公开(公告)号：US20080140146A1

公开(公告)日：2008-06-12

申请号：US11567753

申请日：2006-12-07

申请人： Garth GARNER ,  Hannes Kraetschmer ,  Dirk Muessig ,  Indra B. Nigam

发明人： Garth GARNER ,  Hannes Kraetschmer ,  Dirk Muessig ,  Indra B. Nigam

IPC分类号： A61N1/362

CPC分类号： A61N1/3712

摘要： A heart stimulator provides a reliable automatic capture threshold search feature. A stimulation pulse generator is connected to at least a ventricular stimulation electrode for delivering electric stimulation pulses to at least the ventricle of the heart. The stimulation pulses generated have a strength depending on a control signal. A sensing stage is connected to an electrode for picking up electric potentials inside at least said ventricle of a heart and a control unit connected to the sensing stage and to the stimulation pulse generator determines points of time for scheduling stimulation pulses, to trigger the stimulation pulse generator so as to deliver a stimulation pulse when scheduled and to put out control signals for controlling the strength of the stimulation pulse. The control unit is further adapted to perform a capture analysis which may take into account extraordinary events.

摘要翻译： 心脏刺激器提供可靠的自动捕获阈值搜索功能。 刺激脉冲发生器连接到至少一个心室刺激电极，用于将电刺激脉冲传送到至少心脏的心室。 产生的刺激脉冲具有取决于控制信号的强度。 感测级连接到用于拾取心脏的至少所述心室内的电位的电极和连接到感测级的控制单元，并且刺激脉冲发生器确定调度刺激脉冲的时间点，以触发刺激脉冲 发生器，以便在调度时传递刺激脉冲，并且输出用于控制刺激脉冲的强度的控制信号。 控制单元还适于执行可以考虑特殊事件的捕获分析。

公开(公告)号：US07580748B2

公开(公告)日：2009-08-25

申请号：US11567753

申请日：2006-12-07

申请人： Garth Garner ,  Hannes Kraetschmer ,  Dirk Muessig ,  Indra B. Nigam

发明人： Garth Garner ,  Hannes Kraetschmer ,  Dirk Muessig ,  Indra B. Nigam

IPC分类号： A61N1/00

CPC分类号： A61N1/3712

摘要： A heart stimulator provides a reliable automatic capture threshold search feature. A stimulation pulse generator is connected to at least a ventricular stimulation electrode for delivering electric stimulation pulses to at least the ventricle of the heart. The stimulation pulses generated have a strength depending on a control signal. A sensing stage is connected to an electrode for picking up electric potentials inside at least said ventricle of a heart and a control unit connected to the sensing stage and to the stimulation pulse generator determines points of time for scheduling stimulation pulses, to trigger the stimulation pulse generator so as to deliver a stimulation pulse when scheduled and to put out control signals for controlling the strength of the stimulation pulse. The control unit is further adapted to perform a capture analysis which may take into account extraordinary events.

摘要翻译： 心脏刺激器提供可靠的自动捕获阈值搜索功能。 刺激脉冲发生器连接到至少一个心室刺激电极，用于将电刺激脉冲传送到至少心脏的心室。 产生的刺激脉冲具有取决于控制信号的强度。 感测级连接到用于拾取心脏的至少所述心室内的电位的电极和连接到感测级的控制单元，并且刺激脉冲发生器确定调度刺激脉冲的时间点，以触发刺激脉冲 发生器，以便在调度时传递刺激脉冲，并且输出用于控制刺激脉冲的强度的控制信号。 控制单元还适于执行可以考虑特殊事件的捕获分析。

公开(公告)号：US20100100143A1

公开(公告)日：2010-04-22

申请号：US12254728

申请日：2008-10-20

申请人： Indra B. Nigam ,  Dirk Muessig ,  Hannes Kraetschmer

发明人： Indra B. Nigam ,  Dirk Muessig ,  Hannes Kraetschmer

IPC分类号： A61N1/39 ,  A61N1/365

CPC分类号： A61N1/3704 ,  A61B5/042 ,  A61B5/046 ,  A61B5/0468 ,  A61B5/6846 ,  A61N1/395

摘要： Device for classifying tachyarrhythmia that obtains pre-defined values, monitors atrial intervals and compares lengths of each interval with pre-defined value IL, stores length of atrial interval if length is shorter than IL, in case X of most recent Y number of atrial intervals have length shorter than IL, evaluates most recent =1 criteria, and controls a cardiac device depending on the classification. Atrial intervals are first evaluated by using the “X-out-of-Y” criterion and subsequently checked for stability after an atrial tachyarrhythmia is detected using “X-out-of-Y” criterion. For stability check, only intervals found shorter than the interval limit are used. Check is based on interval-to-interval comparison rather than as generally practiced, comparisons of individual intervals with the minimum or average of all intervals.

