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公开(公告)号：US20220281887A1
公开(公告)日：2022-09-08
申请号：US17680002
申请日：2022-02-24
申请人： Incyte Corporation
发明人： Stacey Shepard , Charles Cole , Nikoo Falahatpisheh , Kai Liu , Lixin Shao , Darius Vrubliauskas , Liangxing Wu , Wenqing Yao , Eddy W. Yue
IPC分类号： C07D491/22 , C07D471/22 , C07D471/20 , C07D471/18 , C07D519/00 , A61P35/00
摘要： The present application provides spirocyclic lactam compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.
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公开(公告)号：US11406624B2
公开(公告)日：2022-08-09
申请号：US16518366
申请日：2019-07-22
申请人： Incyte Corporation
发明人： Alexander Sokolsky , Oleg Vechorkin , Kai Liu , Jun Pan , Wenqing Yao , Qinda Ye
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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公开(公告)号：US20220227752A1
公开(公告)日：2022-07-21
申请号：US17558824
申请日：2021-12-22
申请人： Incyte Corporation
发明人： Kai Liu , Jun Pan , Alexander Sokolsky , Oleg Vechorkin , Hai Fen Ye , Qinda Ye , Wenqing Yao
IPC分类号： C07D471/04 , C07D519/00
摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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公开(公告)号：US20210347771A1
公开(公告)日：2021-11-11
申请号：US17119488
申请日：2020-12-11
申请人： Incyte Corporation
发明人： Liangxing Wu , Bo Shen , Jingwei Li , Zhenwu Li , Kai Liu , Fenglei Zhang , Wenqing Yao
IPC分类号： C07D471/04 , C07D487/04
摘要： Disclosed are compounds of Formula (I′), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
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公开(公告)号：US10722495B2
公开(公告)日：2020-07-28
申请号：US16125084
申请日：2018-09-07
申请人： Incyte Corporation
发明人： Oleg Vechorkin , Onur Atasoylu , Hai Fen Ye , Kai Liu , Ke Zhang , Wenqing Yao
IPC分类号： C07D231/56 , A61K31/416 , A61P35/00 , C07D405/14 , C07D405/10 , C07D413/04 , C07D401/14 , C07D403/04 , C07D401/04 , C07D417/04 , A61K31/454
摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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公开(公告)号：US11661422B2
公开(公告)日：2023-05-30
申请号：US17412650
申请日：2021-08-26
申请人： Incyte Corporation
发明人： Kai Liu , Brent Douty , Daniel Levy , Liangxing Wu , Wenqing Yao , Eddy W. Yue
IPC分类号： C07D471/14 , A61K31/519
CPC分类号： C07D471/14 , C07B2200/05
摘要： The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.
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公开(公告)号：US11407749B2
公开(公告)日：2022-08-09
申请号：US17119488
申请日：2020-12-11
申请人： Incyte Corporation
发明人： Liangxing Wu , Bo Shen , Jingwei Li , Zhenwu Li , Kai Liu , Fenglei Zhang , Wenqing Yao
IPC分类号： C07D471/04 , C07D487/04
摘要： Disclosed are compounds of Formula (I′), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
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公开(公告)号：US20220064165A1
公开(公告)日：2022-03-03
申请号：US17412650
申请日：2021-08-26
申请人： Incyte Corporation
发明人： Kai Liu , Brent Douty , Daniel Levy , Liangxing Wu , Wenqing Yao , Eddy W. Yue
IPC分类号： C07D471/14
摘要： The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.
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公开(公告)号：US20210371425A1
公开(公告)日：2021-12-02
申请号：US17238494
申请日：2021-04-23
申请人： Incyte Corporation
发明人： Oleg Vechorkin , Kai Liu , Jun Pan , Alexander Sokolsky , Hai Fen Ye , Qinda Ye , Wenqing Yao , Joshua Hummel
IPC分类号： C07D487/04
摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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公开(公告)号：US20210171518A1
公开(公告)日：2021-06-10
申请号：US17098880
申请日：2020-11-16
申请人： Incyte Corporation
发明人： Joshua Hummel , Oleg Vechorkin , Alexander Sokolsky , Qinda Ye , Kai Liu , Wenqing Yao
IPC分类号： C07D417/14 , A61P35/00 , C07D487/08 , C07D498/08
摘要： Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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