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公开(公告)号：US20190017963A1
公开(公告)日：2019-01-17
申请号：US16026762
申请日：2018-07-03
Inventor： David Edward Clemmer , Michael A. Ewing
IPC: G01N27/62
Abstract: An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field sources may each be coupled to one or more of the plurality of drift tube segments. A control circuit is configured to control operation of the number of the electric field sources in a manner that sequentially applies electric fields to the drift tube segments with a magnitude of at least one being different than the others to allow only ions having a predefined ion mobility or range of ion mobilities to travel through the drift tube. Alternatively, the length of at least one of the drift tube segments may be made different from those of the others to produce the same result. The drift tube segments may define a linear drift tube or a closed drift tube with a continuous ion travel path.
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公开(公告)号：US09368333B2
公开(公告)日：2016-06-14
申请号：US14815313
申请日：2015-07-31
Inventor： David Edward Clemmer , Michael A Ewing , Steven M. Zucker , Christopher R. P. Conant
CPC classification number: G01N27/622 , H01J49/0031 , H01J49/26
Abstract: In a drift tube partitioned into a plurality of cascaded drift tube segments each followed by an ion elimination region, a method of separating ions as a function of ion mobility includes repeatedly, and alternating between at least two different time durations, establishing electric drift fields in the drift tube segments and in some of the ion elimination regions while establishing electric repulsive fields in others of the ion elimination regions such that ions having a predefined mobility or range of mobilities are transmitted through the drift tube at one or more frequencies which include one or more overtones of a fundamental frequency at which ions having the predefined mobility or range of mobilities are transmitted through the drift tube with the electric drift fields and electric repulsive fields repeatedly established with uniform time durations.
Abstract translation: 在分隔成多个级联漂移管段的漂移管中，每个随后都有一个离子消除区，离子迁移的函数之间分离离子的方法包括重复地在至少两个不同的时间间隔之间进行交替，建立电漂移场 漂移管段和一些离子消除区域，同时在其他离子消除区域中建立电排斥场，使得具有预定迁移率或迁移率范围的离子以一个或多个频率透过漂移管，其包括一个或多个 具有预定迁移率或迁移率范围的离子通过漂移管传播的基频的更多泛音，电漂移场和电排斥场以均匀的时间持续时间重复建立。
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公开(公告)号：US20160216236A1
公开(公告)日：2016-07-28
申请号：US15087255
申请日：2016-03-31
Inventor： David Edward Clemmer , Michael A. Ewing , Steven M. Zucker , Christopher R. P. Conant
CPC classification number: G01N27/622 , H01J49/0031 , H01J49/26
Abstract: In a linear drift tube partitioned into a plurality of cascaded drift tube segments each followed by an ion elimination region, a system and method of separating ions includes repeatedly establishing electric drift fields in the drift tube segments and in some of the ion elimination regions while establishing electric repulsive fields in others of the ion elimination regions such that ions having a predefined mobility or range of mobilities are transmitted through the drift tube in one direction, and when the ions reach the end of the drift tube the electric drift fields are reversed and the process is repeated to transmit the ions to the opposite end of the drift tube. Ions may be made to pass back and forth through the drift tube any number of times before being drawn out of the drift tube to an ion detector or into another drift tube.
Abstract translation: 在分离成多个级联的漂移管段的线性漂移管中，每个随后都有离子消除区，分离离子的系统和方法包括在建立漂移管段和一些离子消除区域中重复建立电漂移场 离子消除区域的其他电斥斥场，使得具有预定迁移率或迁移率范围的离子在一个方向上透过漂移管，当离子到达漂移管的末端时，电漂移场相反，并且 重复处理以将离子传输到漂移管的相对端。 任何次数的离子可以在漂移管被抽出离子检测器或另一个漂移管之前来回穿过漂移管。
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公开(公告)号：US20150338374A1
公开(公告)日：2015-11-26
申请号：US14815313
申请日：2015-07-31
Inventor： David Edward Clemmer , Michael A. Ewing , Steven M. Zucker , Christopher R. P. Conant
CPC classification number: G01N27/622 , H01J49/0031 , H01J49/26
Abstract: In a drift tube partitioned into a plurality of cascaded drift tube segments each followed by an ion elimination region, a method of separating ions as a function of ion mobility includes repeatedly, and alternating between at least two different time durations, establishing electric drift fields in the drift tube segments and in some of the ion elimination regions while establishing electric repulsive fields in others of the ion elimination regions such that ions having a predefined mobility or range of mobilities are transmitted through the drift tube at one or more frequencies which include one or more overtones of a fundamental frequency at which ions having the predefined mobility or range of mobilities are transmitted through the drift tube with the electric drift fields and electric repulsive fields repeatedly established with uniform time durations.
