公开(公告)号：US20170106125A1

公开(公告)日：2017-04-20

申请号：US15294047

申请日：2016-10-14

Applicant: Industrial Technology Research Institute

Inventor： Yu-Chi WANG ,  Hsin-Hsin SHEN ,  Chin-Fu CHEN ,  Meng-Yow HSIEH ,  Sen-Lu CHEN ,  Yu-Bing LIOU ,  Tsai-Yu LIN ,  Pei-Shan LI ,  Wei-Lin YU

IPC: A61L31/14 ,  A61L31/04

CPC classification number: A61L31/145 ,  A61L31/041 ,  A61L31/048 ,  A61L31/14 ,  A61L2400/06 ,  C08L29/04

Abstract: The present disclosure provides a hydrogel composition including: a hydrogel having a structure represented by Formula (I) or Formula (II) shown as follows: A-B-BOX-B-A, Formula (I); B-A-B-(BOX-BAB)n-BOX-B-A-B, Formula (II), wherein, A is a hydrophilic polyethylene glycol polymer, B is a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2,2′-Bis(2-oxazoline) for coupling di-block of A-B or tri-block of B-A-B, and n is an integer greater than or equal to 0; and an anti-adhesion additive, wherein the anti-adhesion additive comprises a carbohydrate, a nitrogen-containing cyclic compound, a polymer or a combination thereof.

公开(公告)号：US20210085606A1

公开(公告)日：2021-03-25

申请号：US17113785

申请日：2020-12-07

Applicant: Industrial Technology Research Institute

Inventor： Hsin-Hsin SHEN ,  Wen-Shiang CHEN ,  Chueh-Hung WU ,  Ming-Kuan SUN ,  Yu-Chi WANG ,  Sen-Lu CHEN ,  Wei-Lin YU ,  Lih-Tao HSU ,  Shih-Ping LIN

IPC: A61K9/14 ,  A61K9/06 ,  A61K35/16 ,  A61K35/19 ,  A61K38/18 ,  A61K38/38 ,  A61K41/00 ,  A61M37/00 ,  A61K31/704 ,  A61K47/10 ,  A61K47/34 ,  A61L27/00 ,  A61K9/00

Abstract: The disclosure provides a use of hydrogel composition for alleviating degenerative joint and tendon tear. The hydrogel composition includes 100 parts by weight of therapeutic agent and 120-380 parts by weight of biodegradable copolymer, wherein the therapeutic agent comprises platelet-rich plasma (PRP), doxorubicin, transforming growth factor, bovine serum albumin, or a combination thereof. The biodegradable copolymer has a structure of Formula (I) or Formula (II): wherein A is a hydrophilic polyethylene glycol polymer; B is a hydrophobic polyester polymer; BOX is a bifunctional group monomer of 2, 2′-bis(2-oxazoline) used for coupling the blocks A-B or B-A-B; and n is 0 or an integer greater than 0.

公开(公告)号：US20190192437A1

公开(公告)日：2019-06-27

申请号：US15855260

申请日：2017-12-27

Applicant: Industrial Technology Research Institute

Inventor： Hsin-Hsin SHEN ,  Wen-Shiang CHEN ,  Chueh-Hung WU ,  Ming-Kuan SUN ,  Yu-Chi WANG ,  Sen-Lu CHEN ,  Wei-Lin YU ,  Lih-Tao HSU ,  Shih-Ping LIN

IPC: A61K9/14 ,  A61K9/06 ,  A61K35/16 ,  A61K35/19 ,  A61K31/704 ,  A61K38/18 ,  A61K38/38 ,  A61K41/00 ,  A61M37/00

CPC classification number: A61K9/146 ,  A61K9/06 ,  A61K9/145 ,  A61K31/704 ,  A61K35/16 ,  A61K35/19 ,  A61K38/1841 ,  A61K38/385 ,  A61K41/0047 ,  A61M37/0092 ,  A61M2037/0007

Abstract: The disclosure provides a powder form and a hydrogel composition for alleviating degenerative joint and tendon tear. The powder form consists essentially of a 120-380 parts by weight biodegradable copolymer; 15-75 parts by weight urea; and 100 parts by weight platelet-rich plasma; wherein the biodegradable copolymer has a structure of formula (I) or formula (II): wherein A comprises a hydrophilic polyethylene glycol polymer; B comprises a hydrophobic polyester polymer; BOX is bifunctional group monomer of 2, 2′-bis(2-oxazoline) used for coupling the blocks AB or BAB; and n is an integer greater than or equal to 0.

公开(公告)号：US20200178966A1

公开(公告)日：2020-06-11

申请号：US16225714

申请日：2018-12-19

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Wan-Shiun LOU ,  Yuen-Yung LOH ,  Yung-Lung LIU ,  Wei-Lin YU ,  Yen-Ling WANG ,  Hsin-Hsin SHEN ,  Chia-Hao CHANG

IPC: A61B17/11 ,  A61B17/04 ,  A61B17/122

Abstract: A fixing device for suturing of blood vessels is provided, which includes a connecting rod, a first clamping member, a second clamping member, a first extension tube and a second extension tube. One end of the first clamping member is disposed on the connecting rod, and the other end of the first clamping member has a first clamping head. One end of the second clamping member is disposed on the connecting rod, and the other end of the second clamping member has a second clamping head. The first extension tube is disposed on an inner side of the first clamping head. The second extension tube is disposed on an inner side of the second clamping head and opposite to the first extension tube, wherein a relative position of the first extension tube and the second extension tube is adjustable.