公开(公告)号：US09442120B2

公开(公告)日：2016-09-13

申请号：US13912531

申请日：2013-06-07

Applicant: Industrial Technology Research Institute

Inventor： Tzu-Ling Tseng ,  Ching-Fang Lu ,  Wei-Ya Lin ,  Tsai-Wei Hsu ,  Mary Ya-Ping Yeh ,  Yi-Ting Chen ,  Chwei-Shiun Yang

IPC: G01N33/68 ,  C07K14/705 ,  C07K16/28

CPC classification number: G01N33/6893 ,  C07K14/70503 ,  C07K16/2803 ,  G01N2333/4728 ,  G01N2333/70503 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/56

Abstract: Use of urine biomarkers for diagnosing nephropathy, monitoring nephropathy progress, and assessing efficacy of a nephropathy treatment. These urine biomarkers include leukocyte-associated Ig-like receptor-2, alpha-1 acid glycoprotein, their fragments, and combinations thereof.

公开(公告)号：US20130252267A1

公开(公告)日：2013-09-26

申请号：US13901819

申请日：2013-05-24

Applicant: Industrial Technology Research Institute

Inventor： Wei-Ya Lin ,  Mary Ya-Ping Yeh ,  Tzu-Ling Tseng ,  Ping-Fu Cheng ,  Tsai-Wei Hsu ,  Hung-Yi Li ,  Yi-Ting Chen ,  Yuh-Feng Ling ,  Jin-Shuen Chen ,  Yen-Peng Li

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N2333/4728 ,  G01N2333/52 ,  G01N2333/71 ,  G01N2333/8125 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/56

Abstract: Described are uses of urine and serum biomarkers in diagnosing diabetic nephropathy, staging diabetic nephropathy, monitoring diabetic nephropathy progress, and assessing efficacy of diabetic nephropathy treatments. These biomarkers include urine precursor alpha-2-HS-glycoprotein, urine alpha-1 antitrypsin, urine alpha-1 acid glycoprotein, urine osteopontin, serum osteopontin, their fragments, and combinations thereof.

Abstract translation: 描述了尿和血清生物标志物在诊断糖尿病肾病，分期糖尿病肾病，监测糖尿病肾病进展以及评估糖尿病肾病治疗效果方面的应用。 这些生物标志物包括尿前体α-2-HS-糖蛋白，尿α-1抗胰蛋白酶，尿α-1酸糖蛋白，尿骨桥蛋白，血清骨桥蛋白，其片段及其组合。