公开(公告)号：US20130273519A1

公开(公告)日：2013-10-17

申请号：US13669187

申请日：2012-11-05

申请人： In Chan Youn ,  Kwang Meyung Kim ,  Kui Won Choi ,  Ick Chan Kwon ,  Jun Uk Chu ,  Jong Woong Park ,  Soo Young Yoon ,  Sung Jae Choi ,  Ae Ju Lee ,  Young Mo Kang

发明人： In Chan Youn ,  Kwang Meyung Kim ,  Kui Won Choi ,  Ick Chan Kwon ,  Jun Uk Chu ,  Jong Woong Park ,  Soo Young Yoon ,  Sung Jae Choi ,  Ae Ju Lee ,  Young Mo Kang

IPC分类号： C12Q1/37 ,  C12N5/078

CPC分类号： C12Q1/37 ,  C12N5/0634 ,  G01N2333/96494 ,  G01N2800/102

摘要： The present invention relates to a composition for treating blood, a set of a diagnostic kit comprising the same to detect an autoimmune disease, and a method of monitoring an autoimmune disease using the same.An autoimmune disease such as rheumatoid arthritis can be early diagnosed, and disease progression and a treatment response can be precisely predicted, using a technique of amplifying enzyme by stimulating blood obtained from patient.

摘要翻译： 本发明涉及一种用于治疗血液的组合物，一套包含该组合物以检测自身免疫疾病的诊断试剂盒，以及使用该组合物监测自身免疫疾病的方法。 可以早期诊断自身免疫性疾病，例如类风湿性关节炎，并且可以使用通过刺激从患者获得的血液来扩增酶的技术来精确预测疾病进展和治疗反应。

公开(公告)号：US08666499B2

公开(公告)日：2014-03-04

申请号：US13166250

申请日：2011-06-22

申请人： In Chan Youn ,  Kui Won Choi ,  Jun Kyo Suh ,  Ji Yoon Kang ,  Jin Seok Kim ,  Jun Uk Chu ,  Ick Chan Kwon ,  Kwang Meyung Kim

发明人： In Chan Youn ,  Kui Won Choi ,  Jun Kyo Suh ,  Ji Yoon Kang ,  Jin Seok Kim ,  Jun Uk Chu ,  Ick Chan Kwon ,  Kwang Meyung Kim

IPC分类号： A61N1/00

CPC分类号： A61N1/36103 ,  A61N1/0551 ,  A61N1/0556 ,  A61N1/36057 ,  A61N1/36139 ,  A61N1/37288

摘要： Disclosed are a system and a method for artificial nerve networking capable of restoring a damaged nerve and allowing selective detection, analysis, transmission and stimulation of a signal from the damaged nerve. The artificial nerve networking system according to an embodiment of the present disclosure includes: a first nerve conduit connected at one end of a damaged nerve; a second nerve conduit connected at the other end of the damaged nerve; and an artificial nerve networking unit electrically connected to the first nerve conduit and the second nerve conduit and recovering the function of the damaged nerve by transmitting and receiving a signal to and from the damaged nerve.

摘要翻译： 公开了一种用于人造神经网络的系统和方法，其能够恢复受损的神经，并允许选择性地检测，分析，传输和刺激来自受损神经的信号。 根据本公开的实施例的人造神经网络系统包括：在受损神经的一端连接的第一神经导管; 在受损神经的另一端连接的第二神经管; 以及人造神经网络单元，电连接到第一神经导管和第二神经导管，并且通过向受损神经传导和接收信号来恢复受损神经的功能。

公开(公告)号：US20120253423A1

公开(公告)日：2012-10-04

申请号：US13166250

申请日：2011-06-22

申请人： In Chan Youn ,  Kui Won Choi ,  Jun-Kyo Francis Suh ,  Ji Yoon Kang ,  Jin Seok Kim ,  Jun Uk Chu ,  Ick Chan Kwon ,  Kwang Meyung Kim

发明人： In Chan Youn ,  Kui Won Choi ,  Jun-Kyo Francis Suh ,  Ji Yoon Kang ,  Jin Seok Kim ,  Jun Uk Chu ,  Ick Chan Kwon ,  Kwang Meyung Kim

IPC分类号： A61N1/00 ,  A61B17/00

CPC分类号： A61N1/36103 ,  A61N1/0551 ,  A61N1/0556 ,  A61N1/36057 ,  A61N1/36139 ,  A61N1/37288

摘要： Disclosed are a system and a method for artificial nerve networking capable of restoring a damaged nerve and allowing selective detection, analysis, transmission and stimulation of a signal from the damaged nerve. The artificial nerve networking system according to an embodiment of the present disclosure includes: a first nerve conduit connected at one end of a damaged nerve; a second nerve conduit connected at the other end of the damaged nerve; and an artificial nerve networking unit electrically connected to the first nerve conduit and the second nerve conduit and recovering the function of the damaged nerve by transmitting and receiving a signal to and from the damaged nerve.

