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公开(公告)号：US11084822B2
公开(公告)日：2021-08-10
申请号：US16448815
申请日：2019-06-21
申请人： Incyte Corporation
发明人： Lei Qiao , Lingkai Weng , David Meloni , Zhongjiang Jia , Jianji Wang , Jiacheng Zhou
IPC分类号： C07D487/04
摘要： The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo [3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3Kδ), as well as a salt form and intermediates related thereto.
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公开(公告)号：US12024522B2
公开(公告)日：2024-07-02
申请号：US17365888
申请日：2021-07-01
申请人： Incyte Corporation
发明人： Lei Qiao , Lingkai Weng , Chongsheng Eric Shi , David Meloni , Qiyan Lin , Michael Xia , Vaqar Sharief , William Frietze , Zhongjiang Jia , Yongchun Pan , Pingli Liu , Tai-Yuen Yue , Jiacheng Zhou , Jianji Wang
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07B2200/13
摘要： The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3Kδ), as well as a salt form and intermediates related thereto.
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公开(公告)号：US20190308979A1
公开(公告)日：2019-10-10
申请号：US16448815
申请日：2019-06-21
申请人： Incyte Corporation
发明人： Lei Qiao , Lingkai Weng , David Meloni , Zhongjiang Jia , Jianji Wang , Jiacheng Zhou
IPC分类号： C07D487/04
摘要： The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo [3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3Kδ), as well as a salt form and intermediates related thereto.
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公开(公告)号：US12071439B2
公开(公告)日：2024-08-27
申请号：US17861597
申请日：2022-07-11
申请人： Incyte Corporation
发明人： Jiacheng Zhou , Shili Chen , Zhongjiang Jia , Pingli Liu , David Meloni , Yongchun Pan , Naijing Su , Michael Xia
IPC分类号： C07D487/04 , C07D205/04
CPC分类号： C07D487/04 , C07D205/04
摘要： The present disclosure is related to processes for preparing baricitinib, salts thereof, and related synthetic intermediate compounds and salts thereof.
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公开(公告)号：US20230059389A1
公开(公告)日：2023-02-23
申请号：US17861597
申请日：2022-07-11
申请人： Incyte Corporation
发明人： Jiacheng Zhou , Shili Chen , Zhongjiang Jia , Pingli Liu , David Meloni , Yongchun Pan , Naijing Su , Michael Xia
IPC分类号： C07D487/04 , C07D205/04
摘要： The present disclosure is related to processes for preparing baricitinib, salts thereof, and related synthetic intermediate compounds and salts thereof.
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公开(公告)号：US10336759B2
公开(公告)日：2019-07-02
申请号：US15054474
申请日：2016-02-26
申请人： Incyte Corporation
发明人： Lei Qiao , Lingkai Weng , David Meloni , Zhongjiang Jia , Jianji Wang , Jiacheng Zhou
IPC分类号： C07D487/04
摘要： The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3Kδ), as well as a salt form and intermediates related thereto.
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公开(公告)号：US20230399331A1
公开(公告)日：2023-12-14
申请号：US18209674
申请日：2023-06-14
申请人： Incyte Corporation
发明人： Zhongjiang Jia , Weiguo Liu , Pingli Liu , David Meloni , Yongchun Pan , Jiacheng Zhou , Travis Houston
IPC分类号： C07D487/04 , A61K9/06 , A61K47/10 , A61K47/14 , A61K47/36 , A61K47/06 , A61K47/44 , A61K47/32 , A61K47/18 , A61K47/26 , A61K9/107 , A61K9/20
CPC分类号： C07D487/04 , A61K9/06 , A61K47/10 , A61K47/14 , A61K47/36 , A61K47/06 , A61K47/44 , A61K47/32 , A61K47/183 , A61K47/26 , A61K9/107 , A61K9/2054 , A61K9/2018 , A61K9/2009 , A61K9/2013 , C07B2200/13
摘要： The present disclosure is related to solid forms of ruxolitinib di-hydrate and ruxolitinib free base, process of preparing the same, and compositions comprising the same.
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公开(公告)号：US20220024934A1
公开(公告)日：2022-01-27
申请号：US17365888
申请日：2021-07-01
申请人： Incyte Corporation
发明人： Lei Qiao , Lingkai Weng , Chongsheng Eric Shi , David Meloni , Qiyan Lin , Michael Xia , Vaqar Sharief , William Frietze , Zhongjiang Jia , Yongchun Pan , Pingli Liu , Tai-Yuen Yue , Jiacheng Zhou
IPC分类号： C07D487/04
摘要： The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3Kδ), as well as a salt form and intermediates related thereto.
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公开(公告)号：US20160257689A1
公开(公告)日：2016-09-08
申请号：US15054474
申请日：2016-02-26
申请人： Incyte Corporation
发明人： Lei Qiao , Lingkai Weng , ChongShen Eric Shi , David Meloni , Qiyan Lin , Michael Xia , Vaqar Sharief , William Frietze , Zhongjiang Jia , Yongchun Pan , Pingli Liu , Tai-Yuen Yue , Jiacheng Zhou
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07B2200/13
摘要： The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3Kδ), as well as a salt form and intermediates related thereto.
摘要翻译： 本申请提供了制备（R）-4-（3 - （（S）-1-（4-氨基-3-甲基-1H-吡唑并[3,4-d]嘧啶-1-基）乙基） -5-氯-2-乙氧基-6-氟苯基）吡咯烷-2-酮，其可用作抑制剂磷酸肌醇3-激酶-δ（PI3Kδ），以及与其相关的盐形式和中间体。
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公开(公告)号：US20210253584A1
公开(公告)日：2021-08-19
申请号：US17176914
申请日：2021-02-16
发明人： Jiacheng Zhou , Pingli Liu , Qiyan Lin , Brian W. Metcalf , David Meloni , Yongchun Pan , Michael Xia , Mei Li , Tai-Yuen Yue , James D. Rodgers , Haisheng Wang
IPC分类号： C07D487/04 , C07F7/18 , C07F7/10 , C07F5/02 , C07F7/08
摘要： The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
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