公开(公告)号：US11491134B2

公开(公告)日：2022-11-08

申请号：US16731658

申请日：2019-12-31

Applicant: Industrial Technology Research Institute

Inventor： I-Hong Pan ,  Ming-Han Li ,  Kai-An Chuang ,  Shu-Fang Wen

IPC: A61K31/353 ,  A61K9/00 ,  A61P17/06 ,  A61P29/00 ,  A61K9/06

Abstract: A composition for inhibiting skin cell proliferation and/or anti-inflammation is provided. The composition for inhibiting skin cell proliferation and/or anti-inflammation includes: apigenin and luteolin, wherein a weight ratio of the apigenin to the luteolin is about 1.5-25:1, or a mole ratio of the apigenin to the luteolin is about 1.5-25:1. Moreover, the apigenin and the luteolin have a synergistic effect on inhibiting skin cell proliferation and/or anti-inflammation.

公开(公告)号：US10987394B2

公开(公告)日：2021-04-27

申请号：US15852748

申请日：2017-12-22

Applicant: Industrial Technology Research Institute

Inventor： I-Horng Pan ,  Hsin-Jan Yao ,  Chu-Hsun Lu ,  Shu-Fang Wen ,  Po-Yao Hsu ,  Ming-Han Li ,  Kai-An Chuang ,  Chih-Hsuan Chang

IPC: A61K36/28 ,  A61K36/00 ,  A61K36/287 ,  A61K9/00 ,  A61P17/06 ,  A61P17/04

Abstract: The present disclosure provides a method for preparing an extract of Chrysanthemum morifolium with an effect of treating skin diseases, including: (a) performing an extraction procedure on Chrysanthemum morifolium with an extraction solvent to obtain an extract solution; and (b) adding at least one glycoside hydrolases to the extract solution to make an enzyme reaction occur to produce a precipitate, wherein the precipitate is the extract of Chrysanthemum morifolium with an effect of treating skin diseases.