摘要翻译： 公开了一种用于人造神经网络的系统和方法，其能够恢复受损的神经，并允许选择性地检测，分析，传输和刺激来自受损神经的信号。 根据本公开的实施例的人造神经网络系统包括：在受损神经的一端连接的第一神经导管; 在受损神经的另一端连接的第二神经管; 以及人造神经网络单元，电连接到第一神经导管和第二神经导管，并且通过向受损神经传导和接收信号来恢复损伤的神经的功能。

公开(公告)号：US20130253606A1

公开(公告)日：2013-09-26

申请号：US13676598

申请日：2012-11-14

申请人： In Chan Youn ,  Kui Won Choi ,  Jun-Kyo Francis Suh ,  Kwang Meyung Kim ,  Jun Uk Chu ,  Sung Min Han ,  Kang Il Song ,  Heui Chang Lee ,  Jong Woong Park

发明人： In Chan Youn ,  Kui Won Choi ,  Jun-Kyo Francis Suh ,  Kwang Meyung Kim ,  Jun Uk Chu ,  Sung Min Han ,  Kang Il Song ,  Heui Chang Lee ,  Jong Woong Park

IPC分类号： A61N1/36

CPC分类号： A61N1/36003 ,  A61B5/04001 ,  A61B5/4041 ,  A61B5/6877 ,  A61F2/583 ,  A61F2/72 ,  A61F2002/704 ,  A61F2002/705 ,  A61N1/0551

摘要： The present disclosure relates to peripheral nerve interface system and method for prosthetic hand control, which may measure, analyze and control efferent motor nerve signals and afferent sensory nerve signals by regenerating a peripheral nerve and control an artificial prosthetic hand by means of the measurement, analysis and control of the signals. For this, the peripheral nerve interface system according to an embodiment of the present disclosure includes: a nerve conduit connected to a terminal of a damaged peripheral nerve at a cut body portion; a prosthesis for substituting for the cut body portion; and a peripheral nerve interface unit electrically connected to the nerve conduit and the prosthesis to restore a function of the damaged peripheral nerve and control operations of the prosthesis by transmitting and receiving signals of the damaged peripheral nerve.

摘要翻译： 本公开涉及用于假肢手部控制的周围神经接口系统和方法，其可以通过再生周围神经并通过测量，分析来控制人造假手来测量，分析和控制传出的运动神经信号和传入感觉神经信号 并控制信号。 为此，根据本公开的实施方式的周围神经接口系统包括：连接到切割体部分的损伤的周围神经的末端的神经导管; 用于代替切割体部分的假体; 以及外周神经接口单元，其电连接到神经导管和假体，以通过发送和接收损伤的周围神经的信号来恢复损伤的周围神经的功能和假体的控制操作。

公开(公告)号：US08676334B2

公开(公告)日：2014-03-18

申请号：US13676598

申请日：2012-11-14

申请人： In Chan Youn ,  Kui Won Choi ,  Jun-Kyo Francis Suh ,  Kwang Meyung Kim ,  Jun Uk Chu ,  Sung Min Han ,  Kang Il Song ,  Heui Chang Lee ,  Jong Woong Park

发明人： In Chan Youn ,  Kui Won Choi ,  Jun-Kyo Francis Suh ,  Kwang Meyung Kim ,  Jun Uk Chu ,  Sung Min Han ,  Kang Il Song ,  Heui Chang Lee ,  Jong Woong Park

IPC分类号： A61N1/00

CPC分类号： A61N1/36003 ,  A61B5/04001 ,  A61B5/4041 ,  A61B5/6877 ,  A61F2/583 ,  A61F2/72 ,  A61F2002/704 ,  A61F2002/705 ,  A61N1/0551

摘要： The present disclosure relates to peripheral nerve interface system and method for prosthetic hand control, which may measure, analyze and control efferent motor nerve signals and afferent sensory nerve signals by regenerating a peripheral nerve and control an artificial prosthetic hand by means of the measurement, analysis and control of the signals. For this, the peripheral nerve interface system according to an embodiment of the present disclosure includes: a nerve conduit connected to a terminal of a damaged peripheral nerve at a cut body portion; a prosthesis for substituting for the cut body portion; and a peripheral nerve interface unit electrically connected to the nerve conduit and the prosthesis to restore a function of the damaged peripheral nerve and control operations of the prosthesis by transmitting and receiving signals of the damaged peripheral nerve.

摘要翻译： 本公开涉及用于假肢手部控制的周围神经接口系统和方法，其可以通过再生周围神经并通过测量，分析来控制人造假手来测量，分析和控制传出的运动神经信号和传入感觉神经信号 并控制信号。 为此，根据本公开的实施方式的周围神经接口系统包括：连接到切割体部分的损伤的周围神经的末端的神经导管; 用于代替切割体部分的假体; 以及外周神经接口单元，其电连接到神经导管和假体，以通过发送和接收损伤的周围神经的信号来恢复损伤的周围神经的功能和假体的控制操作。

公开(公告)号：US08530047B2

公开(公告)日：2013-09-10

申请号：US13142876

申请日：2010-03-02

申请人： KwangMeyung Kim ,  Ick Chan Kwon ,  Kui Won Choi ,  Seung Young Lee ,  In Chan Youn ,  Myung Sook Huh ,  So Jin Lee

