公开(公告)号：US11981671B2

公开(公告)日：2024-05-14

申请号：US17845142

申请日：2022-06-21

申请人： Incyte Corporation

发明人： Joshua Hummel ,  Jingwei Li ,  Ding-Quan Qian ,  Liangxing Wu

IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D519/00

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D519/00

摘要： The present application provides bicyclic amines of Formula (I):




or a pharmaceutically acceptable salt thereof, that are inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.

公开(公告)号：US20230024173A1

公开(公告)日：2023-01-26

申请号：US17816271

申请日：2022-07-29

申请人： Incyte Corporation

发明人： Qinda Ye ,  Jingwei Li ,  Ken Mukai ,  Brandon Smith ,  Liangxing Wu ,  Wenqing Yao ,  Min Ye ,  Yingnan Chen ,  Margaret Favata ,  Yvonne Lo

IPC分类号： C07D401/14 ,  A61P35/00 ,  C07D405/14 ,  C07D413/14 ,  C07D471/08 ,  C07D471/10 ,  C07D498/08

摘要： The present application provides imidazolyl pyrimidinylamine inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.

公开(公告)号：US20210347771A1

公开(公告)日：2021-11-11

申请号：US17119488

申请日：2020-12-11

申请人： Incyte Corporation

发明人： Liangxing Wu ,  Bo Shen ,  Jingwei Li ,  Zhenwu Li ,  Kai Liu ,  Fenglei Zhang ,  Wenqing Yao

IPC分类号： C07D471/04 ,  C07D487/04

摘要： Disclosed are compounds of Formula (I′), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

公开(公告)号：US10308644B2

公开(公告)日：2019-06-04

申请号：US15850170

申请日：2017-12-21

申请人： Incyte Corporation

发明人： Liangxing Wu ,  Jingwei Li ,  Wenqing Yao

IPC分类号： A61K31/4375 ,  C07D413/14 ,  C07D471/04 ,  A61P37/02 ,  C07D498/04 ,  C07D513/04 ,  C07D487/04 ,  C07D413/06 ,  C07D413/12 ,  A61P37/00

摘要： Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

公开(公告)号：US10112950B2

公开(公告)日：2018-10-30

申请号：US15613361

申请日：2017-06-05

申请人： Incyte Corporation

发明人： Liangxing Wu ,  Joel R. Courter ,  Chunhong He ,  Jingwei Li ,  Liang Lu ,  Yaping Sun ,  Xiaozhao Wang ,  Wenqing Yao ,  Colin Zhang ,  Jincong Zhuo

IPC分类号： C07D487/04 ,  C07D519/00

摘要： The present invention is directed to imidazo[1,2-a]pyrazine derivatives of Formula I, or a pharmaceutically acceptable salt thereof, which are LSD1 inhibitors useful in the treatment of diseases such as cancer.

公开(公告)号：US20170145025A1

公开(公告)日：2017-05-25

申请号：US15355494

申请日：2016-11-18

申请人： Incyte Corporation

发明人： Jingwei Li ,  Liangxing Wu ,  Wenqing Yao

IPC分类号： C07D491/048 ,  C07D263/57 ,  C07D413/12 ,  C07D417/10 ,  C07D277/66 ,  C07D413/10 ,  C07D413/14

CPC分类号： C07D491/048 ,  C07D263/57 ,  C07D277/66 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/10 ,  C07D491/04 ,  C07D498/04

摘要： Disclosed are compounds of Formula (I′), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

公开(公告)号：US20230226062A1

公开(公告)日：2023-07-20

申请号：US17952460

申请日：2022-09-26

申请人： Incyte Corporation

发明人： Liangxing Wu ,  Ding-Quan Qian ,  Liang Lu ,  Neil Lajkiewicz ,  Leah C. Konkol ,  Zhenwu Li ,  Fenglei Zhang ,  Jingwei Li ,  Haisheng Wang ,  Meizhong Xu ,  Kaijiong Xiao ,  Wenqing Yao