摘要翻译： 用于分类获得预定值的快速性心律失常的装置，监测心房间隔并且将每个间隔的长度与预定义值IL进行比较，如果长度短于IL，则存储心房间隔的长度，在最近的Y个心房间隔的情况下 长度短于IL，评估最近的<= N心房间隔，长度 = 1标准，则将心房快速性心律失常分类为稳定，并根据 分类。 首先通过使用“X-out-Y”标准来评估心房间隔，并随后在使用“X-out-of-Y”标准检测到房性快速性心律失常之后检查其稳定性。 对于稳定性检查，仅使用间隔时间间隔短于间隔限制。 检查是基于间隔间隔比较而不是通常实践的，将各个间隔与所有间隔的最小值或平均值进行比较。

公开(公告)号：US08024031B2

公开(公告)日：2011-09-20

申请号：US12254728

申请日：2008-10-20

申请人： Indra B. Nigam ,  Dirk Muessig ,  Hannes Kraetschmer

发明人： Indra B. Nigam ,  Dirk Muessig ,  Hannes Kraetschmer

IPC分类号： A61B5/04

CPC分类号： A61N1/3704 ,  A61B5/042 ,  A61B5/046 ,  A61B5/0468 ,  A61B5/6846 ,  A61N1/395

摘要： Device for classifying tachyarrhythmia that obtains pre-defined values, monitors atrial intervals and compares lengths of each interval with pre-defined value IL, stores length of atrial interval if length is shorter than IL, in case X of most recent Y number of atrial intervals have length shorter than IL, evaluates most recent =1 criteria, and controls a cardiac device depending on the classification. Atrial intervals are first evaluated by using the “X-out-of-Y” criterion and subsequently checked for stability after an atrial tachyarrhythmia is detected using “X-out-of-Y” criterion. For stability check, only intervals found shorter than the interval limit are used. Check is based on interval-to-interval comparison rather than as generally practiced, comparisons of individual intervals with the minimum or average of all intervals.

摘要翻译： 用于分类获得预定义值的快速性心律失常的装置，监测心房间隔并且将每个间隔的长度与预定义值IL进行比较，如果长度短于IL，则存储心房间隔的长度，在最近的Y个心房间隔的情况下 长度短于IL，评估最近的<= N心房间隔，长度 = 1标准，则将心房快速性心律失常分类为稳定，并根据 分类。 首先通过使用“X-out-Y”标准来评估心房间隔，并随后在使用“X-out-of-Y”标准检测到房性快速性心律失常之后检查其稳定性。 对于稳定性检查，仅使用间隔时间间隔短于间隔限制。 检查是基于间隔间隔比较而不是通常实践的，将各个间隔与所有间隔的最小值或平均值进行比较。

公开(公告)号：US07970462B2

公开(公告)日：2011-06-28

申请号：US11754973

申请日：2007-05-29

申请人： Sharon Lefkov ,  David F. Hastings ,  Christopher S. de Voir ,  Garth Garner ,  Dirk Muessig ,  Hannes Kraetschmer

发明人： Sharon Lefkov ,  David F. Hastings ,  Christopher S. de Voir ,  Garth Garner ,  Dirk Muessig ,  Hannes Kraetschmer

IPC分类号： A61B5/02 ,  A61B5/08 ,  A61B5/05 ,  A61N1/00

CPC分类号： A61B5/053 ,  A61B5/0538 ,  A61B5/0809 ,  A61B5/4878 ,  A61B5/6846 ,  A61B5/7285 ,  A61N1/36521 ,  A61N1/36585

摘要： Implantable medical device with an impedance determination unit with constant current/voltage source having current feed terminals connected to electrodes for intracorporal placement which generates measuring current pulses having constant current/voltage, for causing a current through a body via intracorporally placed electrodes, a measuring unit for measuring voltage/current strength of voltage/current fed through body, an impedance value determination unit connected to the current/voltage source and adapted to determine an impedance value for each measuring current pulse, and an impedance measuring control and evaluation unit connected to the impedance determination unit which controls the unit and evaluates a sequence of consecutive impedance values, the impedance determination unit further adapted to determine at least intrathoracic and intracardiac impedance values for same period of time, the intrathoracic values sampled with a lower sampling rate than the intracardiac values.

