公开(公告)号：US07583996B2

公开(公告)日：2009-09-01

申请号：US11560099

申请日：2006-11-15

申请人： Jie Lian ,  Christopher S. de Voir ,  Garth Garner ,  Hannes Kraetschmer ,  Dirk Müssig

发明人： Jie Lian ,  Christopher S. de Voir ,  Garth Garner ,  Hannes Kraetschmer ,  Dirk Müssig

IPC分类号： A61N1/368

CPC分类号： A61N1/3622 ,  A61N1/3624 ,  A61N1/3688

摘要： Heart stimulator that stimulates at least a heart's right atrium and ventricle in an atrium asynchronous stimulation mode with an overdrive stimulation rate. Interposes one resynchronization cycle after a sensed atrial event to regain AV synchrony during otherwise asynchronous stimulation mode. Allows for pacing mode that can pace the atrium with an overdrive stimulation rate in dual-chamber asynchronous mode while maintaining the AV synchrony and is called DDI(R)+. In DDI(R)+, pacemaker performs an atrial asynchronous (V synchronous) pacing mode such as DDI or DDI(R). The overdrive stimulation rate (OSR) is either a fixed rate (programmed by the external device) that is thought to be above the underlying intrinsic atrial rate, or is dynamically adjusted according to the measured atrial cycle length to be slightly above intrinsic atrial rate. The overdrive stimulation rate may be based on an intrinsic atrial rate or on hemodynamic need. DDI(R)+ timing may be ventricle-based.

摘要翻译： 心脏刺激器，可以刺激至少一个心脏异位刺激模式的心脏和心室，具有超速刺激速率。 在感应到的心房事件之后插入一个再同步循环，以在其他异步刺激模式下重新获得AV同步。 允许起搏模式，可以在双室异步模式下以过驱动刺激速率调节心房，同时保持AV同步，称为DDI（R）+。 在DDI（R）+中，起搏器执行心房异步（V同步）起搏模式，如DDI或DDI（R）。 超速刺激速率（OSR）是被认为高于潜在固有心房率的固定比率（由外部设备编程），或根据测量的心房周期长度动态调整为略高于固有心房率。 超速刺激速率可以基于固有心房率或血液动力学需要。 DDI（R）+时间可能是基于心室的。

公开(公告)号：US20110130669A1

公开(公告)日：2011-06-02

申请号：US12954418

申请日：2010-11-24

申请人： Garth Garner ,  Jie Lian ,  Dirk Muessig

发明人： Garth Garner ,  Jie Lian ,  Dirk Muessig

IPC分类号： A61B5/0402

CPC分类号： A61B5/04012 ,  A61B5/04288

摘要： Improving the signal-to-noise ratio of electrocardiogram (ECG) measurements facilitates cardiac beat detection in a human or animal patient. ECG signals measured either on the surface of the skin or subcutaneously from pairs of leads may be combined to calculate a differential signal. The measured signal may also be averaged to produce a second estimate. A point-by-point product of the differential signal and the averaged signal is generated if the sample pair has the same polarity. The product signals feature enhanced signal components and reduced noise components, thus improving the signal-to-noise ratio of the to respective input channels. Product signals are then subjected to peak detection through a conventional auto-sensing approach. Preliminary event detection results from the conditional product signals may then be aggregated, and final sense markers for ECG beat detection may be generated by means of a voting algorithm.

摘要翻译： 提高心电图（ECG）测量的信噪比有助于人或动物患者的心跳检测。 可以组合在皮肤表面或皮下从引线对测量的ECG信号以计算差分信号。 测量的信号也可以被平均以产生第二估计。 如果采样对具有相同的极性，则产生差分信号和平均信号的逐点乘积。 产品信号具有增强的信号分量和降低的噪声分量，从而提高相应输入通道的信噪比。 然后通过传统的自动感测方法对产品信号进行峰值检测。 然后可以聚合来自条件产品信号的初步事件检测结果，并且可以通过投票算法产生用于ECG拍摄检测的最终感测标记。

公开(公告)号：US20090240300A1

公开(公告)日：2009-09-24

申请号：US12210381

申请日：2008-09-15

申请人： Jie Lian ,  Garth Garner ,  Dirk Muessig

发明人： Jie Lian ,  Garth Garner ,  Dirk Muessig

IPC分类号： A61N1/365

CPC分类号： A61B5/04525 ,  A61B5/0464 ,  A61B5/7264

摘要： A device for classifying of supraventricular tachyarrhythmia (SVT) from ventricular tachyarrhythmia (VT) comprising means for providing a template signal and a test signal originated from an electrogram, the template signal and the test signal comprising samples, means for transforming at least the test signal resulting in a representation of the test signal where the sample values of the signal take integers, means for determining a correlation between the template signal and the test signal and means for classifying of SVT from ventricular VT based on the correlation.

