公开(公告)号：US20240150354A1

公开(公告)日：2024-05-09

申请号：US18237535

申请日：2023-08-24

申请人： Incyte Corporation

发明人： Yanran Ai ,  Onur Atasoylu ,  Yu Bai ,  Joseph Barbosa ,  David M. Burns ,  Daniel Levy ,  Brent Douty ,  Hao Feng ,  Leah C. Konkol ,  Cheng-Tsung Lai ,  Xun Liu ,  Song Mei ,  Jun Pan ,  Haisheng Wang ,  Liangxing Wu ,  Wenqing Yao ,  Eddy W. Yue

IPC分类号： C07D471/14 ,  C07D519/00

CPC分类号： C07D471/14 ,  C07D519/00 ,  C07B2200/05

摘要： The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

公开(公告)号：US20240150326A1

公开(公告)日：2024-05-09

申请号：US18212444

申请日：2023-06-21

申请人： Incyte Corporation

发明人： Oleg Vechorkin ,  Jun Pan ,  Alexander Sokolsky ,  Evan Styduhar ,  Qinda Ye ,  Wenqing Yao

IPC分类号： C07D403/14 ,  C07D239/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D487/04 ,  C07D487/08

CPC分类号： C07D403/14 ,  C07D239/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D487/04 ,  C07D487/08

摘要： Disclosed are compounds of Formula (I′) methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

公开(公告)号：US11542265B2

公开(公告)日：2023-01-03

申请号：US17238494

申请日：2021-04-23

申请人： Incyte Corporation

发明人： Oleg Vechorkin ,  Kai Liu ,  Jun Pan ,  Alexander Sokolsky ,  Hai Fen Ye ,  Qinda Ye ,  Wenqing Yao ,  Joshua Hummel

IPC分类号： A61K31/519 ,  A61P35/00 ,  C07D487/04

摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

公开(公告)号：US11427592B2

公开(公告)日：2022-08-30

申请号：US16720935

申请日：2019-12-19

申请人： Incyte Corporation

发明人： Jun Pan ,  Jeremy Roach ,  Song Mei ,  Chunhong He ,  Liangxing Wu ,  Wenqing Yao

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61K31/519

摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.

公开(公告)号：US20220002299A1

公开(公告)日：2022-01-06

申请号：US17365686

申请日：2021-07-01

申请人： Incyte Corporation

发明人： Kai Liu ,  Onur Atasoylu ,  Yu Bai ,  Andrew W. Buesking ,  Leah C. Konkol ,  Cheng-Tsung Lai ,  Song Mei ,  Jun Pan ,  Liangxing Wu ,  Wenqing Yao

IPC分类号： C07D471/14 ,  C07D519/00

摘要： The present application provides tricyclic pyridone compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

公开(公告)号：US20210380581A1

公开(公告)日：2021-12-09

申请号：US17143567

申请日：2021-01-07

申请人： Incyte Corporation

发明人： Oleg Vechorkin ,  Jun Pan ,  Kai Liu ,  Alexander Sokolsky ,  Anlai Wang ,  Hai Fen Ye ,  Qinda Ye ,  Wenqing Yao

IPC分类号： C07D471/04 ,  C07D519/00

摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

公开(公告)号：US20190382380A1

公开(公告)日：2019-12-19

申请号：US16278865

申请日：2019-02-19

申请人： Incyte Corporation

发明人： Oleg Vechorkin ,  Jun Pan ,  Alexander Sokolsky ,  Evan Styduhar ,  Qinda Ye ,  Wenqing Yao

IPC分类号： C07D403/14 ,  C07D487/08 ,  C07D403/12 ,  C07D487/04 ,  C07D413/12 ,  C07D401/14 ,  C07D401/12 ,  C07D239/26 ,  C07D413/14

摘要： Disclosed are compounds of Formula (I′) methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

公开(公告)号：US20190209537A1

公开(公告)日：2019-07-11

申请号：US16298601

申请日：2019-03-11

申请人： Incyte Corporation ,  Incyte Holdings Corporation

发明人： Chu-Biao Xue ,  Yun-Long Li ,  Hao Feng ,  Jun Pan ,  Anlai Wang ,  Ke Zhang ,  Wenqing Yao ,  Fenglei Zhang ,  Jincong Zhuo

IPC分类号： A61K31/444 ,  C07D491/048 ,  C07D471/04 ,  C07D495/04 ,  C07D405/14 ,  C07D401/14 ,  C07D417/14

摘要： The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.

公开(公告)号：US10280164B2

公开(公告)日：2019-05-07

申请号：US15698768

申请日：2017-09-08

申请人： Incyte Corporation

发明人： Qinda Ye ,  Kai Liu ,  Jun Pan ,  Alexander Sokolsky ,  Oleg Vechorkin ,  Wenqing Yao

IPC分类号： C07D471/04

摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

公开(公告)号：US09676750B2

公开(公告)日：2017-06-13

申请号：US15001826

申请日：2016-01-20

申请人： Incyte Corporation ,  Incyte Holdings Corporation

发明人： Yun-Long Li ,  David M. Burns ,  Hao Feng ,  Chu-Biao Xue ,  Anlai Wang ,  Jun Pan

IPC分类号： C07D471/02 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D498/04 ,  C07D491/048 ,  C07D498/22

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D491/048 ,  C07D498/04 ,  C07D498/22

摘要： The present disclosure describes bicyclic aromatic carboxamide derivatives, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.