公开(公告)号：US11667709B2

公开(公告)日：2023-06-06

申请号：US16948563

申请日：2020-09-23

Applicant: Industrial Technology Research Institute

Inventor： Min-Yuan Chou ,  Li-Tsen Lin ,  Chung-Yuan Sun ,  Ya-Ping Lai ,  Chin-Pen Lai ,  Ssu-Yuan Wu ,  Mei-Wei Lin

IPC: C07K16/28 ,  A61P35/00 ,  A61K45/06

CPC classification number: C07K16/2803 ,  A61P35/00 ,  A61K45/06 ,  C07K2317/565 ,  C07K2317/567

Abstract: Antibodies and antigen-binding fragments that bind to TIGIT are disclosed. The disclosure further relates to methods and compositions for use in treating an immune-related disease (e.g., a cancer or an infection or infectious disease) by administering a composition disclosed herein.

公开(公告)号：US10329350B2

公开(公告)日：2019-06-25

申请号：US13761569

申请日：2013-02-07

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Min-Yuan Chou ,  Chuan-Chuan Huang ,  Hsiu-Chuan Li ,  Ya-Ping Lai

IPC: C07K16/28 ,  C07K16/46 ,  A61K39/00

Abstract: The present invention relates to a method for producing multivalent Fab fragments. In particular, the invention relates to a method for the generation of trimeric Fab fragments by co-expression of a gene construct comprising a heavy chain portion of a Fab fragment and an in-frame fused collagen-like peptide, and a gene construct consisting of a light chain portion of an IgG in mammalian cells. Uses of molecules generated using the method of the invention are also described.