公开(公告)号：US20100100143A1

公开(公告)日：2010-04-22

申请号：US12254728

申请日：2008-10-20

申请人： Indra B. Nigam ,  Dirk Muessig ,  Hannes Kraetschmer

发明人： Indra B. Nigam ,  Dirk Muessig ,  Hannes Kraetschmer

IPC分类号： A61N1/39 ,  A61N1/365

CPC分类号： A61N1/3704 ,  A61B5/042 ,  A61B5/046 ,  A61B5/0468 ,  A61B5/6846 ,  A61N1/395

摘要： Device for classifying tachyarrhythmia that obtains pre-defined values, monitors atrial intervals and compares lengths of each interval with pre-defined value IL, stores length of atrial interval if length is shorter than IL, in case X of most recent Y number of atrial intervals have length shorter than IL, evaluates most recent =1 criteria, and controls a cardiac device depending on the classification. Atrial intervals are first evaluated by using the “X-out-of-Y” criterion and subsequently checked for stability after an atrial tachyarrhythmia is detected using “X-out-of-Y” criterion. For stability check, only intervals found shorter than the interval limit are used. Check is based on interval-to-interval comparison rather than as generally practiced, comparisons of individual intervals with the minimum or average of all intervals.

摘要翻译： 用于分类获得预定值的快速性心律失常的装置，监测心房间隔并且将每个间隔的长度与预定义值IL进行比较，如果长度短于IL，则存储心房间隔的长度，在最近的Y个心房间隔的情况下 长度短于IL，评估最近的<= N心房间隔，长度 = 1标准，则将心房快速性心律失常分类为稳定，并根据 分类。 首先通过使用“X-out-Y”标准来评估心房间隔，并随后在使用“X-out-of-Y”标准检测到房性快速性心律失常之后检查其稳定性。 对于稳定性检查，仅使用间隔时间间隔短于间隔限制。 检查是基于间隔间隔比较而不是通常实践的，将各个间隔与所有间隔的最小值或平均值进行比较。

公开(公告)号：US20080140146A1

公开(公告)日：2008-06-12

申请号：US11567753

申请日：2006-12-07

申请人： Garth GARNER ,  Hannes Kraetschmer ,  Dirk Muessig ,  Indra B. Nigam

发明人： Garth GARNER ,  Hannes Kraetschmer ,  Dirk Muessig ,  Indra B. Nigam

IPC分类号： A61N1/362

CPC分类号： A61N1/3712

摘要： A heart stimulator provides a reliable automatic capture threshold search feature. A stimulation pulse generator is connected to at least a ventricular stimulation electrode for delivering electric stimulation pulses to at least the ventricle of the heart. The stimulation pulses generated have a strength depending on a control signal. A sensing stage is connected to an electrode for picking up electric potentials inside at least said ventricle of a heart and a control unit connected to the sensing stage and to the stimulation pulse generator determines points of time for scheduling stimulation pulses, to trigger the stimulation pulse generator so as to deliver a stimulation pulse when scheduled and to put out control signals for controlling the strength of the stimulation pulse. The control unit is further adapted to perform a capture analysis which may take into account extraordinary events.

摘要翻译： 心脏刺激器提供可靠的自动捕获阈值搜索功能。 刺激脉冲发生器连接到至少一个心室刺激电极，用于将电刺激脉冲传送到至少心脏的心室。 产生的刺激脉冲具有取决于控制信号的强度。 感测级连接到用于拾取心脏的至少所述心室内的电位的电极和连接到感测级的控制单元，并且刺激脉冲发生器确定调度刺激脉冲的时间点，以触发刺激脉冲 发生器，以便在调度时传递刺激脉冲，并且输出用于控制刺激脉冲的强度的控制信号。 控制单元还适于执行可以考虑特殊事件的捕获分析。

公开(公告)号：US08024031B2

公开(公告)日：2011-09-20

申请号：US12254728

申请日：2008-10-20

申请人： Indra B. Nigam ,  Dirk Muessig ,  Hannes Kraetschmer

发明人： Indra B. Nigam ,  Dirk Muessig ,  Hannes Kraetschmer

IPC分类号： A61B5/04

CPC分类号： A61N1/3704 ,  A61B5/042 ,  A61B5/046 ,  A61B5/0468 ,  A61B5/6846 ,  A61N1/395

摘要： Device for classifying tachyarrhythmia that obtains pre-defined values, monitors atrial intervals and compares lengths of each interval with pre-defined value IL, stores length of atrial interval if length is shorter than IL, in case X of most recent Y number of atrial intervals have length shorter than IL, evaluates most recent =1 criteria, and controls a cardiac device depending on the classification. Atrial intervals are first evaluated by using the “X-out-of-Y” criterion and subsequently checked for stability after an atrial tachyarrhythmia is detected using “X-out-of-Y” criterion. For stability check, only intervals found shorter than the interval limit are used. Check is based on interval-to-interval comparison rather than as generally practiced, comparisons of individual intervals with the minimum or average of all intervals.

