公开(公告)号：US08666499B2

公开(公告)日：2014-03-04

申请号：US13166250

申请日：2011-06-22

申请人： In Chan Youn ,  Kui Won Choi ,  Jun Kyo Suh ,  Ji Yoon Kang ,  Jin Seok Kim ,  Jun Uk Chu ,  Ick Chan Kwon ,  Kwang Meyung Kim

发明人： In Chan Youn ,  Kui Won Choi ,  Jun Kyo Suh ,  Ji Yoon Kang ,  Jin Seok Kim ,  Jun Uk Chu ,  Ick Chan Kwon ,  Kwang Meyung Kim

IPC分类号： A61N1/00

CPC分类号： A61N1/36103 ,  A61N1/0551 ,  A61N1/0556 ,  A61N1/36057 ,  A61N1/36139 ,  A61N1/37288

摘要： Disclosed are a system and a method for artificial nerve networking capable of restoring a damaged nerve and allowing selective detection, analysis, transmission and stimulation of a signal from the damaged nerve. The artificial nerve networking system according to an embodiment of the present disclosure includes: a first nerve conduit connected at one end of a damaged nerve; a second nerve conduit connected at the other end of the damaged nerve; and an artificial nerve networking unit electrically connected to the first nerve conduit and the second nerve conduit and recovering the function of the damaged nerve by transmitting and receiving a signal to and from the damaged nerve.

摘要翻译： 公开了一种用于人造神经网络的系统和方法，其能够恢复受损的神经，并允许选择性地检测，分析，传输和刺激来自受损神经的信号。 根据本公开的实施例的人造神经网络系统包括：在受损神经的一端连接的第一神经导管; 在受损神经的另一端连接的第二神经管; 以及人造神经网络单元，电连接到第一神经导管和第二神经导管，并且通过向受损神经传导和接收信号来恢复受损神经的功能。

公开(公告)号：US20120253423A1

公开(公告)日：2012-10-04

申请号：US13166250

申请日：2011-06-22

申请人： In Chan Youn ,  Kui Won Choi ,  Jun-Kyo Francis Suh ,  Ji Yoon Kang ,  Jin Seok Kim ,  Jun Uk Chu ,  Ick Chan Kwon ,  Kwang Meyung Kim

发明人： In Chan Youn ,  Kui Won Choi ,  Jun-Kyo Francis Suh ,  Ji Yoon Kang ,  Jin Seok Kim ,  Jun Uk Chu ,  Ick Chan Kwon ,  Kwang Meyung Kim

IPC分类号： A61N1/00 ,  A61B17/00

CPC分类号： A61N1/36103 ,  A61N1/0551 ,  A61N1/0556 ,  A61N1/36057 ,  A61N1/36139 ,  A61N1/37288

摘要： Disclosed are a system and a method for artificial nerve networking capable of restoring a damaged nerve and allowing selective detection, analysis, transmission and stimulation of a signal from the damaged nerve. The artificial nerve networking system according to an embodiment of the present disclosure includes: a first nerve conduit connected at one end of a damaged nerve; a second nerve conduit connected at the other end of the damaged nerve; and an artificial nerve networking unit electrically connected to the first nerve conduit and the second nerve conduit and recovering the function of the damaged nerve by transmitting and receiving a signal to and from the damaged nerve.

摘要翻译： 公开了一种用于人造神经网络的系统和方法，其能够恢复受损的神经，并允许选择性地检测，分析，传输和刺激来自受损神经的信号。 根据本公开的实施例的人造神经网络系统包括：在受损神经的一端连接的第一神经导管; 在受损神经的另一端连接的第二神经管; 以及人造神经网络单元，电连接到第一神经导管和第二神经导管，并且通过向受损神经传导和接收信号来恢复损伤的神经的功能。