摘要翻译： 具有恒定电流/电压源的阻抗确定单元的植入式医疗装置，其具有连接到用于体内放置的电极的电流馈电端子，其产生具有恒定电流/电压的测量电流脉冲，用于通过体内放置的电极使电流通过身体，测量单元 用于测量通过本体馈送的电压/电流的电压/电流强度，阻抗值确定单元，连接到电流/电压源并适于确定每个测量电流脉冲的阻抗值，以及阻抗测量控制和评估单元，连接到 阻抗确定单元，其控制所述单元并评估连续阻抗值的序列，所述阻抗确定单元还适于在相同时间段内至少确定胸内和心内阻抗值，以比心脏内值更低的采样率采样的胸内值 。

公开(公告)号：US20080300504A1

公开(公告)日：2008-12-04

申请号：US11754973

申请日：2007-05-29

申请人： Sharon Lefkov ,  David F. Hastings ,  Christopher S. de Voir ,  Garth Garner ,  Dirk Muessig ,  Hannes Kraetschmer

发明人： Sharon Lefkov ,  David F. Hastings ,  Christopher S. de Voir ,  Garth Garner ,  Dirk Muessig ,  Hannes Kraetschmer

IPC分类号： A61B5/053

CPC分类号： A61B5/053 ,  A61B5/0538 ,  A61B5/0809 ,  A61B5/4878 ,  A61B5/6846 ,  A61B5/7285 ,  A61N1/36521 ,  A61N1/36585

摘要： Implantable medical device with an impedance determination unit with constant current/voltage source having current feed terminals connected to electrodes for intracorporal placement which generates measuring current pulses having constant current/voltage, for causing a current through a body via intracorporally placed electrodes, a measuring unit for measuring voltage/current strength of voltage/current fed through body, an impedance value determination unit connected to the current/voltage source and adapted to determine an impedance value for each measuring current pulse, and an impedance measuring control and evaluation unit connected to the impedance determination unit which controls the unit and evaluates a sequence of consecutive impedance values, the impedance determination unit further adapted to determine at least intrathoracic and intracardiac impedance values for same period of time, the intrathoracic values sampled with a lower sampling rate than the intracardiac values.

摘要翻译： 具有恒定电流/电压源的阻抗确定单元的植入式医疗装置，其具有连接到用于体内放置的电极的电流馈电端子，其产生具有恒定电流/电压的测量电流脉冲，用于通过体内放置的电极使电流通过身体，测量单元 用于测量通过本体馈送的电压/电流的电压/电流强度，阻抗值确定单元，连接到电流/电压源并适于确定每个测量电流脉冲的阻抗值，以及阻抗测量控制和评估单元，连接到 阻抗确定单元，其控制所述单元并评估连续阻抗值的序列，所述阻抗确定单元还适于在相同时间段内至少确定胸内和心内阻抗值，以比心脏内值更低的采样率采样的胸内值 。

公开(公告)号：US08868166B2

公开(公告)日：2014-10-21

申请号：US13455131

申请日：2012-04-25

申请人： Dirk Muessig ,  J. Christopher Moulder ,  Hannes Kraetschmer ,  Jeffrey A. Von Arx ,  Larry Stotts

发明人： Dirk Muessig ,  J. Christopher Moulder ,  Hannes Kraetschmer ,  Jeffrey A. Von Arx ,  Larry Stotts

IPC分类号： A61N5/04 ,  A61B5/00 ,  A61B5/0452 ,  A61N1/05 ,  A61B5/0464 ,  A61B5/046

CPC分类号： A61N1/05 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/721

摘要： Implantable electromedical device or loop recorders or ILRs that solve the problem of very low arrhythmia detection specificities in, i.e., high number of false positives, based on detection and analysis of external noise, specifically muscle noise surrounding the electromedical device. Embodiments generally employ active detection of lead or device movement that induces signal artifacts indicative of external noise. One or more embodiments may detect lead or device movement through use of a piezoelectric transducer, for example located proximally to the device or in the lead of the electromedical.

摘要翻译： 基于外部噪声的检测和分析，特别是电动医疗装置周围的肌肉噪声，可植入的电疗装置或回路记录器或ILR，其解决非常低的心律失常检测特性（即，高数量的假阳性）的问题。 实施例通常采用引导或器件移动的主动检测，其引起指示外部噪声的信号伪影。 一个或多个实施例可以通过使用压电换能器来检测引线或器件的移动，例如位于设备的近侧或电子医疗的引线。

公开(公告)号：US20130079839A1

公开(公告)日：2013-03-28

申请号：US13603418

申请日：2012-09-05

申请人： Jie Lian ,  Volker Lang ,  Hannes Kraetschmer ,  Dirk Muessig

发明人： Jie Lian ,  Volker Lang ,  Hannes Kraetschmer ,  Dirk Muessig

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61B5/0402 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3686

