公开(公告)号：US20190017963A1

公开(公告)日：2019-01-17

申请号：US16026762

申请日：2018-07-03

Applicant: Indiana University Research and Technology Corporation

Inventor： David Edward Clemmer ,  Michael A. Ewing

IPC: G01N27/62

Abstract: An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field sources may each be coupled to one or more of the plurality of drift tube segments. A control circuit is configured to control operation of the number of the electric field sources in a manner that sequentially applies electric fields to the drift tube segments with a magnitude of at least one being different than the others to allow only ions having a predefined ion mobility or range of ion mobilities to travel through the drift tube. Alternatively, the length of at least one of the drift tube segments may be made different from those of the others to produce the same result. The drift tube segments may define a linear drift tube or a closed drift tube with a continuous ion travel path.

公开(公告)号：US10024821B2

公开(公告)日：2018-07-17

申请号：US15465357

申请日：2017-03-21

Applicant: Indiana University Research and Technology Corporation

Inventor： David Edward Clemmer ,  Michael A. Ewing

IPC: G01N27/62

Abstract: An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field sources may each be coupled to one or more of the plurality of drift tube segments. A control circuit is configured to control operation of the number of the electric field sources in a manner that sequentially applies electric fields to the drift tube segments with a magnitude of at least one being different than the others to allow only ions having a predefined ion mobility or range of ion mobilities to travel through the drift tube. Alternatively, the length of at least one of the drift tube segments may be made different from those of the others to produce the same result. The drift tube segments may define a linear drift tube or a closed drift tube with a continuous ion travel path.

公开(公告)号：US20170307565A1

公开(公告)日：2017-10-26

申请号：US15606478

申请日：2017-05-26

Applicant: Indiana University Research and Technology Corporation

Inventor： David E. Clemmer ,  Michael A. Ewing

IPC: G01N27/62 ,  H01J49/44 ,  H01J49/26 ,  H01J49/46 ,  H01J49/02

CPC classification number: G01N27/622 ,  H01J49/022 ,  H01J49/26 ,  H01J49/443 ,  H01J49/46

Abstract: A hybrid ion mobility spectrometer includes a single-pass drift tube having an ion inlet and an ion outlet, a multiple-pass drift tube having an ion inlet and an ion outlet each coupled to the single pass drift tube between the ion inlet and the ion outlet thereof, and at least one ion steering channel controllable to selectively pass ions traveling through the single-pass drift tube into the multiple-pass drift tube via the ion inlet of the multiple-pass drift tube and to selectively pass ions traveling through the multiple-pass drift tube into the single-pass drift tube via the ion outlet of the multiple-pass drift tube. The single-pass drift tube separates in time ions traveling therethrough according to a first function of ion mobility, and the multiple-pass drift tube separates in time ions traveling one or more times therethrough according to the first or a second function of ion mobility.

公开(公告)号：US20150041637A1

公开(公告)日：2015-02-12

申请号：US14492468

申请日：2014-09-22

Applicant: Indiana University Research and Technology Corporation

Inventor： David Edward Clemmer ,  Michael A. Ewing ,  Steven M. Zucker ,  Christopher R. P. Conant

IPC: H01J49/00 ,  H01J49/26 ,  G01N27/62

CPC classification number: G01N27/622 ,  H01J49/0031 ,  H01J49/26

Abstract: In a drift tube partitioned into a plurality of cascaded drift tube segments each followed by an ion elimination region, for any integer M greater than 1, a method of separating ions repeats the following multiple times to cause only ions entering the drift tube that have a predefined ion mobility or range to traverse the drift tube: for each integer N beginning with 1 and sequentially advancing to M, establishing for a time duration an Nth electric repulsive field in the Nth ion elimination region and in every following Mth ion elimination region and an Nth electric drift field in each remaining ion elimination region and in each drift tube segment while deactivating for the time duration all non-Nth electric drift fields and non-Nth electric repulsive fields in each of the ion elimination regions and drift tube segments.

Abstract translation: 在分隔成多个级联漂移管段的漂移管中，每个后续是离子消除区，对于大于1的任何整数M，分离离子的方法重复以下多次，以使仅有离子进入漂移管具有 预定的离子迁移率或穿越漂移管的范围：对于从1开始并顺序前进到M的每个整数N，建立第N个离子消除区域和每个后续的第M个离子消除区域中的第N个电排斥场的持续时间，以及 在每个剩余的离子消除区域和每个漂移管段中的第N个电漂移场，同时在每个离子消除区域和漂移管段中去除所有非第N个电漂移场和非第N个电排斥场的持续时间。

公开(公告)号：US20190360964A1

公开(公告)日：2019-11-28

申请号：US16357366

申请日：2019-03-19

Applicant: Indiana University Research and Technology Corporation

Inventor： David E. Clemmer ,  Michael A. Ewing

IPC: G01N27/62 ,  H01J49/02 ,  H01J49/26 ,  H01J49/44 ,  H01J49/46

Abstract: A hybrid ion mobility spectrometer includes a single-pass drift tube having an ion inlet and an ion outlet, a multiple-pass drift tube having an ion inlet and an ion outlet each coupled to the single pass drift tube between the ion inlet and the ion outlet thereof, and at least one ion steering channel controllable to selectively pass ions traveling through the single-pass drift tube into the multiple-pass drift tube via the ion inlet of the multiple-pass drift tube and to selectively pass ions traveling through the multiple-pass drift tube into the single-pass drift tube via the ion outlet of the multiple-pass drift tube. The single-pass drift tube separates in time ions traveling therethrough according to a first function of ion mobility, and the multiple-pass drift tube separates in time ions traveling one or more times therethrough according to the first or a second function of ion mobility.

