公开(公告)号：US09907845B2

公开(公告)日：2018-03-06

申请号：US14096582

申请日：2013-12-04

申请人： Infectious Disease Research Institute

发明人： Steven G. Reed ,  Darrick Carter

IPC分类号： A61K39/395 ,  A61K39/39 ,  A61K9/107 ,  A61K39/00 ,  A61K39/35 ,  A61K45/06 ,  A61K39/008 ,  A61K39/04 ,  A61K39/145

CPC分类号： A61K39/39 ,  A61K9/107 ,  A61K39/0011 ,  A61K39/008 ,  A61K39/04 ,  A61K39/145 ,  A61K39/35 ,  A61K45/06 ,  A61K2039/55511 ,  A61K2039/55572 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/396 ,  Y02A50/41 ,  Y02A50/491

摘要： Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.

公开(公告)号：US09987355B2

公开(公告)日：2018-06-05

申请号：US13930953

申请日：2013-06-28

申请人： Infectious Disease Research Institute

发明人： Steven G. Reed ,  Darrick Carter

IPC分类号： A61K39/39 ,  A61K9/107 ,  A61K39/00 ,  A61K39/35 ,  A61K45/06 ,  A61K39/008 ,  A61K39/04 ,  A61K39/145

CPC分类号： A61K39/39 ,  A61K9/107 ,  A61K39/0011 ,  A61K39/008 ,  A61K39/04 ,  A61K39/145 ,  A61K39/35 ,  A61K45/06 ,  A61K2039/55511 ,  A61K2039/55572 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/396 ,  Y02A50/41 ,  Y02A50/491

摘要： Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.

公开(公告)号：US11266602B2

公开(公告)日：2022-03-08

申请号：US16098619

申请日：2017-05-15

申请人： Infectious Disease Research Institute ,  University of Virginia Patent Foundation

发明人： Christopher B. Fox ,  Susan S. Lin ,  Darrick Carter ,  Neal Van Hoeven ,  Mayuresh M. Abhyankar ,  William A. Petri

IPC分类号： A61K9/127 ,  A61K31/739 ,  A61K39/39 ,  A61K39/00

摘要： Provided herein are PEGylated liposomes, and methods of making and using thereof. The PEGylated liposomes comprise at least a cholesterol, a non-PEGylated neutral lipid, and a PEGylated lipid, wherein the average molecular weight of the PEG component in the PEGylated lipid is about 5000 Daltons or less. The PEGylated liposomes are stable and capable of delivery of an agent for the generation of an immune response, for example an agent for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the PEGylated liposomes and using the PEGylated liposomes for stimulating an immune response are also provided.

公开(公告)号：US20210069323A1

公开(公告)日：2021-03-11

申请号：US16855622

申请日：2020-04-22

申请人： Infectious Disease Research Institute

发明人： Steven G. Reed ,  Darrick Carter

IPC分类号： A61K39/39 ,  A61K9/107 ,  A61K39/00 ,  A61K39/35 ,  A61K45/06 ,  A61K39/008 ,  A61K39/04 ,  A61K39/145

摘要： Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.

公开(公告)号：US20160058860A1

公开(公告)日：2016-03-03

申请号：US14849212

申请日：2015-09-09

申请人： Infectious Disease Research Institute

发明人： Steven G. Reed ,  Darrick Carter

IPC分类号： A61K39/39 ,  A61K39/008 ,  A61K45/06 ,  A61K39/00 ,  C12N7/00 ,  A61K39/145 ,  A61K39/04

CPC分类号： A61K39/39 ,  A61K39/0005 ,  A61K39/008 ,  A61K39/04 ,  A61K39/145 ,  A61K45/06 ,  A61K2039/53 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/57 ,  C12N7/00 ,  C12N2760/16034 ,  C12N2760/16071 ,  Y02A50/41 ,  Y02A50/412

摘要： Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.