公开(公告)号：US20130273519A1

公开(公告)日：2013-10-17

申请号：US13669187

申请日：2012-11-05

申请人： In Chan Youn ,  Kwang Meyung Kim ,  Kui Won Choi ,  Ick Chan Kwon ,  Jun Uk Chu ,  Jong Woong Park ,  Soo Young Yoon ,  Sung Jae Choi ,  Ae Ju Lee ,  Young Mo Kang

发明人： In Chan Youn ,  Kwang Meyung Kim ,  Kui Won Choi ,  Ick Chan Kwon ,  Jun Uk Chu ,  Jong Woong Park ,  Soo Young Yoon ,  Sung Jae Choi ,  Ae Ju Lee ,  Young Mo Kang

IPC分类号： C12Q1/37 ,  C12N5/078

CPC分类号： C12Q1/37 ,  C12N5/0634 ,  G01N2333/96494 ,  G01N2800/102

摘要： The present invention relates to a composition for treating blood, a set of a diagnostic kit comprising the same to detect an autoimmune disease, and a method of monitoring an autoimmune disease using the same.An autoimmune disease such as rheumatoid arthritis can be early diagnosed, and disease progression and a treatment response can be precisely predicted, using a technique of amplifying enzyme by stimulating blood obtained from patient.

摘要翻译： 本发明涉及一种用于治疗血液的组合物，一套包含该组合物以检测自身免疫疾病的诊断试剂盒，以及使用该组合物监测自身免疫疾病的方法。 可以早期诊断自身免疫性疾病，例如类风湿性关节炎，并且可以使用通过刺激从患者获得的血液来扩增酶的技术来精确预测疾病进展和治疗反应。

公开(公告)号：US08676334B2

公开(公告)日：2014-03-18

申请号：US13676598

申请日：2012-11-14

申请人： In Chan Youn ,  Kui Won Choi ,  Jun-Kyo Francis Suh ,  Kwang Meyung Kim ,  Jun Uk Chu ,  Sung Min Han ,  Kang Il Song ,  Heui Chang Lee ,  Jong Woong Park

发明人： In Chan Youn ,  Kui Won Choi ,  Jun-Kyo Francis Suh ,  Kwang Meyung Kim ,  Jun Uk Chu ,  Sung Min Han ,  Kang Il Song ,  Heui Chang Lee ,  Jong Woong Park

IPC分类号： A61N1/00

CPC分类号： A61N1/36003 ,  A61B5/04001 ,  A61B5/4041 ,  A61B5/6877 ,  A61F2/583 ,  A61F2/72 ,  A61F2002/704 ,  A61F2002/705 ,  A61N1/0551

摘要： The present disclosure relates to peripheral nerve interface system and method for prosthetic hand control, which may measure, analyze and control efferent motor nerve signals and afferent sensory nerve signals by regenerating a peripheral nerve and control an artificial prosthetic hand by means of the measurement, analysis and control of the signals. For this, the peripheral nerve interface system according to an embodiment of the present disclosure includes: a nerve conduit connected to a terminal of a damaged peripheral nerve at a cut body portion; a prosthesis for substituting for the cut body portion; and a peripheral nerve interface unit electrically connected to the nerve conduit and the prosthesis to restore a function of the damaged peripheral nerve and control operations of the prosthesis by transmitting and receiving signals of the damaged peripheral nerve.

摘要翻译： 本公开涉及用于假肢手部控制的周围神经接口系统和方法，其可以通过再生周围神经并通过测量，分析来控制人造假手来测量，分析和控制传出的运动神经信号和传入感觉神经信号 并控制信号。 为此，根据本公开的实施方式的周围神经接口系统包括：连接到切割体部分的损伤的周围神经的末端的神经导管; 用于代替切割体部分的假体; 以及外周神经接口单元，其电连接到神经导管和假体，以通过发送和接收损伤的周围神经的信号来恢复损伤的周围神经的功能和假体的控制操作。

公开(公告)号：US20130253606A1

公开(公告)日：2013-09-26

申请号：US13676598

申请日：2012-11-14

申请人： In Chan Youn ,  Kui Won Choi ,  Jun-Kyo Francis Suh ,  Kwang Meyung Kim ,  Jun Uk Chu ,  Sung Min Han ,  Kang Il Song ,  Heui Chang Lee ,  Jong Woong Park