发明人： KwangMeyung Kim ,  Ick Chan Kwon ,  Kui Won Choi ,  Seung Young Lee ,  In Chan Youn ,  Myung Sook Huh ,  So Jin Lee

IPC分类号： B32B5/16

CPC分类号： C12N15/111 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/51 ,  C12N2320/32 ,  C12N2320/51

摘要： The oligonucleotide polymerization method of the present invention is advantageous in that an oligonucleotide with a small molecular weight can be easily polymerized into high-molecular weight oligonucleotides. Further, the high-molecular oligonucleotide prepared by the method of the present invention can bind to hydrophilic high-molecular materials or inorganic materials, and then can be stably delivered to a living body. Therefore, the high-molecular oligonucleotide prepared by the method of the present invention can be widely used for treating various diseases.

摘要翻译： 本发明的寡聚体聚合方法的优点在于，可以容易地将分子量小的寡核苷酸聚合成高分子量寡核苷酸。 此外，通过本发明的方法制备的高分子量寡核苷酸可以结合亲水性高分子材料或无机材料，然后可以稳定地递送到生物体。 因此，通过本发明的方法制备的高分子寡核苷酸可广泛用于治疗各种疾病。

公开(公告)号：US08513402B2

公开(公告)日：2013-08-20

申请号：US13245180

申请日：2011-09-26

申请人： Kwangmeyung Kim ,  Ick Chan Kwon ,  Kuiwon Choi ,  In Chan Youn ,  MyungSook Huh ,  Sojin Lee

发明人： Kwangmeyung Kim ,  Ick Chan Kwon ,  Kuiwon Choi ,  In Chan Youn ,  MyungSook Huh ,  Sojin Lee

IPC分类号： C07H21/04

CPC分类号： C12N15/111 ,  A61K47/643 ,  C12N2320/32

摘要： Disclosed are a human serum albumin-siRNA carrier system having siRNA bound to human serum albumin and a user thereof, and especially, human serum albumin-siRNA carrier system, which has a biodegradable covalent bond between human serum albumin polymer and siRNA and is stable in a living body, and a user thereof.The human serum albumin-siRNA carrier system having the biodegradable covalent bond between the human serum albumin and the siRNA exhibits high siRNA delivery efficiency to a target site in the living body. Therefore, the human serum albumin-siRNA carrier system may allow siRNA for therapy to be efficiently delivered to a target site such as cancer tissues in the living body even by being administrated in a relatively low concentration, which may result in a wide use for therapies of various diseases.

摘要翻译： 公开了具有与人血清白蛋白结合的siRNA及其使用者的人血清白蛋白-siRNA载体体系，特别是人血清白蛋白-siRNA载体体系，其在人血清白蛋白聚合物和siRNA之间具有可生物降解的共价键，并且在 生物体及其使用者。 在人体血清白蛋白和siRNA之间具有可生物降解的共价键的人血清白蛋白-siRNA载体体系对生物体中的靶位点显示出高的siRNA递送效率。 因此，人体血清白蛋白-siRNA载体体系可以使siRNA用于治疗有效地递送到目标部位如生物体中的癌组织，甚至通过以相对低的浓度施用，这可能导致广泛用于治疗 的各种疾病。

公开(公告)号：US20110274930A1

公开(公告)日：2011-11-10

申请号：US13142876

申请日：2010-03-02

申请人： KwangMeyung Kim ,  Iek Chan Kwon ,  Kui Won Choi ,  Seung Young Lee ,  In Chan Youn ,  Myung Sook Huh ,  So Jin Lee

发明人： KwangMeyung Kim ,  Iek Chan Kwon ,  Kui Won Choi ,  Seung Young Lee ,  In Chan Youn ,  Myung Sook Huh ,  So Jin Lee

IPC分类号： C07H21/02 ,  B32B5/16 ,  C08G73/04

CPC分类号： C12N15/111 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/51 ,  C12N2320/32 ,  C12N2320/51

摘要： The present invention relates to a high-molecular weight oligonucleotides polymerization method which increases in vivo stability, and to the use of a high-molecular weight oligonucleotides prepared by the polymerization method.The oligonucleotide polymerization method of the present invention is advantageous in that an oligonucleotide with a small molecular weight can be easily polymerized into high-molecular weight oligonucleotides. Further, the high-molecular oligonucleotide prepared by the method of the present invention can bind to hydrophilic high-molecular materials or inorganic materials, and then can be stably delivered to a living body. Therefore, the high-molecular oligonucleotide prepared by the method of the present invention can be widely used for treating various diseases.

摘要翻译： 本发明涉及增加体内稳定性的高分子量寡核苷酸聚合方法以及通过聚合方法制备的高分子量寡核苷酸的用途。 本发明的寡聚体聚合方法的优点在于，可以容易地将分子量小的寡核苷酸聚合成高分子量寡核苷酸。 此外，通过本发明的方法制备的高分子量寡核苷酸可以结合亲水性高分子材料或无机材料，然后可以稳定地递送到生物体。 因此，通过本发明的方法制备的高分子寡核苷酸可广泛用于治疗各种疾病。