公开(公告)号：US20160168523A1

公开(公告)日：2016-06-16

申请号：US15050356

申请日：2016-02-22

Applicant: Indiana University Research and Technology Corporation

Inventor： James A. GLAZIER ,  Abdelkrim ALILECHE ,  Abbas SHIRINIFARD ,  Dragos AMARIE

IPC: C12M3/00 ,  C12N5/00 ,  A61K35/44 ,  C12M1/00

CPC classification number: C12M21/08 ,  A61K35/44 ,  C12M23/10 ,  C12M23/20 ,  C12N5/0068 ,  C12N2533/90

Abstract: Disclosed herein are capillary fabrication devices comprising living cells within a support medium. Culture of the cells produces viable lumenized capillary networks with natural or pre-determined geometries and ECM and basement membrane associated with the capillary networks. The capillary networks and the ECM and basement membrane detachable from the capillary networks are useful for tissue engineering applications.

Abstract translation: 本文公开了包括支撑介质内的活细胞的毛细管制造装置。 细胞的培养产生具有天然或预定几何形状的可行的管腔毛细血管网络，以及与毛细管网络相关联的ECM和基底膜。 毛细管网络和可从毛细管网络拆卸的ECM和基底膜可用于组织工程应用。