Abstract translation: 在分隔成多个级联漂移管段的漂移管中，每个随后都有一个离子消除区，离子迁移的函数之间分离离子的方法包括重复地在至少两个不同的时间间隔之间进行交替，建立电漂移场 漂移管段和一些离子消除区域，同时在其他离子消除区域中建立电排斥场，使得具有预定迁移率或迁移率范围的离子以一个或多个频率透过漂移管，其包括一个或多个 具有预定迁移率或迁移率范围的离子通过漂移管传播的基频的更多泛音，电漂移场和电排斥场以均匀的时间持续时间重复建立。
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公开(公告)号：US20130292562A1
公开(公告)日：2013-11-07
申请号：US13844901
申请日：2013-03-16
Inventor： David Edward Clemmer , Michael A. Ewing , Steven M. Zucker , Christopher R. P. Conant
IPC: G01N27/62
CPC classification number: G01N27/622 , H01J49/0031 , H01J49/26
Abstract: An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field activation sources may each be coupled to one or more of the plurality of drift tube segments. A control circuit is configured to control operation of the number of electric field activation sources in a manner that sequentially applies electric fields to the drift tube segments with a activation duration of at least one of the electric field activation sources different than that of the others to allow only ions having a predefined ion mobility or range of ion mobilities to travel through the drift tube. The drift tube segments may define a linear drift tube or a closed drift tube with a continuous ion travel path.
Abstract translation: 离子迁移谱仪具有漂移管，其被分隔成多个级联漂移管段。 多个电场激活源可以各自耦合到多个漂移管段中的一个或多个。 控制电路被配置为以对于至少一个电场激活源的激活持续时间不同于其他电场激活源的激活持续时间顺序地向漂移管段施加电场的方式来控制电场激活源的数量的操作， 仅允许具有预定离子迁移率或离子迁移率范围的离子穿过漂移管。 漂移管段可以限定具有连续离子行进路径的线性漂移管或闭合漂移管。
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Patent Agency Ranking
公开(公告)号：US09810664B2
公开(公告)日：2017-11-07
申请号：US15087255
申请日：2016-03-31
Inventor： David Edward Clemmer , Michael A. Ewing , Steven M. Zucker , Christopher R. P. Conant
CPC classification number: G01N27/622 , H01J49/0031 , H01J49/26
Abstract: In a linear drift tube partitioned into a plurality of cascaded drift tube segments each followed by an ion elimination region, a system and method of separating ions includes repeatedly establishing electric drift fields in the drift tube segments and in some of the ion elimination regions while establishing electric repulsive fields in others of the ion elimination regions such that ions having a predefined mobility or range of mobilities are transmitted through the drift tube in one direction, and when the ions reach the end of the drift tube the electric drift fields are reversed and the process is repeated to transmit the ions to the opposite end of the drift tube. Ions may be made to pass back and forth through the drift tube any number of times before being drawn out of the drift tube to an ion detector or into another drift tube.
