公开(公告)号：US20210253584A1

公开(公告)日：2021-08-19

申请号：US17176914

申请日：2021-02-16

申请人： Incyte Holdings Corporation ,  Incyte Corporation

发明人： Jiacheng Zhou ,  Pingli Liu ,  Qiyan Lin ,  Brian W. Metcalf ,  David Meloni ,  Yongchun Pan ,  Michael Xia ,  Mei Li ,  Tai-Yuen Yue ,  James D. Rodgers ,  Haisheng Wang

IPC分类号： C07D487/04 ,  C07F7/18 ,  C07F7/10 ,  C07F5/02 ,  C07F7/08

摘要： The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.

公开(公告)号：US09908888B2

公开(公告)日：2018-03-06

申请号：US15016918

申请日：2016-02-05

申请人： Incyte Holdings Corporation ,  Incyte Corporation

发明人： Jiacheng Zhou ,  Pingli Liu ,  Qiyan Lin ,  Brian W. Metcalf ,  David Meloni ,  Yongchun Pan ,  Michael Xia ,  Mei Li ,  Tai-Yuen Yue ,  James D. Rodgers ,  Haisheng Wang

IPC分类号： C07D487/04 ,  C07D231/10 ,  C07F7/18 ,  C07F7/10 ,  C07F5/02 ,  C07F7/08

CPC分类号： C07D487/04 ,  C07F5/025 ,  C07F7/083 ,  C07F7/10 ,  C07F7/1892 ,  Y02P20/55

摘要： The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.

公开(公告)号：US09290506B2

公开(公告)日：2016-03-22

申请号：US14593688

申请日：2015-01-09

申请人： Incyte Corporation ,  Incyte Holdings Corporation

发明人： Jiacheng Zhou ,  David Meloni ,  Yongchun Pan ,  Mei Li ,  Pingli Liu ,  Brian W. Metcalf ,  Tai-Yuen Yue

IPC分类号： C07D487/00 ,  C07D487/04 ,  C07F7/18 ,  C07F7/10

CPC分类号： C07D487/04 ,  C07F5/025 ,  C07F7/083 ,  C07F7/10 ,  C07F7/1892 ,  Y02P20/55

摘要： The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.

公开(公告)号：US11084822B2

公开(公告)日：2021-08-10

申请号：US16448815

申请日：2019-06-21

申请人： Incyte Corporation

发明人： Lei Qiao ,  Lingkai Weng ,  David Meloni ,  Zhongjiang Jia ,  Jianji Wang ,  Jiacheng Zhou

IPC分类号： C07D487/04

摘要： The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo [3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3Kδ), as well as a salt form and intermediates related thereto.

公开(公告)号：US12024522B2

公开(公告)日：2024-07-02

申请号：US17365888

申请日：2021-07-01

申请人： Incyte Corporation

发明人： Lei Qiao ,  Lingkai Weng ,  Chongsheng Eric Shi ,  David Meloni ,  Qiyan Lin ,  Michael Xia ,  Vaqar Sharief ,  William Frietze ,  Zhongjiang Jia ,  Yongchun Pan ,  Pingli Liu ,  Tai-Yuen Yue ,  Jiacheng Zhou ,  Jianji Wang

IPC分类号： C07D487/04

CPC分类号： C07D487/04 ,  C07B2200/13

摘要： The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3Kδ), as well as a salt form and intermediates related thereto.

公开(公告)号：US20190308979A1

公开(公告)日：2019-10-10

申请号：US16448815

申请日：2019-06-21

申请人： Incyte Corporation

发明人： Lei Qiao ,  Lingkai Weng ,  David Meloni ,  Zhongjiang Jia ,  Jianji Wang ,  Jiacheng Zhou

IPC分类号： C07D487/04

摘要： The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo [3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3Kδ), as well as a salt form and intermediates related thereto.

公开(公告)号：US12071439B2

公开(公告)日：2024-08-27

申请号：US17861597

申请日：2022-07-11

申请人： Incyte Corporation

发明人： Jiacheng Zhou ,  Shili Chen ,  Zhongjiang Jia ,  Pingli Liu ,  David Meloni ,  Yongchun Pan ,  Naijing Su ,  Michael Xia

IPC分类号： C07D487/04 ,  C07D205/04

CPC分类号： C07D487/04 ,  C07D205/04

摘要： The present disclosure is related to processes for preparing baricitinib, salts thereof, and related synthetic intermediate compounds and salts thereof.

公开(公告)号：US20230059389A1

公开(公告)日：2023-02-23

申请号：US17861597

申请日：2022-07-11

申请人： Incyte Corporation

发明人： Jiacheng Zhou ,  Shili Chen ,  Zhongjiang Jia ,  Pingli Liu ,  David Meloni ,  Yongchun Pan ,  Naijing Su ,  Michael Xia

IPC分类号： C07D487/04 ,  C07D205/04

摘要： The present disclosure is related to processes for preparing baricitinib, salts thereof, and related synthetic intermediate compounds and salts thereof.

公开(公告)号：US10336759B2

公开(公告)日：2019-07-02

申请号：US15054474

申请日：2016-02-26

申请人： Incyte Corporation

发明人： Lei Qiao ,  Lingkai Weng ,  David Meloni ,  Zhongjiang Jia ,  Jianji Wang ,  Jiacheng Zhou

IPC分类号： C07D487/04

摘要： The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3Kδ), as well as a salt form and intermediates related thereto.

公开(公告)号：US20230399331A1

公开(公告)日：2023-12-14

申请号：US18209674

申请日：2023-06-14

申请人： Incyte Corporation

发明人： Zhongjiang Jia ,  Weiguo Liu ,  Pingli Liu ,  David Meloni ,  Yongchun Pan ,  Jiacheng Zhou ,  Travis Houston

IPC分类号： C07D487/04 ,  A61K9/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/36 ,  A61K47/06 ,  A61K47/44 ,  A61K47/32 ,  A61K47/18 ,  A61K47/26 ,  A61K9/107 ,  A61K9/20

CPC分类号： C07D487/04 ,  A61K9/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/36 ,  A61K47/06 ,  A61K47/44 ,  A61K47/32 ,  A61K47/183 ,  A61K47/26 ,  A61K9/107 ,  A61K9/2054 ,  A61K9/2018 ,  A61K9/2009 ,  A61K9/2013 ,  C07B2200/13

摘要： The present disclosure is related to solid forms of ruxolitinib di-hydrate and ruxolitinib free base, process of preparing the same, and compositions comprising the same.