公开(公告)号：US10821148B2

公开(公告)日：2020-11-03

申请号：US15416391

申请日：2017-01-26

Applicant: Industrial Technology Research Institute

Inventor： Kuo-Kuei Huang ,  I-Horng Pan ,  Ying-Fei Tsai ,  I-Huang Lu ,  Chu-Hsun Lu ,  Shu-Fang Wen ,  Zong-Keng Kuo ,  Shu-Jiau Chiou

IPC: A61K36/00 ,  A61K36/75 ,  A61K31/395 ,  A61K31/366 ,  A61K31/37 ,  A61K31/4015 ,  A61K31/404

Abstract: The present disclosure provides a pharmaceutical composition for treating or alleviating an autoimmune disease and/or complication thereof and/or nephritis, including: an effective amount of an extract of a plant belonging to Rutaceae as an effective ingredient for treating or alleviating the autoimmune disease and/or complication thereof and/or nephritis, wherein the autoimmune disease is selected from a group consisting of lupus erythematosus, psoriasis, psoriatic arthritis, ankylosing spondylitis, rheumatoid arthritis, juvenile idiopathic arthritis, Crohn's disease and ulcerative colitis (UC).

公开(公告)号：US12226441B2

公开(公告)日：2025-02-18

申请号：US18327583

申请日：2023-06-01

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： I-Hong Pan ,  Kuei-Chang Li ,  Zong-Keng Kuo ,  Chu-Hsun Lu ,  Yen-Wu Hsieh ,  Shu-Fang Wen

IPC: A61K36/074 ,  A61K31/575 ,  A61K36/185 ,  A61K36/725 ,  A61K36/77 ,  A61P1/00 ,  A61P25/20 ,  A61P25/28

Abstract: A composition for inhibiting intestinal permeability, treating leaky gut related diseases and/or preventing leaky gut related diseases including a Chinese herbal compound material or a Chinese herbal compound extract is provided. The Chinese herbal compound material includes Ganoderma, red jujube, longan and lotus seed. Moreover, the Chinese herbal compound extract includes a Ganoderma extract, a red jujube extract, a longan extract and a lotus seed extract.

公开(公告)号：US11083762B2

公开(公告)日：2021-08-10

申请号：US15845394

申请日：2017-12-18

Applicant: Industrial Technology Research Institute

Inventor： I-Hong Pan ,  Wei-Hsuan Hsu ,  Chu-Hsun Lu ,  Shu-Fang Wen ,  Hsin-Chieh Wu

IPC: A61K36/04 ,  A61K35/744 ,  A61K8/9789 ,  A61Q19/08 ,  A61K35/747 ,  A23L33/105 ,  A23L33/00 ,  A61P25/28 ,  A61P25/22 ,  A61P25/24 ,  A61K35/00

Abstract: The present disclosure provides a method for treating and/or alleviating nervous diseases, including: administering an effective amount of a water extract of a plant of Gracilariaceae or a ferment thereof to a subject in need thereof to treat and/or alleviate a nervous disease thereof, wherein the ferment of the water extract of a plant of Gracilariaceae is a lactic acid bacteria ferment.

公开(公告)号：US10987394B2

公开(公告)日：2021-04-27

申请号：US15852748

申请日：2017-12-22

Applicant: Industrial Technology Research Institute

Inventor： I-Horng Pan ,  Hsin-Jan Yao ,  Chu-Hsun Lu ,  Shu-Fang Wen ,  Po-Yao Hsu ,  Ming-Han Li ,  Kai-An Chuang ,  Chih-Hsuan Chang

IPC: A61K36/28 ,  A61K36/00 ,  A61K36/287 ,  A61K9/00 ,  A61P17/06 ,  A61P17/04

Abstract: The present disclosure provides a method for preparing an extract of Chrysanthemum morifolium with an effect of treating skin diseases, including: (a) performing an extraction procedure on Chrysanthemum morifolium with an extraction solvent to obtain an extract solution; and (b) adding at least one glycoside hydrolases to the extract solution to make an enzyme reaction occur to produce a precipitate, wherein the precipitate is the extract of Chrysanthemum morifolium with an effect of treating skin diseases.

公开(公告)号：US12128082B2

公开(公告)日：2024-10-29

申请号：US17560487

申请日：2021-12-23

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Hsin Jan Yao ,  Yu-Wen Chen ,  Chu-Hsun Lu ,  I-Hong Pan ,  Wen-Yin Chen ,  Tsung-Lin Yang ,  Angela Goh

IPC: A61K36/287 ,  A61P29/00

CPC classification number: A61K36/287 ,  A61P29/00 ,  A61K2236/31 ,  A61K2236/331 ,  A61K2236/333 ,  A61K2236/53 ,  A61K2236/55

Abstract: A method for extracting flavone aglycones in Chrysanthemum morifolium is provided. The method includes: (a) immersing a Chrysanthemum morifolium raw material in water or an aqueous solution to perform an immersion procedure for 3.5 hours or more to obtain an immersion sample; and (b) adding an extraction solvent to the immersion sample to perform an extraction procedure 5-60 minutes to obtain an extract. The Chrysanthemum morifolium raw material includes at least one of the following parts of Chrysanthemum morifolium: whole plant, roots, stems, leaves and flowers.

公开(公告)号：US11701399B2

公开(公告)日：2023-07-18

申请号：US17138610

申请日：2020-12-30

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： I-Hong Pan ,  Kuei-Chang Li ,  Zong-Keng Kuo ,  Chu-Hsun Lu ,  Yen-Wu Hsieh ,  Shu-Fang Wen

IPC: A61K36/074 ,  A61K36/185 ,  A61K36/725 ,  A61P1/00 ,  A61K31/575 ,  A61P25/28 ,  A61P25/20 ,  A61K36/77

CPC classification number: A61K36/074 ,  A61K31/575 ,  A61K36/185 ,  A61K36/725 ,  A61K36/77 ,  A61P1/00 ,  A61P25/20 ,  A61P25/28

Abstract: A composition for modulating intestinal permeability and/or treating and/or preventing leaky gut related diseases including a Chinese herbal compound material or a Chinese herbal compound extract is provided. The Chinese herbal compound material includes Ganoderma, red jujube, longan and lotus seed. Moreover, the Chinese herbal compound extract includes a Ganoderma extract, a red jujube extract, a longan extract and a lotus seed extract.