摘要翻译： 用于分类获得预定义值的快速性心律失常的装置，监测心房间隔并且将每个间隔的长度与预定义值IL进行比较，如果长度短于IL，则存储心房间隔的长度，在最近的Y个心房间隔的情况下 长度短于IL，评估最近的<= N心房间隔，长度 = 1标准，则将心房快速性心律失常分类为稳定，并根据 分类。 首先通过使用“X-out-Y”标准来评估心房间隔，并随后在使用“X-out-of-Y”标准检测到房性快速性心律失常之后检查其稳定性。 对于稳定性检查，仅使用间隔时间间隔短于间隔限制。 检查是基于间隔间隔比较而不是通常实践的，将各个间隔与所有间隔的最小值或平均值进行比较。

公开(公告)号：US07580748B2

公开(公告)日：2009-08-25

申请号：US11567753

申请日：2006-12-07

申请人： Garth Garner ,  Hannes Kraetschmer ,  Dirk Muessig ,  Indra B. Nigam

发明人： Garth Garner ,  Hannes Kraetschmer ,  Dirk Muessig ,  Indra B. Nigam

IPC分类号： A61N1/00

CPC分类号： A61N1/3712

摘要： A heart stimulator provides a reliable automatic capture threshold search feature. A stimulation pulse generator is connected to at least a ventricular stimulation electrode for delivering electric stimulation pulses to at least the ventricle of the heart. The stimulation pulses generated have a strength depending on a control signal. A sensing stage is connected to an electrode for picking up electric potentials inside at least said ventricle of a heart and a control unit connected to the sensing stage and to the stimulation pulse generator determines points of time for scheduling stimulation pulses, to trigger the stimulation pulse generator so as to deliver a stimulation pulse when scheduled and to put out control signals for controlling the strength of the stimulation pulse. The control unit is further adapted to perform a capture analysis which may take into account extraordinary events.

摘要翻译： 心脏刺激器提供可靠的自动捕获阈值搜索功能。 刺激脉冲发生器连接到至少一个心室刺激电极，用于将电刺激脉冲传送到至少心脏的心室。 产生的刺激脉冲具有取决于控制信号的强度。 感测级连接到用于拾取心脏的至少所述心室内的电位的电极和连接到感测级的控制单元，并且刺激脉冲发生器确定调度刺激脉冲的时间点，以触发刺激脉冲 发生器，以便在调度时传递刺激脉冲，并且输出用于控制刺激脉冲的强度的控制信号。 控制单元还适于执行可以考虑特殊事件的捕获分析。

公开(公告)号：US08190247B2

公开(公告)日：2012-05-29

申请号：US12579305

申请日：2009-10-14

申请人： Indra B. Nigam ,  Dirk Muessig

发明人： Indra B. Nigam ,  Dirk Muessig

IPC分类号： A61B5/04

CPC分类号： A61N1/3704 ,  A61B5/042 ,  A61B5/046 ,  A61B5/0468 ,  A61B5/6846 ,  A61N1/395

摘要： Method for detecting cardiac events, e.g., Atrial Fibrillation (AF) or termination of AF. Based on analysis of the instability observed in heart rate, caused by irregular conduction from the atrium during AF. Change in heart interval is monitored on beat-to-beat basis to recognize instability that indicates presence of AF or Atrial Flutter. A packet of a number of consecutive intervals is evaluated, whether the length of an interval is stable compared with the length of the preceding interval, or whether the length of the subsequent interval has changed. After detection of an instability, instability counter is incremented. The result of the stability test for a packet of intervals is represented by the value of the instability counter. Depending upon whether or not an AF already declared, (indicated by AF status flag), different “X-out-of-Y” criterion are applied. AF status flag set/cleared when declaring AF/termination of AF.

