johannes Kowalewski , Stefan Stevanovic , Simon Walz
IPC分类号： C07K7/06 , C07K14/705 , A61K38/00 , C12N5/0783 , A61K35/17 , A61K39/00 , C07K16/00 , C07K16/30 , C07K7/08 , A61P35/00 , G01N33/574 , G01N33/53
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer, in particular myeloma. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US10898562B1
公开(公告)日：2021-01-26
申请号：US17039032
申请日：2020-09-30
发明人： Hans-Georg Rammensee , Stefan Stevanovic , Juliane Walz , Daniel Johannes Kowalewski , Claudia Berlin
IPC分类号： A61K39/00 , G01N33/50 , C12Q1/6886 , C07K14/47 , C12N9/90 , C12N9/14 , A61K35/17 , C07K7/02 , C07K7/08 , C07K7/06 , C07K14/725 , C12N5/0783
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to several novel peptide sequences and their variants derived from HLA class I and HLA class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
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公开(公告)号：US10525115B2
公开(公告)日：2020-01-07
申请号：US16370250
申请日：2019-03-29
发明人： Hans-Georg Rammensee , Stefan Stevanovic , Juliane Walz , Daniel Johannes Kowalewski , Claudia Berlin
IPC分类号： A61K39/00 , C07K14/47 , G01N33/50 , C12Q1/6886 , C12N9/90 , C12N9/14 , A61K35/17 , C07K7/02 , C07K7/08 , C07K7/06 , C07K14/725 , C12N5/0783
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to several novel peptide sequences and their variants derived from HLA class I and HLA class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
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9.发明申请公开(公告)号：US20190284236A1
公开(公告)日：2019-09-19
申请号：US16425804
申请日：2019-05-29
发明人： Hans-Georg Rammensee , Juliane Walz , Daniel Johannes Kowalewski , Stefan Stevanovic , Simon Walz
IPC分类号： C07K7/06 , C07K14/705 , G01N33/574 , G01N33/53 , A61K38/00 , C12N5/0783 , C07K7/08 , A61K35/17 , A61K39/00 , C07K16/00 , C07K16/30
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer, in particular myeloma. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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10.发明申请公开(公告)号：US20190077832A1
公开(公告)日：2019-03-14
申请号：US16196812
申请日：2018-11-20
发明人： Hans-Georg Rammensee , Juliane Stickel , Daniel Johannes Kowalewski , Stefan Stevanovic , Simon Walz
IPC分类号： C07K7/06 , C07K14/705 , G01N33/574 , G01N33/53 , A61K38/00
CPC分类号： C07K7/06 , A61K35/17 , A61K38/00 , A61K39/0011 , A61K2039/5158 , C07K7/08 , C07K14/705 , C07K16/00 , C07K16/30 , C12N5/0636 , C12N2800/00 , G01N33/5308 , G01N33/574
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer, in particular myeloma. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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