公开(公告)号：US11491134B2

公开(公告)日：2022-11-08

申请号：US16731658

申请日：2019-12-31

Applicant: Industrial Technology Research Institute

Inventor： I-Hong Pan ,  Ming-Han Li ,  Kai-An Chuang ,  Shu-Fang Wen

IPC: A61K31/353 ,  A61K9/00 ,  A61P17/06 ,  A61P29/00 ,  A61K9/06

Abstract: A composition for inhibiting skin cell proliferation and/or anti-inflammation is provided. The composition for inhibiting skin cell proliferation and/or anti-inflammation includes: apigenin and luteolin, wherein a weight ratio of the apigenin to the luteolin is about 1.5-25:1, or a mole ratio of the apigenin to the luteolin is about 1.5-25:1. Moreover, the apigenin and the luteolin have a synergistic effect on inhibiting skin cell proliferation and/or anti-inflammation.

公开(公告)号：US12128082B2

公开(公告)日：2024-10-29

申请号：US17560487

申请日：2021-12-23

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Hsin Jan Yao ,  Yu-Wen Chen ,  Chu-Hsun Lu ,  I-Hong Pan ,  Wen-Yin Chen ,  Tsung-Lin Yang ,  Angela Goh

IPC: A61K36/287 ,  A61P29/00

CPC classification number: A61K36/287 ,  A61P29/00 ,  A61K2236/31 ,  A61K2236/331 ,  A61K2236/333 ,  A61K2236/53 ,  A61K2236/55

Abstract: A method for extracting flavone aglycones in Chrysanthemum morifolium is provided. The method includes: (a) immersing a Chrysanthemum morifolium raw material in water or an aqueous solution to perform an immersion procedure for 3.5 hours or more to obtain an immersion sample; and (b) adding an extraction solvent to the immersion sample to perform an extraction procedure 5-60 minutes to obtain an extract. The Chrysanthemum morifolium raw material includes at least one of the following parts of Chrysanthemum morifolium: whole plant, roots, stems, leaves and flowers.

公开(公告)号：US11701399B2

公开(公告)日：2023-07-18

申请号：US17138610

申请日：2020-12-30

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： I-Hong Pan ,  Kuei-Chang Li ,  Zong-Keng Kuo ,  Chu-Hsun Lu ,  Yen-Wu Hsieh ,  Shu-Fang Wen

IPC: A61K36/074 ,  A61K36/185 ,  A61K36/725 ,  A61P1/00 ,  A61K31/575 ,  A61P25/28 ,  A61P25/20 ,  A61K36/77

CPC classification number: A61K36/074 ,  A61K31/575 ,  A61K36/185 ,  A61K36/725 ,  A61K36/77 ,  A61P1/00 ,  A61P25/20 ,  A61P25/28

Abstract: A composition for modulating intestinal permeability and/or treating and/or preventing leaky gut related diseases including a Chinese herbal compound material or a Chinese herbal compound extract is provided. The Chinese herbal compound material includes Ganoderma, red jujube, longan and lotus seed. Moreover, the Chinese herbal compound extract includes a Ganoderma extract, a red jujube extract, a longan extract and a lotus seed extract.

公开(公告)号：US12226441B2

公开(公告)日：2025-02-18

申请号：US18327583

申请日：2023-06-01

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： I-Hong Pan ,  Kuei-Chang Li ,  Zong-Keng Kuo ,  Chu-Hsun Lu ,  Yen-Wu Hsieh ,  Shu-Fang Wen

IPC: A61K36/074 ,  A61K31/575 ,  A61K36/185 ,  A61K36/725 ,  A61K36/77 ,  A61P1/00 ,  A61P25/20 ,  A61P25/28

Abstract: A composition for inhibiting intestinal permeability, treating leaky gut related diseases and/or preventing leaky gut related diseases including a Chinese herbal compound material or a Chinese herbal compound extract is provided. The Chinese herbal compound material includes Ganoderma, red jujube, longan and lotus seed. Moreover, the Chinese herbal compound extract includes a Ganoderma extract, a red jujube extract, a longan extract and a lotus seed extract.

公开(公告)号：US11083762B2

公开(公告)日：2021-08-10

申请号：US15845394

申请日：2017-12-18

Applicant: Industrial Technology Research Institute

Inventor： I-Hong Pan ,  Wei-Hsuan Hsu ,  Chu-Hsun Lu ,  Shu-Fang Wen ,  Hsin-Chieh Wu

IPC: A61K36/04 ,  A61K35/744 ,  A61K8/9789 ,  A61Q19/08 ,  A61K35/747 ,  A23L33/105 ,  A23L33/00 ,  A61P25/28 ,  A61P25/22 ,  A61P25/24 ,  A61K35/00

Abstract: The present disclosure provides a method for treating and/or alleviating nervous diseases, including: administering an effective amount of a water extract of a plant of Gracilariaceae or a ferment thereof to a subject in need thereof to treat and/or alleviate a nervous disease thereof, wherein the ferment of the water extract of a plant of Gracilariaceae is a lactic acid bacteria ferment.