摘要： The present disclosure refers to a heart stimulator comprising a stimulation control unit, a stimulation unit, an impedance measurement unit and an impedance evaluation unit. The stimulation control unit is operatively connected to the stimulation unit to control timing of stimulation pulses by said stimulation unit. The impedance measurement unit is configured to determine an impedance signal reflecting intracardiac impedance. The impedance evaluation unit is operatively connected to the impedance measurement unit and to the stimulation control unit and is configured to evaluate the impedance signal so as to determine an isovolumic contraction time, an isovolumic relaxation time, an ejection time and a filling time from said impedance signal. The stimulation control unit is further configured to control timing of stimulation pulses depending on a performance index.

摘要翻译： 本公开涉及包括刺激控制单元，刺激单元，阻抗测量单元和阻抗评估单元的心脏刺激器。 刺激控制单元可操作地连接到刺激单元以控制所述刺激单元的刺激脉冲的定时。 阻抗测量单元被配置为确定反映心内阻抗的阻抗信号。 阻抗评估单元可操作地连接到阻抗测量单元和刺激控制单元，并被配置为评估阻抗信号，以便确定等容收缩时间，等容弛豫时间，喷射时间和来自所述阻抗的填充时间 信号。 刺激控制单元还被配置为根据性能指标来控制刺激脉冲的定时。

公开(公告)号：US08175709B2

公开(公告)日：2012-05-08

申请号：US11668491

申请日：2007-01-30

申请人： Jie Lian ,  Hannes Kraetschmer ,  Dirk Muessig

发明人： Jie Lian ,  Hannes Kraetschmer ,  Dirk Muessig

IPC分类号： A61N1/362

CPC分类号： A61B5/04017 ,  A61B5/0402 ,  A61B5/04525 ,  A61B5/7232

摘要： A system for heart monitoring comprises an IEGM input for an intracardiac electrocardiogram (IEGM) that is connected to an active filtering stage that is adapted to transform an incoming IEGM into an output ECG signal. The active filtering stage is connected to a filter characterization stage that is adapted to process a recorded, patient specific IEGM template and a corresponding SECG template and to adapt the filter characteristics of said active filtering stage such that the filter characteristics best characterize the input-output relationship between the IEGM template and the corresponding SECG template. As a consequence, the active filtering stage is adapted to transform an incoming IEGM such that the output ECG signal closely resembles a morphology of a corresponding SECG.

摘要翻译： 用于心脏监测的系统包括用于心内心电图（IEGM）的IEGM输入，其连接到适用于将输入的IEGM变换为输出ECG信号的有源滤波级。 有源滤波级连接到滤波器表征阶段，其适于处理记录的，患者特异性IEGM模板和对应的SECG模板，并适应所述有源滤波级的滤波器特性，使得滤波器特性最好地表征输入 - 输出 IEGM模板与相应的SECG模板之间的关系。 因此，有源滤波阶段适于变换输入的IEGM，使得输出的ECG信号非常类似于对应的SECG的形态。

公开(公告)号：US20070288063A1

公开(公告)日：2007-12-13

申请号：US11451138

申请日：2006-06-12

申请人： Christopher S. de Voir ,  Jie Lian ,  Richard A. Schomburg ,  Duane Patterson ,  Hannes Kraetschmer ,  Dirk Muessig

发明人： Christopher S. de Voir ,  Jie Lian ,  Richard A. Schomburg ,  Duane Patterson ,  Hannes Kraetschmer ,  Dirk Muessig

IPC分类号： A61N1/00

CPC分类号： A61N1/3712 ,  A61N1/3622 ,  A61N1/3714

摘要： The invention relates to heart stimulators and implantable atrial pacemakers which utilize a rhythm based atrial capture threshold test wherein in a ventricle based DDI mode a predetermined number of ventricle started atrial and ventricular escape intervals are triggered with an overdrive rate about 20% higher than an intrinsic heart rate. The number of atrial sense events during atrial capture threshold test is counted. Too high of a number of atrial sense events indicates loss of capture due to too small of a pulse strength of the atrial stimulation pulses.

摘要翻译： 本发明涉及心脏刺激器和可植入心房起搏器，其利用基于心律的心房采集阈值测试，其中在基于心室的DDI模式中，预定数量的心室开始心房和心室逃逸间隔被触发，超速率比内在的 心率。 在心房采集阈值测试期间心房感觉事件的数量被计数。 许多心房感觉事件的太高表示由于心房刺激脉冲的脉冲强度太小而导致的捕获损失。