摘要翻译： 用于从室性快速性心律失常（VT）分类室上性快速性心律失常（SVT）的装置，包括用于提供源自电描记图的模板信号和测试信号的装置，模板信号和包括样本的测试信号，用于至少转换测试信号的装置 导致测试信号的表示，其中信号的采样值采用整数，用于确定模板信号和测试信号之间的相关性的装置以及用于基于相关性从心室VT分类SVT的装置。

公开(公告)号：US20090240298A1

公开(公告)日：2009-09-24

申请号：US12255516

申请日：2008-10-21

申请人： Jie LIAN ,  Garth Garner ,  Dirk Muessig ,  Volker Lang

发明人： Jie LIAN ,  Garth Garner ,  Dirk Muessig ,  Volker Lang

IPC分类号： A61N1/39 ,  A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/3688

摘要： The invention is directed to a heart stimulator for left-ventricular pacing comprising a left ventricular stimulation pulse generator connected or connectable to a single electrode lead for left ventricular stimulation having one or more electrodes for delivery of stimulation pulses to left ventricular myocardial heart tissue, said stimulation pulse generator being adapted to generate and deliver stimulation pulses of switchable polarity. The heart stimulator further comprises a control unit connected to the stimulation pulse generator for controlling the stimulation pulse generator and to trigger generation and delivery of stimulation pulses having a polarity controlled by said control unit, wherein the control unit is adapted to control said left ventricular stimulation pulse generator so as to deliver at least a pair of suprathreshold stimulation pulses of opposite polarity.

摘要翻译： 本发明涉及用于左心室起搏的心脏刺激器，其包括连接或可连接到用于左心室刺激的单个电极引线的左心室刺激脉冲发生器，其具有用于将刺激脉冲递送至左心室心肌心脏组织的一个或多个电极，所述左心室起搏器 刺激脉冲发生器适于产生和递送可切换极性的刺激脉冲。 心脏刺激器还包括连接到刺激脉冲发生器的控制单元，用于控制刺激脉冲发生器并触发具有由所述控制单元控制的极性的刺激脉冲的产生和传递，其中控制单元适于控制所述左心室刺激 以产生相反极性的至少一对超阈值刺激脉冲。

公开(公告)号：US20090240157A1

公开(公告)日：2009-09-24

申请号：US12368328

申请日：2009-02-10

申请人： Jie Lian ,  Garth Garner ,  Dirk Muessig

发明人： Jie Lian ,  Garth Garner ,  Dirk Muessig

IPC分类号： A61B5/0402

CPC分类号： A61B5/04525 ,  A61B5/7203 ,  A61B5/7264

摘要： An implantable cardiac device, e.g., a pacemaker, defibrillator, cardioverter or biventricular pacing device, that can sense cardiac electrical signals and accurately classify the sensed events. The device provides a template signal and a test signal originated from an electrogram. The device further transforms at least the test signal into a representation of the test signal for example in numerical format where the sample values of the test signal take the form of integers. The device further determines a correlation between the template and test signals, and classifies the sense events based on the correlation. The electrogram may be an intracardiac electrogram (IEGM), atrial electrogram (AEGM), ventricular electrogram (VEGM), surface electrocardiogram (ECG) or subcutaneous electrogram.

摘要翻译： 可植入的心脏装置，例如起搏器，除颤器，心律转复器或双心室起搏装置，其可以感测心脏电信号并且精确地分类所感测到的事件。 该装置提供模板信号和源自电描记图的测试信号。 该装置至少将测试信号转换为测试信号的表示，例如以测试信号的采样值采取整数形式的数字格式。 该装置还确定模板和测试信号之间的相关性，并且基于相关性对感测事件进行分类。 电描记图可以是心内电描记图（IEGM），心房电图（AEGM），心室电图（VEGM），表面心电图（ECG）或皮下电图。

公开(公告)号：US20080300504A1

公开(公告)日：2008-12-04

申请号：US11754973

申请日：2007-05-29

申请人： Sharon Lefkov ,  David F. Hastings ,  Christopher S. de Voir ,  Garth Garner ,  Dirk Muessig ,  Hannes Kraetschmer

发明人： Sharon Lefkov ,  David F. Hastings ,  Christopher S. de Voir ,  Garth Garner ,  Dirk Muessig ,  Hannes Kraetschmer

