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公开(公告)号：US08975013B2
公开(公告)日：2015-03-10
申请号：US14018608
申请日：2013-09-05
Applicant: Ineos Bio SA
Inventor： David Scott Snyder
CPC classification number: C12Q1/04 , C12P7/065 , C12P7/08 , C12Q3/00 , G01N21/31 , G01N33/84 , Y02E50/17
Abstract: A process for controlling concentration of CO in a bioreactor provides a direct and real time measurement of dissolved CO in a fermentation medium. The process for controlling concentrations of CO in a bioreactor includes contacting an aliquot of fermentation medium with at least one CO binding ligand and at least one microbial inactivator.
Abstract translation: 用于控制生物反应器中CO浓度的方法提供了发酵培养基中溶解的CO的直接和实时测量。 用于控制生物反应器中CO浓度的方法包括将等分试样的发酵培养基与至少一种CO结合配体和至少一种微生物灭活剂接触。
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Patent Agency Ranking
公开(公告)号：US09593357B2
公开(公告)日：2017-03-14
申请号：US14612528
申请日：2015-02-03
Applicant: INEOS BIO SA
Inventor： David Scott Snyder
CPC classification number: C12Q1/04 , C12P7/065 , C12P7/08 , C12Q3/00 , G01N21/31 , G01N33/84 , Y02E50/17
Abstract: A process for controlling concentration of CO in a bioreactor provides a direct and real time measurement of dissolved CO in a fermentation medium. The process for controlling concentrations of CO in a bioreactor includes contacting an aliquot of fermentation medium with at least one CO binding ligand and at least one microbial inactivator.
Abstract translation: 用于控制生物反应器中CO浓度的方法提供了发酵培养基中溶解的CO的直接和实时测量。 用于控制生物反应器中CO浓度的方法包括将等分试样的发酵培养基与至少一种CO结合配体和至少一种微生物灭活剂接触。
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公开(公告)号：US20140080117A1
公开(公告)日：2014-03-20
申请号：US14018670
申请日：2013-09-05
Applicant: INEOS BIO SA
Inventor： David Scott Snyder
IPC: C12Q3/00
CPC classification number: C12Q1/04 , C12P7/065 , C12P7/08 , C12Q3/00 , G01N21/31 , G01N33/84 , Y02E50/17
Abstract: A process is provided for fermenting CO-containing gaseous substrates. The process is effective for decreasing lag times and maintaining a culture in steady state by controlling CO concentration and minimizing effects of high or low CO concentrations during fermentation. The process includes providing syngas to a first fermentation zone, fermenting the syngas, and determining a CO concentration in a fermentation medium in the first fermentation zone. If the CO concentration in fermentation medium in the first fermentation zone has a value of about 0.12 μM or greater, then at least a portion of the syngas being provided to the first fermentation zone is provided to one or more subsequent fermentation zones in an amount effective for providing a CO concentration in any subsequent fermentation zone of about 0.12 μM or less.
Abstract translation: 提供了一种用于发酵含CO气体底物的方法。 该方法通过控制CO浓度和最小化发酵过程中高浓度或低CO浓度的影响，有效减少滞后时间并保持培养状态。 该方法包括向第一发酵区提供合成气，发酵合成气，以及确定第一发酵区中发酵培养基中的CO浓度。 如果第一发酵区的发酵培养基中的CO浓度具有约0.12μM或更大的值，则将提供给第一发酵区的合成气的至少一部分提供给一个或多个后续发酵区，其量有效 用于在约0.12μM或更少的任何后续发酵区域中提供CO浓度。
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公开(公告)号：US20150152464A1
公开(公告)日：2015-06-04
申请号：US14612528
申请日：2015-02-03
Applicant: INEOS BIO SA
Inventor： David Scott Snyder
IPC: C12Q1/04
CPC classification number: C12Q1/04 , C12P7/065 , C12P7/08 , C12Q3/00 , G01N21/31 , G01N33/84 , Y02E50/17
Abstract: A process for controlling concentration of CO in a bioreactor provides a direct and real time measurement of dissolved CO in a fermentation medium. The process for controlling concentrations of CO in a bioreactor includes contacting an aliquot of fermentation medium with at least one CO binding ligand and at least one microbial inactivator.
Abstract translation: 用于控制生物反应器中CO浓度的方法提供了发酵培养基中溶解的CO的直接和实时测量。 用于控制生物反应器中CO浓度的方法包括将等分试样的发酵培养基与至少一种CO结合配体和至少一种微生物灭活剂接触。
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公开(公告)号：US08980576B2
公开(公告)日：2015-03-17
申请号：US14018670
申请日：2013-09-05
Applicant: Ineos Bio SA
Inventor： David Scott Snyder
CPC classification number: C12Q1/04 , C12P7/065 , C12P7/08 , C12Q3/00 , G01N21/31 , G01N33/84 , Y02E50/17
Abstract: A process is provided for fermenting CO-containing gaseous substrates. The process is effective for decreasing lag times and maintaining a culture in steady state by controlling CO concentration and minimizing effects of high or low CO concentrations during fermentation. The process includes providing syngas to a first fermentation zone, fermenting the syngas, and determining a CO concentration in a fermentation medium in the first fermentation zone. If the CO concentration in fermentation medium in the first fermentation zone has a value of about 0.12 μM or greater, then at least a portion of the syngas being provided to the first fermentation zone is provided to one or more subsequent fermentation zones in an amount effective for providing a CO concentration in any subsequent fermentation zone of about 0.12 μM or less.
Abstract translation: 提供了一种用于发酵含CO气体底物的方法。 该方法通过控制CO浓度和最小化发酵过程中高浓度或低CO浓度的影响，有效减少滞后时间并保持培养状态。 该方法包括向第一发酵区提供合成气，发酵合成气，以及确定第一发酵区中发酵培养基中的CO浓度。 如果第一发酵区的发酵培养基中的CO浓度具有约0.12μM或更大的值，则将提供给第一发酵区的合成气的至少一部分提供给一个或多个后续发酵区，其量有效 用于在约0.12μM或更少的任何后续发酵区域中提供CO浓度。
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公开(公告)号：US20140080116A1
公开(公告)日：2014-03-20
申请号：US14018608
申请日：2013-09-05
Applicant: INEOS BIO SA
Inventor： David Scott Snyder
CPC classification number: C12Q1/04 , C12P7/065 , C12P7/08 , C12Q3/00 , G01N21/31 , G01N33/84 , Y02E50/17
Abstract: A process for controlling concentration of CO in a bioreactor provides a direct and real time measurement of dissolved CO in a fermentation medium. The process for controlling concentrations of CO in a bioreactor includes contacting an aliquot of fermentation medium with at least one CO binding ligand and at least one microbial inactivator.
Abstract translation: 用于控制生物反应器中CO浓度的方法提供了发酵培养基中溶解的CO的直接和实时测量。 用于控制生物反应器中CO浓度的方法包括将等分试样的发酵培养基与至少一种CO结合配体和至少一种微生物灭活剂接触。
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