公开(公告)号：US09810664B2

公开(公告)日：2017-11-07

申请号：US15087255

申请日：2016-03-31

Applicant: Indiana University Research and Technology Corporation

Inventor： David Edward Clemmer ,  Michael A. Ewing ,  Steven M. Zucker ,  Christopher R. P. Conant

IPC: H01J49/00 ,  G01N27/62 ,  H01J49/26

CPC classification number: G01N27/622 ,  H01J49/0031 ,  H01J49/26

Abstract: In a linear drift tube partitioned into a plurality of cascaded drift tube segments each followed by an ion elimination region, a system and method of separating ions includes repeatedly establishing electric drift fields in the drift tube segments and in some of the ion elimination regions while establishing electric repulsive fields in others of the ion elimination regions such that ions having a predefined mobility or range of mobilities are transmitted through the drift tube in one direction, and when the ions reach the end of the drift tube the electric drift fields are reversed and the process is repeated to transmit the ions to the opposite end of the drift tube. Ions may be made to pass back and forth through the drift tube any number of times before being drawn out of the drift tube to an ion detector or into another drift tube.

公开(公告)号：US20170191963A1

公开(公告)日：2017-07-06

申请号：US15465357

申请日：2017-03-21

Applicant: Indiana University Research and Technology Corporation

Inventor： David Edward Clemmer ,  Michael A. Ewing

IPC: G01N27/62

CPC classification number: G01N27/622

Abstract: An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field sources may each be coupled to one or more of the plurality of drift tube segments. A control circuit is configured to control operation of the number of the electric field sources in a manner that sequentially applies electric fields to the drift tube segments with a magnitude of at least one being different than the others to allow only ions having a predefined ion mobility or range of ion mobilities to travel through the drift tube. Alternatively, the length of at least one of the drift tube segments may be made different from those of the others to produce the same result. The drift tube segments may define a linear drift tube or a closed drift tube with a continuous ion travel path.

公开(公告)号：US09683965B2

公开(公告)日：2017-06-20

申请号：US15023575

申请日：2014-09-23

Applicant: Indiana University Research and Technology Corporation

Inventor： David E. Clemmer ,  Michael A. Ewing

IPC: H01J49/00 ,  G01N27/62

CPC classification number: G01N27/622

Abstract: A hybrid ion mobility spectrometer includes a single-pass drift tube having an ion inlet at one end and an ion outlet at an opposite end, a multiple-pass drift tube having an ion inlet and an ion outlet each coupled to the single pass drift tube between the ion inlet and the ion outlet thereof, and a set of ion gates each controllable between an open position to pass ions therethrough and a closed position to block ions from passing therethrough. The set of ion gates may be controlled to pass at least some ions traveling through the single-pass drift tube into the multiple-pass drift tube via the ion inlet of the multiple-pass drift tube and to pass at least some ions traveling through the multiple-pass drift tube into the single-pass drift tube via the ion outlet of the multiple-pass drift tube.

公开(公告)号：US10234423B2

公开(公告)日：2019-03-19

申请号：US15606478

申请日：2017-05-26

Applicant: Indiana University Research and Technology Corporation

Inventor： David E. Clemmer ,  Michael A. Ewing

IPC: H01J49/00 ,  G01N27/62 ,  H01J49/26 ,  H01J49/44 ,  H01J49/46 ,  H01J49/02

Abstract: A hybrid ion mobility spectrometer includes a single-pass drift tube having an ion inlet and an ion outlet, a multiple-pass drift tube having an ion inlet and an ion outlet each coupled to the single pass drift tube between the ion inlet and the ion outlet thereof, and at least one ion steering channel controllable to selectively pass ions traveling through the single-pass drift tube into the multiple-pass drift tube via the ion inlet of the multiple-pass drift tube and to selectively pass ions traveling through the multiple-pass drift tube into the single-pass drift tube via the ion outlet of the multiple-pass drift tube. The single-pass drift tube separates in time ions traveling therethrough according to a first function of ion mobility, and the multiple-pass drift tube separates in time ions traveling one or more times therethrough according to the first or a second function of ion mobility.

公开(公告)号：US20160216236A1

公开(公告)日：2016-07-28

申请号：US15087255

申请日：2016-03-31

Applicant: Indiana University Research and Technology Corporation

Inventor： David Edward Clemmer ,  Michael A. Ewing ,  Steven M. Zucker ,  Christopher R. P. Conant

IPC: G01N27/62 ,  H01J49/00

CPC classification number: G01N27/622 ,  H01J49/0031 ,  H01J49/26

Abstract: In a linear drift tube partitioned into a plurality of cascaded drift tube segments each followed by an ion elimination region, a system and method of separating ions includes repeatedly establishing electric drift fields in the drift tube segments and in some of the ion elimination regions while establishing electric repulsive fields in others of the ion elimination regions such that ions having a predefined mobility or range of mobilities are transmitted through the drift tube in one direction, and when the ions reach the end of the drift tube the electric drift fields are reversed and the process is repeated to transmit the ions to the opposite end of the drift tube. Ions may be made to pass back and forth through the drift tube any number of times before being drawn out of the drift tube to an ion detector or into another drift tube.

Abstract translation: 在分离成多个级联的漂移管段的线性漂移管中，每个随后都有离子消除区，分离离子的系统和方法包括在建立漂移管段和一些离子消除区域中重复建立电漂移场 离子消除区域的其他电斥斥场，使得具有预定迁移率或迁移率范围的离子在一个方向上透过漂移管，当离子到达漂移管的末端时，电漂移场相反，并且 重复处理以将离子传输到漂移管的相对端。 任何次数的离子可以在漂移管被抽出离子检测器或另一个漂移管之前来回穿过漂移管。