摘要翻译： 用于检测心脏事件的方法，例如心房颤动（AF）或AF终止。 基于AF期间心房不规则传导引起的心率不稳定性分析。 以搏动为基础监测心脏间隔的变化，以识别指示存在AF或心房扑动的不稳定性。 评估多个连续间隔的分组，间隔的长度是否与先前间隔的长度相比是稳定的，还是后续间隔的长度是否已经改变。 检测不稳定后，不稳定计数器增加。 一段时间间隔的稳定性测试结果由不稳定性计数器的值表示。 根据AF已经声明的（AF状态标志）是否适用不同的“X-out-of-Y”标准。 声明自动对焦/终止AF时AF状态标志置1 /清除。

公开(公告)号：US6061592A

公开(公告)日：2000-05-09

申请号：US73829

申请日：1998-05-06

申请人： Indra B. Nigam

发明人： Indra B. Nigam

IPC分类号： A61B5/0464 ,  A61N1/362 ,  A61B5/04 ,  A61B5/0402

CPC分类号： A61B5/7264 ,  A61B5/0464 ,  A61N1/3622

摘要： A device for detecting pathological tachycardia, in particular for use with an implantable device for terminating tachycardias, having a classifican device, responding to at least one electrical signal derived from the heart, which if the classification criterion is met outputs an output signal indicating pathological tachycardia, having a plurality of classification devices for checking various classification criteria within one heart interval or on the basis of the evaluation of preceding heart intervals; a controllable counter that is connected to the outputs of the classification devices via first logic means; means for incrementing the counter state of the counter by a predetermined counting amount each time, if during a heart interval at least one of the primary classification signals appears; means for keeping the counter state constant or decrementing it by a predetermined counting amount, if no primary classification signal appears within the heart interval; and discriminator means, which output the output signal indicating the occurrence of pathological tachycardia if the counter state of the counter exceeds a predetermined value.

摘要翻译： 一种用于检测病理性心动过速的装置，特别是用于终止心动过速的可植入装置，具有对来自心脏的至少一个电信号进行响应的分类装置，如果符合分类标准则输出指示病理性心动过速的输出信号 具有多个用于在一个心脏间隔内检查各种分类标准的分类装置，或者基于先前的心脏间隔的评估; 可控计数器，经由第一逻辑装置连接到分类装置的输出; 如果在心脏间隔期间出现至少一个主分类信号，则每次增加计数器的计数器状态预定计数量的装置; 如果在心脏区间内没有出现主分类信号，则保持计数器状态恒定或减小预定计数量的装置; 以及鉴别器装置，如果计数器的计数器状态超过预定值，则其输出指示出现病理性心动过速的输出信号。

公开(公告)号：US20110125043A1

公开(公告)日：2011-05-26

申请号：US12941442

申请日：2010-11-08

申请人： Indra B. Nigam

发明人： Indra B. Nigam

IPC分类号： A61B5/04

CPC分类号： A61B5/0456 ,  A61B5/04012 ,  A61B5/7221

摘要： The present disclosure generally relates to a method, a device, and a computer-readable storage medium for detecting heart beats from cardiac signals whose quality, expressed in terms of signal amplitude and signal-to-noise ratio, varies dynamically in time.Hence, a method, a device, and a computer-readable storage medium for detecting electrical signals originating from a human or animal heart is proposed. The method includes the following steps: a) identifying an initial indication of the event in at least one of the signal channels, b) deciding whether or not the identified initial indication confirms the event depending on the quality of the signal channels in which initial indications are identified; and c) determining a point-of-detection for the event depending on the quality of the signal channels and depending from the shape of the signal.

摘要翻译： 本公开总体上涉及一种用于从心脏信号检测心跳的方法，装置和计算机可读存储介质，其质量以信号幅度和信噪比表示，其时间动态变化。 因此，提出了一种用于检测源自人或动物心脏的电信号的方法，装置和计算机可读存储介质。 该方法包括以下步骤：a）在至少一个信号信道中识别事件的初始指示，b）根据信号信道的质量判定所识别的初始指示是否确认事件，其中初始指示 被识别 以及c）根据信号通道的质量并根据信号的形状确定事件的检测点。

公开(公告)号：US20080125665A1

公开(公告)日：2008-05-29

申请号：US11563317

申请日：2006-11-27

申请人： Indra B. Nigam

发明人： Indra B. Nigam

IPC分类号： A61N1/372 ,  A61B5/0402

CPC分类号： A61B5/04021 ,  A61B5/0006 ,  A61B5/7232 ,  A61N1/368 ,  A61N1/3704

摘要： An implantable medical device provides for improved storage of recorded IEGMs. A sensing stage is connected to an electrode for picking up electric potentials from inside a heart, the time course of said electric potentials representing a heart signal, a control unit connected to said sensing stage is adapted to process a sequence of data points that each represent an amplitude or magnitude A of a time-varying signal at equidistant points of time t, wherein end points of data segments are determined by processing of the sequence of data points. The control unit is adapted to identify end points of data segments by processing of the sequence of data points.

