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公开(公告)号：US11959101B2
公开(公告)日：2024-04-16
申请号：US17535694
申请日：2021-11-26
Applicant: Industrial Technology Research Institute
Inventor： Ting-Hsuan Chen , Kuo-Hsing Wen , Ya-Hui Chiu , Nien-Tzu Chou , Ching-Fang Lu , Cheng-Tai Chen , Ting-Shuo Chen , Pei-Shin Jiang
Abstract: A cell activation reactor and a cell activation method are provided. The cell activation reactor includes a body, a rotating part, an upper cover, a microporous film, and multiple baffles. The body has an accommodating space, which is suitable for accommodating multiple cells and multiple magnetic beads. The rotating part is disposed in the accommodating space and includes multiple impellers. The microporous film is disposed in the accommodating space and covers multiple holes of the accommodating space. The baffles are disposed in the body. When the rotating part is driven to rotate, the interaction between the baffles and the impellers separates the cells and the magnetic beads.
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Patent Agency Ranking
公开(公告)号：US11555871B2
公开(公告)日：2023-01-17
申请号：US17136001
申请日：2020-12-29
Applicant: Industrial Technology Research Institute
Inventor： Cheng-Tai Chen , Shih-Ya Chen , Yi-Chen Liu , Ching-Fang Lu , Chia-Chen Chang , Erh-Fang Lee
Abstract: A method of detecting a biological sample includes the following steps. A magnetic sensor chip is provided, wherein the magnetic sensor chip includes a substrate and a magnetic sensing layer located on the substrate. Probes are connected to the magnetic sensor chip. A sample solution containing biological samples labeled with a first marker is provided on the magnetic sensor chip, so that the biological samples labeled with the first marker are hybridized with the probes. Magnetic beads labeled with a second marker are provided on the magnetic sensor chip, so that the magnetic beads labeled with the second marker are bound onto the biological samples labeled with the first marker. A signal sensed by the magnetic sensing layer is detected by a magnetic sensor.
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公开(公告)号：US20240311638A1
公开(公告)日：2024-09-19
申请号：US18398161
申请日：2023-12-28
Applicant: Industrial Technology Research Institute
Inventor： Nien-Tzu Chou , Yu-Yu Lin , Ching-Fang Lu , Jian-Hao Li , Ting-Hsuan Chen , Cheng-Tai Chen
IPC: G06N3/0895 , G01N33/50 , G16B40/20
CPC classification number: G06N3/0895 , G01N33/5023 , G16B40/20 , G01N2333/70503 , G01N2333/70596 , G01N2333/7155
Abstract: A method of predicting the efficacy of natural killer cells, including: generating a plurality of training data corresponding to a plurality of donors based on a characteristic factor and a corresponding killing result against the target cancer cells of a plurality of cultured natural killer cells from the donors; obtaining a trained neural network model by inputting the plurality of training data into a neural network model; inputting a to-be-tested input vector corresponding to at least one characteristic factor of a to-be-tested natural killer cell into the trained neural network model to obtain an outputted result vector of the trained neural network model, wherein the result vector indicates a predicted killing result corresponding to the target cancer cell after applying the to-be-tested natural killer cell; and determining a quality of the to-be-tested natural killer cell based on the predicted killing result.
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公开(公告)号：US20220169985A1
公开(公告)日：2022-06-02
申请号：US17535694
申请日：2021-11-26
Applicant: Industrial Technology Research Institute
Inventor： Ting-Hsuan Chen , Kuo-Hsing Wen , Ya-Hui Chiu , Nien-Tzu Chou , Ching-Fang Lu , Cheng-Tai Chen , Ting-Shuo Chen , Pei-Shin Jiang
IPC: C12N5/0783 , C12M1/00 , C12M1/42 , C12M1/06
Abstract: A cell activation reactor and a cell activation method are provided. The cell activation reactor includes a body, a rotating part, an upper cover, a microporous film, and multiple baffles. The body has an accommodating space, which is suitable for accommodating multiple cells and multiple magnetic beads. The rotating part is disposed in the accommodating space and includes multiple impellers. The microporous film is disposed in the accommodating space and covers multiple holes of the accommodating space. The baffles are disposed in the body. When the rotating part is driven to rotate, the interaction between the baffles and the impellers separates the cells and the magnetic beads.
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公开(公告)号：US20210199733A1
公开(公告)日：2021-07-01
申请号：US17136001
申请日：2020-12-29
Applicant: Industrial Technology Research Institute
Inventor： Cheng-Tai Chen , Shih-Ya Chen , Yi-Chen Liu , Ching-Fang Lu , Chia-Chen Chang , Erh-Fang Lee
Abstract: A method of detecting a biological sample includes the following steps. A magnetic sensor chip is provided, wherein the magnetic sensor chip includes a substrate and a magnetic sensing layer located on the substrate. Probes are connected to the magnetic sensor chip. A sample solution containing biological samples labeled with a first marker is provided on the magnetic sensor chip, so that the biological samples labeled with the first marker are hybridized with the probes. Magnetic beads labeled with a second marker are provided on the magnetic sensor chip, so that the magnetic beads labeled with the second marker are bound onto the biological samples labeled with the first marker. A signal sensed by the magnetic sensing layer is detected by a magnetic sensor.
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公开(公告)号：US09442120B2
公开(公告)日：2016-09-13
申请号：US13912531
申请日：2013-06-07
Applicant: Industrial Technology Research Institute
Inventor： Tzu-Ling Tseng , Ching-Fang Lu , Wei-Ya Lin , Tsai-Wei Hsu , Mary Ya-Ping Yeh , Yi-Ting Chen , Chwei-Shiun Yang
IPC: G01N33/68 , C07K14/705 , C07K16/28
CPC classification number: G01N33/6893 , C07K14/70503 , C07K16/2803 , G01N2333/4728 , G01N2333/70503 , G01N2800/347 , G01N2800/52 , G01N2800/56
Abstract: Use of urine biomarkers for diagnosing nephropathy, monitoring nephropathy progress, and assessing efficacy of a nephropathy treatment. These urine biomarkers include leukocyte-associated Ig-like receptor-2, alpha-1 acid glycoprotein, their fragments, and combinations thereof.
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