IPC分类号： A61B5/053

CPC分类号： A61B5/053 ,  A61B5/0538 ,  A61B5/0809 ,  A61B5/4878 ,  A61B5/6846 ,  A61B5/7285 ,  A61N1/36521 ,  A61N1/36585

摘要： Implantable medical device with an impedance determination unit with constant current/voltage source having current feed terminals connected to electrodes for intracorporal placement which generates measuring current pulses having constant current/voltage, for causing a current through a body via intracorporally placed electrodes, a measuring unit for measuring voltage/current strength of voltage/current fed through body, an impedance value determination unit connected to the current/voltage source and adapted to determine an impedance value for each measuring current pulse, and an impedance measuring control and evaluation unit connected to the impedance determination unit which controls the unit and evaluates a sequence of consecutive impedance values, the impedance determination unit further adapted to determine at least intrathoracic and intracardiac impedance values for same period of time, the intrathoracic values sampled with a lower sampling rate than the intracardiac values.

摘要翻译： 具有恒定电流/电压源的阻抗确定单元的植入式医疗装置，其具有连接到用于体内放置的电极的电流馈电端子，其产生具有恒定电流/电压的测量电流脉冲，用于通过体内放置的电极使电流通过身体，测量单元 用于测量通过本体馈送的电压/电流的电压/电流强度，阻抗值确定单元，连接到电流/电压源并适于确定每个测量电流脉冲的阻抗值，以及阻抗测量控制和评估单元，连接到 阻抗确定单元，其控制所述单元并评估连续阻抗值的序列，所述阻抗确定单元还适于在相同时间段内至少确定胸内和心内阻抗值，以比心脏内值更低的采样率采样的胸内值 。

公开(公告)号：US20080140146A1

公开(公告)日：2008-06-12

申请号：US11567753

申请日：2006-12-07

申请人： Garth GARNER ,  Hannes Kraetschmer ,  Dirk Muessig ,  Indra B. Nigam

发明人： Garth GARNER ,  Hannes Kraetschmer ,  Dirk Muessig ,  Indra B. Nigam

IPC分类号： A61N1/362

CPC分类号： A61N1/3712

摘要： A heart stimulator provides a reliable automatic capture threshold search feature. A stimulation pulse generator is connected to at least a ventricular stimulation electrode for delivering electric stimulation pulses to at least the ventricle of the heart. The stimulation pulses generated have a strength depending on a control signal. A sensing stage is connected to an electrode for picking up electric potentials inside at least said ventricle of a heart and a control unit connected to the sensing stage and to the stimulation pulse generator determines points of time for scheduling stimulation pulses, to trigger the stimulation pulse generator so as to deliver a stimulation pulse when scheduled and to put out control signals for controlling the strength of the stimulation pulse. The control unit is further adapted to perform a capture analysis which may take into account extraordinary events.

摘要翻译： 心脏刺激器提供可靠的自动捕获阈值搜索功能。 刺激脉冲发生器连接到至少一个心室刺激电极，用于将电刺激脉冲传送到至少心脏的心室。 产生的刺激脉冲具有取决于控制信号的强度。 感测级连接到用于拾取心脏的至少所述心室内的电位的电极和连接到感测级的控制单元，并且刺激脉冲发生器确定调度刺激脉冲的时间点，以触发刺激脉冲 发生器，以便在调度时传递刺激脉冲，并且输出用于控制刺激脉冲的强度的控制信号。 控制单元还适于执行可以考虑特殊事件的捕获分析。

公开(公告)号：US08380307B2

公开(公告)日：2013-02-19

申请号：US12255516

申请日：2008-10-21

申请人： Jie Lian ,  Garth Garner ,  Dirk Muessig ,  Volker Lang

发明人： Jie Lian ,  Garth Garner ,  Dirk Muessig ,  Volker Lang

IPC分类号： A61N1/00

CPC分类号： A61N1/3627 ,  A61N1/3688

摘要： The invention is directed to a heart stimulator for left-ventricular pacing comprising a left ventricular stimulation pulse generator connected or connectable to a single electrode lead for left ventricular stimulation having one or more electrodes for delivery of stimulation pulses to left ventricular myocardial heart tissue, said stimulation pulse generator being adapted to generate and deliver stimulation pulses of switchable polarity. The heart stimulator further comprises a control unit connected to the stimulation pulse generator for controlling the stimulation pulse generator and to trigger generation and delivery of stimulation pulses having a polarity controlled by said control unit, wherein the control unit is adapted to control said left ventricular stimulation pulse generator so as to deliver at least a pair of suprathreshold stimulation pulses of opposite polarity.

