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公开(公告)号：US20230024173A1
公开(公告)日：2023-01-26
申请号：US17816271
申请日：2022-07-29
申请人： Incyte Corporation
发明人： Qinda Ye , Jingwei Li , Ken Mukai , Brandon Smith , Liangxing Wu , Wenqing Yao , Min Ye , Yingnan Chen , Margaret Favata , Yvonne Lo
IPC分类号： C07D401/14 , A61P35/00 , C07D405/14 , C07D413/14 , C07D471/08 , C07D471/10 , C07D498/08
摘要： The present application provides imidazolyl pyrimidinylamine inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.
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公开(公告)号：US11406624B2
公开(公告)日：2022-08-09
申请号：US16518366
申请日：2019-07-22
申请人： Incyte Corporation
发明人： Alexander Sokolsky , Oleg Vechorkin , Kai Liu , Jun Pan , Wenqing Yao , Qinda Ye
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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公开(公告)号：US20220227752A1
公开(公告)日：2022-07-21
申请号：US17558824
申请日：2021-12-22
申请人： Incyte Corporation
发明人： Kai Liu , Jun Pan , Alexander Sokolsky , Oleg Vechorkin , Hai Fen Ye , Qinda Ye , Wenqing Yao
IPC分类号： C07D471/04 , C07D519/00
摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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公开(公告)号：US20210094934A1
公开(公告)日：2021-04-01
申请号：US17015797
申请日：2020-09-09
申请人： Incyte Corporation
发明人： Oleg Vechorkin , Jun Pan , Alexander Sokolsky , Evan Styduhar , Qinda Ye , Wenqing Yao
IPC分类号： C07D403/14 , C07D239/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D487/04 , C07D487/08
摘要： Disclosed are compounds of Formula (I′) methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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公开(公告)号：US20200347067A1
公开(公告)日：2020-11-05
申请号：US16863770
申请日：2020-04-30
申请人： Incyte Corporation
发明人： Qinda Ye , Neil Lajkiewicz , Ken Mukai , Liangxing Wu , Wenqing Yao
IPC分类号： C07D487/04 , A61P35/00 , C07D491/147
摘要： The present application provides tricyclic amine compounds, which are inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.
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公开(公告)号：US20190315717A1
公开(公告)日：2019-10-17
申请号：US16382482
申请日：2019-04-12
申请人： Incyte Corporation
发明人： Joshua Hummel , Minh Nguyen , Alexander Sokolsky , Oleg Vechorkin , Qinda Ye , Wenqing Yao
IPC分类号： C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , A61P35/00
摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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公开(公告)号：US11891388B2
公开(公告)日：2024-02-06
申请号：US17558824
申请日：2021-12-22
申请人： Incyte Corporation
发明人： Kai Liu , Jun Pan , Alexander Sokolsky , Oleg Vechorkin , Hai Fen Ye , Qinda Ye , Wenqing Yao
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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公开(公告)号：US11866426B2
公开(公告)日：2024-01-09
申请号：US17098880
申请日：2020-11-16
申请人： Incyte Corporation
发明人： Joshua Hummel , Oleg Vechorkin , Alexander Sokolsky , Qinda Ye , Kai Liu , Wenqing Yao
IPC分类号： C07D417/14 , A61P35/00 , C07D487/08 , C07D498/08
CPC分类号： C07D417/14 , A61P35/00 , C07D487/08 , C07D498/08
摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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公开(公告)号：US11242343B2
公开(公告)日：2022-02-08
申请号：US16786169
申请日：2020-02-10
申请人： Incyte Corporation
发明人： Kai Liu , Jun Pan , Alexander Sokolsky , Oleg Vechorkin , Hai Fen Ye , Qinda Ye , Wenqing Yao
IPC分类号： C07D471/04 , C07D519/00
摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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公开(公告)号：US20200048241A1
公开(公告)日：2020-02-13
申请号：US16534039
申请日：2019-08-07
申请人： Incyte Corporation
发明人： Joshua Hummel , Oleg Vechorkin , Alexander Sokolsky , Qinda Ye , Kai Liu , Wenqing Yao
IPC分类号： C07D417/14 , C07D498/08 , C07D487/08 , A61P35/00
摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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