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公开(公告)号：US20170191963A1
公开(公告)日：2017-07-06
申请号：US15465357
申请日：2017-03-21
Inventor： David Edward Clemmer , Michael A. Ewing
IPC: G01N27/62
CPC classification number: G01N27/622
Abstract: An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field sources may each be coupled to one or more of the plurality of drift tube segments. A control circuit is configured to control operation of the number of the electric field sources in a manner that sequentially applies electric fields to the drift tube segments with a magnitude of at least one being different than the others to allow only ions having a predefined ion mobility or range of ion mobilities to travel through the drift tube. Alternatively, the length of at least one of the drift tube segments may be made different from those of the others to produce the same result. The drift tube segments may define a linear drift tube or a closed drift tube with a continuous ion travel path.
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公开(公告)号：US08872102B2
公开(公告)日：2014-10-28
申请号：US13844901
申请日：2013-03-16
Inventor： David Edward Clemmer , Michael A Ewing , Steven M Zucker , Christopher R. P. Conant
CPC classification number: G01N27/622 , H01J49/0031 , H01J49/26
Abstract: An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field activation sources may each be coupled to one or more of the plurality of drift tube segments. A control circuit is configured to control operation of the number of electric field activation sources in a manner that sequentially applies electric fields to the drift tube segments with a activation duration of at least one of the electric field activation sources different than that of the others to allow only ions having a predefined ion mobility or range of ion mobilities to travel through the drift tube. The drift tube segments may define a linear drift tube or a closed drift tube with a continuous ion travel path.
Abstract translation: 离子迁移谱仪具有漂移管，其被分隔成多个级联漂移管段。 多个电场激活源可以各自耦合到多个漂移管段中的一个或多个。 控制电路被配置为以对于至少一个电场激活源的激活持续时间不同于其他电场激活源的激活持续时间顺序地向漂移管段施加电场的方式来控制电场激活源的数量的操作， 仅允许具有预定离子迁移率或离子迁移率范围的离子穿过漂移管。 漂移管段可以限定具有连续离子行进路径的线性漂移管或封闭漂移管。
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公开(公告)号：US10024821B2
公开(公告)日：2018-07-17
申请号：US15465357
申请日：2017-03-21
Inventor： David Edward Clemmer , Michael A. Ewing
IPC: G01N27/62
Abstract: An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field sources may each be coupled to one or more of the plurality of drift tube segments. A control circuit is configured to control operation of the number of the electric field sources in a manner that sequentially applies electric fields to the drift tube segments with a magnitude of at least one being different than the others to allow only ions having a predefined ion mobility or range of ion mobilities to travel through the drift tube. Alternatively, the length of at least one of the drift tube segments may be made different from those of the others to produce the same result. The drift tube segments may define a linear drift tube or a closed drift tube with a continuous ion travel path.
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公开(公告)号：US09129782B2
公开(公告)日：2015-09-08
申请号：US14492468
申请日：2014-09-22
Inventor： David Edward Clemmer , Michael A Ewing , Steven M Zucker , Christopher R. P. Conant
CPC classification number: G01N27/622 , H01J49/0031 , H01J49/26
Abstract: In a drift tube partitioned into a plurality of cascaded drift tube segments each followed by an ion elimination region, for any integer M greater than 1, a method of separating ions repeats the following multiple times to cause only ions entering the drift tube that have a predefined ion mobility or range to traverse the drift tube: for each integer N beginning with 1 and sequentially advancing to M, establishing for a time duration an Nth electric repulsive field in the Nth ion elimination region and in every following Mth ion elimination region and an Nth electric drift field in each remaining ion elimination region and in each drift tube segment while deactivating for the time duration all non-Nth electric drift fields and non-Nth electric repulsive fields in each of the ion elimination regions and drift tube segments.
Abstract translation: 在分隔成多个级联漂移管段的漂移管中，每个后续是离子消除区，对于大于1的任何整数M，分离离子的方法重复以下多次，以使仅有离子进入漂移管具有 预定的离子迁移率或穿越漂移管的范围：对于从1开始并顺序前进到M的每个整数N，建立第N个离子消除区域和每个后续的第M个离子消除区域中的第N个电排斥场的持续时间，以及 在每个剩余的离子消除区域和每个漂移管段中的第N个电漂移场，同时在每个离子消除区域和漂移管段中去除所有非第N个电漂移场和非第N个电排斥场的持续时间。
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