IPC分类号： A61K31/519 ,  A61K31/4985 ,  A61K31/4725 ,  A61K31/4709 ,  A61K31/445 ,  A61K31/4375 ,  A61K31/437 ,  A61K31/4355 ,  A61K31/429 ,  A61K31/426 ,  A61K31/4196 ,  A61K31/4162 ,  A61K31/4155 ,  A61K31/421 ,  A61K31/404 ,  A61K31/357 ,  A61K31/353 ,  A61K31/133 ,  A61P31/00 ,  A61P35/00 ,  A61K31/5025 ,  C07D513/04 ,  C07D217/04 ,  C07D211/60 ,  C07D403/06 ,  C07D209/44 ,  C07C215/28 ,  C07D495/04 ,  C07D401/06 ,  C07D211/56 ,  C07D217/02 ,  C07D213/74 ,  C07D209/14 ,  C07D311/04 ,  C07D401/12 ,  C07D211/58 ,  C07D471/10 ,  C07C215/08 ,  C07D487/04 ,  C07D295/02 ,  A61P37/00 ,  C07D213/38

CPC分类号： A61K31/519 ,  A61K31/4985 ,  A61K31/4725 ,  A61K31/4709 ,  A61K31/445 ,  A61K31/4375 ,  A61K31/437 ,  A61K31/4355 ,  A61K31/429 ,  A61K31/426 ,  A61K31/4196 ,  A61K31/4162 ,  A61K31/4155 ,  A61K31/421 ,  A61K31/404 ,  A61K31/357 ,  A61K31/353 ,  A61K31/133 ,  A61P31/00 ,  A61P35/00 ,  A61K31/5025 ,  C07D513/04 ,  C07D217/04 ,  C07D211/60 ,  C07D403/06 ,  C07D209/44 ,  C07C215/28 ,  C07D495/04 ,  C07D401/06 ,  C07D211/56 ,  C07D217/02 ,  C07D213/74 ,  C07D209/14 ,  C07D311/04 ,  C07D401/12 ,  C07D211/58 ,  C07D471/10 ,  C07C215/08 ,  C07D487/04 ,  C07D295/02 ,  A61P37/00 ,  C07D213/38 ,  A61K2300/00

摘要： Disclosed are compounds of Formula (I′), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds inhibit PD-1/PD-L1 interaction and are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

公开(公告)号：US20230002376A1

公开(公告)日：2023-01-05

申请号：US17845142

申请日：2022-06-21

申请人： Incyte Corporation

发明人： Joshua Hummel ,  Jingwei Li ,  Ding-Quan Qian ,  Liangxing Wu

IPC分类号： C07D471/04 ,  C07D519/00 ,  C07D487/04

摘要： The present application provides bicyclic amines of Formula (I): or a pharmaceutically acceptable salt thereof, that are inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.

公开(公告)号：US11427567B2

公开(公告)日：2022-08-30

申请号：US16992505

申请日：2020-08-13

申请人： Incyte Corporation

发明人： Qinda Ye ,  Jingwei Li ,  Ken Mukai ,  Brandon Smith ,  Liangxing Wu ,  Wenqing Yao ,  Min Ye ,  Yingnan Chen ,  Margaret Favata ,  Yvonne Lo

IPC分类号： C07D401/14 ,  A61K31/506 ,  A61P35/00 ,  C07D405/14 ,  C07D413/14 ,  C07D471/08 ,  C07D471/10 ,  C07D498/08 ,  C12Q1/6865 ,  C12Q1/6886

摘要： The present application provides imidazolyl pyrimidinylamine inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.

公开(公告)号：US11407749B2

公开(公告)日：2022-08-09

申请号：US17119488

申请日：2020-12-11

申请人： Incyte Corporation

发明人： Liangxing Wu ,  Bo Shen ,  Jingwei Li ,  Zhenwu Li ,  Kai Liu ,  Fenglei Zhang ,  Wenqing Yao

IPC分类号： C07D471/04 ,  C07D487/04

摘要： Disclosed are compounds of Formula (I′), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.