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1.发明申请PHARMACEUTICAL COMPOSITION COMPRISING A BIGUANIDE DERIVATIVE AS AN ACTIVE INGREDIENT FOR PREVENTING OR TREATING GLIOBLASTOMA 有权包含作为预防或治疗GLIOBLASTOMA的活性成分的BIGUANIDE衍生物的药物组合物公开(公告)号：US20160331724A1
公开(公告)日：2016-11-17
申请号：US15154788
申请日：2016-05-13
发明人： Seok Gu Kang , Ji Hyun Lee , Jong Hee Chang , Jae Ho Cheong , Jun Jeong Choi , Sung Wuk Kim , Sang Hee Yoo , Hong Woo Kim , Soon Im Lee
IPC分类号： A61K31/40 , A61K31/495
CPC分类号： A61K31/40 , A61K31/402 , A61K31/495 , A61K2300/00
摘要： The present invention provides novel uses of a biguanide derivative for preventing or treating glioblastoma. The compound of Formula 1 and its pharmaceutically acceptable salts can be used for preventing and treating glioblastoma. Further, the combined treatment of the compound of Formula 1 and temozolomide can provide superior effects compared to the administration of the compound of Formula alone or temozolomide alone.
摘要翻译： 本发明提供双胍衍生物预防或治疗胶质母细胞瘤的新用途。 式1的化合物及其药学上可接受的盐可用于预防和治疗胶质母细胞瘤。 此外，与单独给予化合物或单独使用替莫唑胺相比，式1化合物和替莫唑胺的联合治疗可以提供优异的效果。
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公开(公告)号：US10058558B2
公开(公告)日：2018-08-28
申请号：US14893433
申请日：2014-05-20
发明人： Sung Wuk Kim , Soon Im Lee , Yeon Jung Song , Min Jae Shin , Kook Hwan Oh , Kyung Don Ju , Eun Kyoung Shin , Ji Sun Lee , Hye Jin Heo , Hong Bum Lee , Ji Ae Kook , Min Jeong Kim , Hye Soun Eum
IPC分类号： A61K31/165 , A61K31/55 , A61K31/155 , C07C279/26 , A61K31/397 , A61K31/40 , A61K31/44 , A61K31/445
CPC分类号： A61K31/55 , A61K31/155 , A61K31/397 , A61K31/40 , A61K31/44 , A61K31/445 , C07C279/26
摘要： The present invention provides a novel use of N1-cyclic amine-N5-substituted biguanide derivatives for preparing a medicine for preventing or treating fibrosis. The N1-cyclic amine-N5-substituted biguanide derivatives according to the present invention are capable of effectively inhibiting fibrosis by effectively suppressing the EMT.
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3.发明授权Pharmaceutical composition comprising a biguanide derivative as an active ingredient for preventing or treating glioblastoma 有权包含双胍衍生物作为预防或治疗胶质母细胞瘤的活性成分的药物组合物公开(公告)号：US09539238B2
公开(公告)日：2017-01-10
申请号：US15154788
申请日：2016-05-13
发明人： Seok Gu Kang , Ji Hyun Lee , Jong Hee Chang , Jae Ho Cheong , Jun Jeong Choi , Sung Wuk Kim , Sang Hee Yoo , Hong Woo Kim , Soon Im Lee
IPC分类号： A01N43/52 , A61K31/40 , A61K31/495
CPC分类号： A61K31/40 , A61K31/402 , A61K31/495 , A61K2300/00
摘要： The present invention provides novel uses of a biguanide derivative for preventing or treating glioblastoma. The compound of Formula 1 and its pharmaceutically acceptable salts can be used for preventing and treating glioblastoma. Further, the combined treatment of the compound of Formula 1 and temozolomide can provide superior effects compared to the administration of the compound of Formula 1 alone or temozolomide alone.
摘要翻译： 本发明提供双胍衍生物预防或治疗胶质母细胞瘤的新用途。 式1的化合物及其药学上可接受的盐可用于预防和治疗胶质母细胞瘤。 此外，与单独给予式1化合物或单独使用替莫唑胺相比，式1化合物和替莫唑胺的联合治疗可以提供优异的效果。
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4.发明申请PHARMACEUTICAL COMPOSITION COMPRISING N1-CYCLIC AMINE-N5-SUBSTITUTED BIGUANIDE DERIVATIVES AS AN INGREDIENT FOR PREVENTING OR TREATING FIBROSIS 审中-公开包含N1循环胺-N5取代的双胍衍生物作为预防或治疗纤维化成分的药物组合物公开(公告)号：US20160101112A1
公开(公告)日：2016-04-14
申请号：US14893433
申请日：2014-05-20
发明人： Sung Wuk Kim , Soon Im Lee , Yeon Jung Song , Min Jae Shin , Kook Hwan Oh , Kyung Don Ju , Eun Kyoung Shin , Ji Sun Lee , Hye Jin Heo , Hong Bum Lee , Ji Ae Kook , Min Jeong Kim , Hye Soun Eum
IPC分类号： A61K31/55 , A61K31/44 , A61K31/397 , A61K31/445 , A61K31/40
CPC分类号： A61K31/55 , A61K31/155 , A61K31/397 , A61K31/40 , A61K31/44 , A61K31/445 , C07C279/26
摘要： The present invention provides a novel use of N1-cyclic amine-N5-substituted biguanide derivatives for preparing a medicine for preventing or treating fibrosis. The N1-cyclic amine-N5-substituted biguanide derivatives according to the present invention are capable of effectively inhibiting fibrosis by effectively suppressing the EMT.
摘要翻译： 本发明提供了N1环胺-N5取代双胍衍生物用于制备预防或治疗纤维化的药物的新用途。 根据本发明的N1环胺-N5取代双胍衍生物能够通过有效地抑制EMT而有效地抑制纤维化。
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