摘要翻译： 可植入医疗设备提供记录的IEGM的改进存储。 感测级连接到用于从心脏内部拾取电位的电极，表示心脏信号的所述电位的时间过程，连接到所述感测级的控制单元适于处理每个代表的数据点的序列 在时间点t的等距点处的时变信号的振幅或幅度A，其中数据段的端点由数据点序列的处理确定。 控制单元适于通过处理数据点序列来识别数据段的端点。

公开(公告)号：US5978700A

公开(公告)日：1999-11-02

申请号：US73345

申请日：1998-05-06

申请人： Indra B. Nigam

发明人： Indra B. Nigam

IPC分类号： A61B5/0464 ,  G06F17/00

CPC分类号： A61B5/0464 ,  A61B5/0422

摘要： An apparatus for detecting ventricular tachycardia includes a first and snd calculation unit, each having an input side connected to a ventricle sensor and an atrium sensor, respectively, and to a timer, for calculating the R--R and P--P intervals between respective successive electrical activities in the atrium and in the ventricle. A threshold value memory stores at least one threshold value for the R--R intervals in memory. A first comparator unit compares the R--R intervals with the at least one threshold value. A first and second interval memory store a predetermined number of calculated R--R and P--P intervals, respectively, or mean R--R and mean P--P interval values. A second comparator unit compares the P--P intervals with the R--R intervals. A third and fourth calculation unit, connected to the output of the first and second calculation unit and/or of the first and second interval memory unit, respectively, calculate the change over time between successive P--P and R--R intervals. First and second criterion memories stores predetermined stability criterion for the change over time between successive P--P and R--R intervals, respectively. A third and fourth comparator unit compare the calculated change over time in the P--P and R--R intervals with the associated stability criterion stored in memory.

摘要翻译： 一种用于检测室性心动过速的装置包括第一和第二计算单元，每个单元具有分别连接到心室传感器和心房传感器的输入侧以及定时器，用于计算在所述计时器中的相应的连续电活动之间的RR和PP间隔 心房和心室。 阈值存储器存储存储器中的R-R间隔的至少一个阈值。 第一比较器单元将R-R间隔与至少一个阈值进行比较。 第一和第二间隔存储器分别存储预定数量的计算的R-R和P-P间隔，或平均值R-R和平均P-P间隔值。 第二比较器单元将P-P间隔与R-R间隔进行比较。 分别连接到第一和第二计算单元和/或第一和第二间隔存储单元的输出的第三和第四计算单元计算连续的P-P和R-R间隔之间随时间的变化。 第一和第二标准存储器分别存储在连续P-P和R-R间隔之间随时间变化的预定稳定性标准。 第三和第四比较器单元将所计算的P-P和R-R间隔的变化与存储在存储器中的相关稳定性标准进行比较。

公开(公告)号：US08880162B2

公开(公告)日：2014-11-04

申请号：US12941442

申请日：2010-11-08

申请人： Indra B. Nigam

发明人： Indra B. Nigam

IPC分类号： A61B5/04 ,  A61B5/0456 ,  A61B5/00

CPC分类号： A61B5/0456 ,  A61B5/04012 ,  A61B5/7221

摘要： The present disclosure generally relates to a method, a device, and a computer-readable storage medium for detecting heart beats from cardiac signals whose quality, expressed in terms of signal amplitude and signal-to-noise ratio, varies dynamically in time.Hence, a method, a device, and a computer-readable storage medium for detecting electrical signals originating from a human or animal heart is proposed. The method includes the following steps: a) identifying an initial indication of the event in at least one of the signal channels, b) deciding whether or not the identified initial indication confirms the event depending on the quality of the signal channels in which initial indications are identified; and c) determining a point-of-detection for the event depending on the quality of the signal channels and depending from the shape of the signal.

摘要翻译： 本公开总体上涉及一种用于从心脏信号检测心跳的方法，装置和计算机可读存储介质，其质量以信号幅度和信噪比表示，其时间动态变化。 因此，提出了一种用于检测源自人或动物心脏的电信号的方法，装置和计算机可读存储介质。 该方法包括以下步骤：a）在至少一个信号信道中识别事件的初始指示，b）根据信号信道的质量判定所识别的初始指示是否确认事件，其中初始指示 被识别 以及c）根据信号通道的质量并根据信号的形状确定事件的检测点。