公开(公告)号：US20150335736A1

公开(公告)日：2015-11-26

申请号：US14581062

申请日：2014-12-23

申请人： Infectious Disease Research Institute

发明人： Steven G. Reed ,  Darrick Carter

IPC分类号： A61K39/39 ,  A61K39/04 ,  A61K39/008 ,  A61K9/107 ,  A61K39/145

CPC分类号： A61K39/39 ,  A61K9/107 ,  A61K39/0011 ,  A61K39/008 ,  A61K39/04 ,  A61K39/145 ,  A61K39/35 ,  A61K45/06 ,  A61K2039/55511 ,  A61K2039/55572 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/396 ,  Y02A50/41 ,  Y02A50/491

摘要： Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.

摘要翻译： 基于在基本上均匀形式提供的合成的吡喃葡萄糖基脂质佐剂（GLA）中发现有用的免疫佐剂性质，公开了组合物和方法，包括用于诱导或增强免疫应答的疫苗和药物组合物。 在化学上，合成的GLA提供了从批次到批次的一致的疫苗组分，而不会损害天然产物佐剂的污染物或活性的波动。 还提供了疫苗和药物组合物，其包括GLA和抗原，Toll样受体（TLR）激动剂，辅助佐剂和载体如药物载体中的一种或多种。

公开(公告)号：US20140341970A1

公开(公告)日：2014-11-20

申请号：US14096582

申请日：2013-12-04

申请人： Infectious Disease Research Institute

发明人： Steven G. Reed ,  Darrick Carter

IPC分类号： A61K39/39 ,  A61K39/008 ,  A61K39/04 ,  A61K39/145

CPC分类号： A61K39/39 ,  A61K9/107 ,  A61K39/0011 ,  A61K39/008 ,  A61K39/04 ,  A61K39/145 ,  A61K39/35 ,  A61K45/06 ,  A61K2039/55511 ,  A61K2039/55572 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/396 ,  Y02A50/41 ,  Y02A50/491

摘要： Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.

摘要翻译： 基于在基本上均匀形式提供的合成的吡喃葡萄糖基脂质佐剂（GLA）中发现有用的免疫佐剂性质，公开了组合物和方法，包括用于诱导或增强免疫应答的疫苗和药物组合物。 在化学上，合成的GLA提供了从批次到批次的一致的疫苗组分，而不会损害天然产物佐剂的污染物或活性的波动。 还提供了疫苗和药物组合物，其包括GLA和抗原，Toll样受体（TLR）激动剂，辅助佐剂和载体如药物载体中的一种或多种。

公开(公告)号：US20220160632A1

公开(公告)日：2022-05-26

申请号：US17560594

申请日：2021-12-23

申请人： Infectious Disease Research Institute ,  University of Virginia Patent Foundation

发明人： Christopher B. Fox ,  Susan S. Lin ,  Darrick Carter ,  Neal Van Hoeven ,  Mayuresh M. Abhyankar ,  William A. Petri

IPC分类号： A61K9/127 ,  A61K31/739 ,  A61K39/39

摘要： Provided herein are PEGylated liposomes, and methods of making and using thereof. The PEGylated liposomes comprise at least a cholesterol, a non-PEGylated neutral lipid, and a PEGylated lipid, wherein the average molecular weight of the PEG component in the PEGylated lipid is about 5000 Daltons or less. The PEGylated liposomes are stable and capable of delivery of an agent for the generation of an immune response, for example an agent for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the PEGylated liposomes and using the PEGylated liposomes for stimulating an immune response are also provided.

公开(公告)号：US10765736B2

公开(公告)日：2020-09-08

申请号：US15823852

申请日：2017-11-28

申请人： Infectious Disease Research Institute

发明人： Steven G. Reed ,  Darrick Carter

IPC分类号： A61K39/395 ,  A61K39/39 ,  A61K9/107 ,  A61K39/00 ,  A61K39/35 ,  A61K45/06 ,  A61K39/008 ,  A61K39/04 ,  A61K39/145

摘要： Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.

公开(公告)号：US20180236063A1

公开(公告)日：2018-08-23

申请号：US15875517

申请日：2018-01-19

申请人： Infectious Disease Research Institute

发明人： Steven G. Reed ,  Darrick Carter

IPC分类号： A61K39/39 ,  A61K39/008 ,  A61K39/145 ,  A61K39/00 ,  A61K39/04 ,  A61K39/35 ,  A61K9/107 ,  A61K45/06

摘要： Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glycopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.