公开(公告)号：US20210085606A1

公开(公告)日：2021-03-25

申请号：US17113785

申请日：2020-12-07

Applicant: Industrial Technology Research Institute

Inventor： Hsin-Hsin SHEN ,  Wen-Shiang CHEN ,  Chueh-Hung WU ,  Ming-Kuan SUN ,  Yu-Chi WANG ,  Sen-Lu CHEN ,  Wei-Lin YU ,  Lih-Tao HSU ,  Shih-Ping LIN

IPC: A61K9/14 ,  A61K9/06 ,  A61K35/16 ,  A61K35/19 ,  A61K38/18 ,  A61K38/38 ,  A61K41/00 ,  A61M37/00 ,  A61K31/704 ,  A61K47/10 ,  A61K47/34 ,  A61L27/00 ,  A61K9/00

Abstract: The disclosure provides a use of hydrogel composition for alleviating degenerative joint and tendon tear. The hydrogel composition includes 100 parts by weight of therapeutic agent and 120-380 parts by weight of biodegradable copolymer, wherein the therapeutic agent comprises platelet-rich plasma (PRP), doxorubicin, transforming growth factor, bovine serum albumin, or a combination thereof. The biodegradable copolymer has a structure of Formula (I) or Formula (II): wherein A is a hydrophilic polyethylene glycol polymer; B is a hydrophobic polyester polymer; BOX is a bifunctional group monomer of 2, 2′-bis(2-oxazoline) used for coupling the blocks A-B or B-A-B; and n is 0 or an integer greater than 0.

公开(公告)号：US20190192437A1

公开(公告)日：2019-06-27

申请号：US15855260

申请日：2017-12-27

Applicant: Industrial Technology Research Institute

Inventor： Hsin-Hsin SHEN ,  Wen-Shiang CHEN ,  Chueh-Hung WU ,  Ming-Kuan SUN ,  Yu-Chi WANG ,  Sen-Lu CHEN ,  Wei-Lin YU ,  Lih-Tao HSU ,  Shih-Ping LIN

IPC: A61K9/14 ,  A61K9/06 ,  A61K35/16 ,  A61K35/19 ,  A61K31/704 ,  A61K38/18 ,  A61K38/38 ,  A61K41/00 ,  A61M37/00

CPC classification number: A61K9/146 ,  A61K9/06 ,  A61K9/145 ,  A61K31/704 ,  A61K35/16 ,  A61K35/19 ,  A61K38/1841 ,  A61K38/385 ,  A61K41/0047 ,  A61M37/0092 ,  A61M2037/0007

Abstract: The disclosure provides a powder form and a hydrogel composition for alleviating degenerative joint and tendon tear. The powder form consists essentially of a 120-380 parts by weight biodegradable copolymer; 15-75 parts by weight urea; and 100 parts by weight platelet-rich plasma; wherein the biodegradable copolymer has a structure of formula (I) or formula (II): wherein A comprises a hydrophilic polyethylene glycol polymer; B comprises a hydrophobic polyester polymer; BOX is bifunctional group monomer of 2, 2′-bis(2-oxazoline) used for coupling the blocks AB or BAB; and n is an integer greater than or equal to 0.