摘要翻译： 本发明涉及用于左心室起搏的心脏刺激器，其包括连接或可连接到用于左心室刺激的单个电极引线的左心室刺激脉冲发生器，其具有用于将刺激脉冲递送至左心室心肌心脏组织的一个或多个电极，所述左心室起搏器 刺激脉冲发生器适于产生和递送可切换极性的刺激脉冲。 心脏刺激器还包括连接到刺激脉冲发生器的控制单元，用于控制刺激脉冲发生器并触发具有由所述控制单元控制的极性的刺激脉冲的产生和传递，其中控制单元适于控制所述左心室刺激 以产生相反极性的至少一对超阈值刺激脉冲。

公开(公告)号：US07970462B2

公开(公告)日：2011-06-28

申请号：US11754973

申请日：2007-05-29

申请人： Sharon Lefkov ,  David F. Hastings ,  Christopher S. de Voir ,  Garth Garner ,  Dirk Muessig ,  Hannes Kraetschmer

发明人： Sharon Lefkov ,  David F. Hastings ,  Christopher S. de Voir ,  Garth Garner ,  Dirk Muessig ,  Hannes Kraetschmer

IPC分类号： A61B5/02 ,  A61B5/08 ,  A61B5/05 ,  A61N1/00

CPC分类号： A61B5/053 ,  A61B5/0538 ,  A61B5/0809 ,  A61B5/4878 ,  A61B5/6846 ,  A61B5/7285 ,  A61N1/36521 ,  A61N1/36585

摘要： Implantable medical device with an impedance determination unit with constant current/voltage source having current feed terminals connected to electrodes for intracorporal placement which generates measuring current pulses having constant current/voltage, for causing a current through a body via intracorporally placed electrodes, a measuring unit for measuring voltage/current strength of voltage/current fed through body, an impedance value determination unit connected to the current/voltage source and adapted to determine an impedance value for each measuring current pulse, and an impedance measuring control and evaluation unit connected to the impedance determination unit which controls the unit and evaluates a sequence of consecutive impedance values, the impedance determination unit further adapted to determine at least intrathoracic and intracardiac impedance values for same period of time, the intrathoracic values sampled with a lower sampling rate than the intracardiac values.

摘要翻译： 具有恒定电流/电压源的阻抗确定单元的植入式医疗装置，其具有连接到用于体内放置的电极的电流馈电端子，其产生具有恒定电流/电压的测量电流脉冲，用于通过体内放置的电极使电流通过身体，测量单元 用于测量通过本体馈送的电压/电流的电压/电流强度，阻抗值确定单元，连接到电流/电压源并适于确定每个测量电流脉冲的阻抗值，以及阻抗测量控制和评估单元，连接到 阻抗确定单元，其控制所述单元并评估连续阻抗值的序列，所述阻抗确定单元还适于在相同时间段内至少确定胸内和心内阻抗值，以比心脏内值更低的采样率采样的胸内值 。

公开(公告)号：US07899520B2

公开(公告)日：2011-03-01

申请号：US12124499

申请日：2008-05-21

申请人： Jie Lian ,  Garth Garner ,  Dirk Muessig ,  Volker Lang

发明人： Jie Lian ,  Garth Garner ,  Dirk Muessig ,  Volker Lang

IPC分类号： A61B5/04

CPC分类号： G06K9/00496 ,  A61N1/3684 ,  A61N1/3712 ,  G06K9/00536

摘要： A medical device having a sensor for sampling a biological signal, the biological signal representing a signal waveform and forming a waveform vector composed of the biological signal samples, and a memory for storing a least two threshold vectors composed of boundary samples representing at least two boundaries related to the biological signal defining subspaces for the biological signal samples. One threshold vector is an upper threshold vector composed of upper boundary samples and the other threshold vector is a lower threshold vector composed of lower boundary samples. An evaluation unit connected to the sensor determines a similarity index (ASCI) by comparing each of the biological signal samples of the waveform vector to corresponding boundary samples of the threshold vectors, thus determining to which subspace each biological signal sample belongs to and creating a trichotomized signal vector, and calculating the signed correlation product of two trichotomized signal vectors.

摘要翻译： 一种具有用于对生物体信号进行采样的传感器的医疗装置，生物信号表示信号波形并形成由生物信号样本构成的波形矢量，以及存储器，用于存储由表示至少两个边界的边界样本组成的至少两个阈值向量 与生物信号样品的生物信号定义子空间有关。 一个阈值向量是由上边界样本组成的上阈值向量，另一阈值向量是由下边界样本组成的下阈值向量。 连接到传感器的评估单元通过将波形向量的生物信号样本与阈值向量的相应边界样本进行比较来确定相似性指数（ASCI），从而确定每个生物信号样本属于哪个子空间并创建三分法 信号向量，并计算两个三分信号向量的有符号相关乘积。