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    BORATE-BASED BASE GENERATOR, AND BASE-REACTIVE COMPOSITION COMPRISING SUCH BASE GENERATOR
    6.
    发明申请
    BORATE-BASED BASE GENERATOR, AND BASE-REACTIVE COMPOSITION COMPRISING SUCH BASE GENERATOR 审中-公开
    基于硼酸盐的基因发生器和包含这种基因发生器的基础反应性组合物

    公开(公告)号：US20160340374A1

    公开(公告)日：2016-11-24

    申请号：US15114048

    申请日：2015-01-22

    申请人： WAKO PURE CHEMICAL INDUSTRIES, LTD.

    发明人： Nobuhiko SAKAI ,  Kosuke YANABA

    IPC分类号： C07F9/22 ,  G03F7/004 ,  C07F5/02 ,  C07D487/04 ,  C07C279/26 ,  C07D233/50

    CPC分类号： C07F9/22 ,  C07C229/26 ,  C07C279/02 ,  C07C279/04 ,  C07C279/16 ,  C07C279/18 ,  C07C279/26 ,  C07C2601/14 ,  C07D233/50 ,  C07D487/04 ,  C07F5/027 ,  C07F9/065 ,  C07F9/5337 ,  C07F9/572 ,  C07F9/6584 ,  C07F9/65848 ,  G03F7/0045

    摘要： An object of the present invention is to provide a compound which is capable of attaining a composition having high storage stability without reacting with a base-reactive compound, even in the case of storage for a long period of time in a mixed state with the base-reactive compound, such as an epoxy-based compound, as well as capable of generating a strong base (guanidines, biguanides, phosphazenes or phosphoniums) by irradiation of light (active energy rays) or heating; a base generator comprising the compound; and a base-reactive composition comprising the base generator and the base-reactive compound.The present invention relates to the compound represented by the general formula (A); the base generator comprising the compound; and the base-reactive composition comprising the base generator and the base-reactive compound. (wherein R1 represents an alkyl group; an arylalkynyl group which may be substituted with a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group; an alkenyl group; a 2-furylethynyl group; a 2-thiophenylethynyl group; or a 2,6-dithianyl group; R2 to R4 each independently represent an alkyl group; an arylalkynyl group which may be substituted with a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group; the aryl group which may be substituted with a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group; a furanyl group; a thienyl group; or an N-alkyl-substituted pyrrolyl group; Z+ represents an ammonium cation having a guanidinium group, a biguanidium group or a phosphazenium group, or a phosphonium cation.)

    摘要翻译： （其中R1表示烷基;可被卤素原子，烷基，烷氧基或烷硫基取代的芳基炔基;烯基; 2-糠基乙炔基; 2-噻吩基乙炔基;或 2,6-二噻吩基; R 2〜R 4各自独立地表示烷基;可被卤素原子，烷基，烷氧基或烷硫基取代的芳基炔基;可被取代的芳基 具有卤素原子，烷基，烷氧基或烷硫基;呋喃基;噻吩基或N-烷基取代的吡咯基; Z +表示具有胍基的铵阳离子，双胍基或 磷腈鎓基或磷鎓阳离子）

    Omefibrates for Treating Dyslipidemia and Cardiovascular Disease
    8.
    发明申请
    Omefibrates for Treating Dyslipidemia and Cardiovascular Disease 审中-公开
    用于治疗血脂异常和心血管疾病的Omefibrates

    公开(公告)号：US20150344402A1

    公开(公告)日：2015-12-03

    申请号：US14721258

    申请日：2015-05-26

    申请人： Jiva Pharma, Inc.

    发明人： Om P. Goel

    IPC分类号： C07C69/587 ,  C07C57/03 ,  C07C279/26

    CPC分类号： C07C69/587 ,  C07C57/03 ,  C07C279/26

    摘要： The present invention relates to the fibric acid derivatives of omega-3 fatty acids and their use in treating Type2 diabetes, obesity, hypertriglyceridemia, cardiovascular diseases, metabolic syndrome, cancer, Alzheimer's disease; and their use for modulating activity of peroxisome proliferator-activated receptors (PPARs).

    摘要翻译： 本发明涉及ω-3脂肪酸的纤维酸衍生物及其在治疗2型糖尿病，肥胖症，高甘油三酯血症，心血管疾病，代谢综合征，癌症，阿尔茨海默氏病中的用途; 及其用于调节过氧化物酶体增殖物激活受体（PPAR）活性的用途。

    Metformin folate and preparation of the same
    10.
    发明授权
    Metformin folate and preparation of the same 失效
    二甲双胍叶酸及其制备方法相同

    公开(公告)号：US08329710B2

    公开(公告)日：2012-12-11

    申请号：US12515657

    申请日：2007-05-11

    申请人： Hongping Yie ,  Meg M. Sun ,  Zuolin Zhu

    发明人： Hongping Yie ,  Meg M. Sun ,  Zuolin Zhu

    IPC分类号： A61K31/519

    CPC分类号： C07D475/08 ,  C07C279/26

    摘要： This disclosure is directed to compound having the formula (A) and a method of treatment using the compound. Compared with metformin, the disclosed compound has the same clinic curative effect, such as lowering blood sugar, curing poly-cystic ovary syndrome (PCOS), losing weight and so on, without resulting in the increase of homocysteine concentration, even with a little decrease of homocysteine concentration in some cases.

    摘要翻译： 本公开涉及具有式（A）的化合物和使用该化合物的方法。 与二甲双胍相比，所公开的化合物具有降低血糖，治愈多囊卵巢综合征（PCOS），减轻体重等临床疗效，而不会导致高半胱氨酸浓度升高，甚至略有下降 的同型半胱氨酸浓度。