发明人： In Chan Youn ,  Kui Won Choi ,  Jun-Kyo Francis Suh ,  Kwang Meyung Kim ,  Jun Uk Chu ,  Sung Min Han ,  Kang Il Song ,  Heui Chang Lee ,  Jong Woong Park

IPC分类号： A61N1/36

CPC分类号： A61N1/36003 ,  A61B5/04001 ,  A61B5/4041 ,  A61B5/6877 ,  A61F2/583 ,  A61F2/72 ,  A61F2002/704 ,  A61F2002/705 ,  A61N1/0551

摘要： The present disclosure relates to peripheral nerve interface system and method for prosthetic hand control, which may measure, analyze and control efferent motor nerve signals and afferent sensory nerve signals by regenerating a peripheral nerve and control an artificial prosthetic hand by means of the measurement, analysis and control of the signals. For this, the peripheral nerve interface system according to an embodiment of the present disclosure includes: a nerve conduit connected to a terminal of a damaged peripheral nerve at a cut body portion; a prosthesis for substituting for the cut body portion; and a peripheral nerve interface unit electrically connected to the nerve conduit and the prosthesis to restore a function of the damaged peripheral nerve and control operations of the prosthesis by transmitting and receiving signals of the damaged peripheral nerve.

摘要翻译： 本公开涉及用于假肢手部控制的周围神经接口系统和方法，其可以通过再生周围神经并通过测量，分析来控制人造假手来测量，分析和控制传出的运动神经信号和传入感觉神经信号 并控制信号。 为此，根据本公开的实施方式的周围神经接口系统包括：连接到切割体部分的损伤的周围神经的末端的神经导管; 用于代替切割体部分的假体; 以及外周神经接口单元，其电连接到神经导管和假体，以通过发送和接收损伤的周围神经的信号来恢复损伤的周围神经的功能和假体的控制操作。

公开(公告)号：US09061068B2

公开(公告)日：2015-06-23

申请号：US12905212

申请日：2010-10-15

申请人： Kwang Meyung Kim ,  Ick Chan Kwon ,  Kuiwon Choi ,  Myung Sook Huh ,  Seung Young Lee ,  So Jin Lee

发明人： Kwang Meyung Kim ,  Ick Chan Kwon ,  Kuiwon Choi ,  Myung Sook Huh ,  Seung Young Lee ,  So Jin Lee

IPC分类号： C07H21/02 ,  A61K47/48 ,  C12N15/11 ,  C12N15/87

CPC分类号： A61K47/4823 ,  A61K47/61 ,  A61K47/6939 ,  C12N15/111 ,  C12N15/87 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2320/32

摘要： Disclosed is a polymer-siRNA delivery carrier in which a siRNA is combined with a polymer and the use thereof. More specifically, there is disclosed a stable in vivo polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time and the use thereof.The polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time has a high siRNA deliver efficiency to a target portion in vivo. Hence, according to the polymer-siRNA binder, the siRNA for treatment can be effectively delivered to a target portion such as in vivo cancer tissue, and the like even with administration of a relatively low concentration, and thus widely used for the treatment of various kinds of diseases.

摘要翻译： 公开了将siRNA与聚合物组合的聚合物-siRNA递送载体及其用途。 更具体地，公开了一种稳定的体内聚合物-siRNA递送载体，其中通过使用电荷相互作用和可生物降解的共价键在同一时间将聚合物和siRNA组合起来，以及其用途。 通过使用电荷相互作用和可生物降解的共价键合将聚合物和siRNA组合的聚合物-siRNA递送载体在体内对目标部分具有高的siRNA递送效率。 因此，根据聚合物-siRNA粘合剂，即使施用相对低的浓度，也可以将治疗用siRNA有效地输送到诸如体内癌组织等目标部位，广泛用于各种治疗 各种疾病