公开(公告)号：US10696638B2

公开(公告)日：2020-06-30

申请号：US16206000

申请日：2018-11-30

Applicant: Industrial Technology Research Institute

Inventor： Chih-Hung Chen ,  Yi-Hsun Chen ,  Jui-Wen Huang ,  Kuo-Kuei Huang ,  Chih-Peng Liu ,  Chrong-Shiong Hwang

IPC: C07D217/02 ,  A61K31/472 ,  A61P27/02 ,  A61K31/4725 ,  A61K9/08 ,  A61K9/00

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof is provided. In formula (I), Ar is indazole, 5-isoquinoline, 6-isoquinoline, or their N-oxide. X is —C(═Z)—, wherein Z is N—CN, NH, NR4, NCOR4, NCONR4R5, NCO-aryl, S, or O. Y and J are independently H, alkyl, aryl, aminoalkyl, —NH2, —CN, —OH, —O-alkyl, —O-aryl, —COOH, —COOR4, —CONHR4, —CONHCH2-aryl, —CONR4CH2-aryl, —NHCOR4, halogen, halogened alkyl, -alkyl-OR4, -alkyl-ONO2, alkyl-ONO2, —OCOOR4, —O(C═O)-aryl, —CHR4OH, —CH2OH, —CH2O(C═O)-aryl, —CH2O(C═O)—R4, —CHR4O(C═O)-aryl, —CHR4O(C═O)—R4, unsaturated carboxylic ester, substituted alkynyl, —NHSO2R4, —SO2R4, —SO2NHR4, or —SO2NR4R5, or Y and J bond together to form a carbocylic or aromatic ring, wherein R4 and R5 are independently H, substituted C1-C6 alkyl, substituted aryl, cycloalkyl, alkylaryl, -alkyl-NR6R7, —S(O)0-2-(alkyl-NR6R7). R1, R2 and R3 are H, C1-C6 alkyl, cycloalkyl, aryl, alkylaryl, alkylheteroaryl, alkylheterocycle, wherein any one thereof is optionally substituted with one or more of OH, NO2, or NR8R9.

公开(公告)号：US09777273B2

公开(公告)日：2017-10-03

申请号：US15322878

申请日：2015-08-05

Applicant: Industrial Technology Research Institute ,  Academia Sinica

Inventor： Yen-Ju Lin ,  Jui-Wen Huang ,  Fu-Tong Liu ,  Huan-Yuan Chen ,  Wei-Chen Hsieh

IPC: C12N15/11 ,  C12N15/113

CPC classification number: C12N15/113 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3521

Abstract: A small interfering RNA is provided. The small interfering RNA consists of a passenger strand and a guide strand, wherein the sequence of the passenger strand comprises the sequence of SEQ ID NO. 7, and the sequence of the guide strand comprises the sequence of SEQ ID NO. 8, wherein the small interfering RNA is capable of inhibiting galectin-12 expression.