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16 条记录 (耗时 0.04 秒)

    Aβ immunogenic peptide carrier conjugates and methods of producing same
    4.
    发明授权
    Aβ immunogenic peptide carrier conjugates and methods of producing same 有权
    A＆bgr 免疫原性肽载体缀合物及其生产方法

    公开(公告)号：US09095536B2

    公开(公告)日：2015-08-04

    申请号：US11841919

    申请日：2007-08-20

    申请人： Rasappa G. Arumugham ,  A. Krishna Prasad ,  Michael Hagen

    发明人： Rasappa G. Arumugham ,  A. Krishna Prasad ,  Michael Hagen

    IPC分类号： A61K38/04 ,  C07K7/06 ,  C07K17/00 ,  G01N33/532 ,  A61K39/00 ,  A61K47/48

    CPC分类号： A61K39/0007 ,  A61K47/643 ,  A61K47/646 ,  A61K2039/6031 ,  A61K2039/6081 ,  A61K2039/62 ,  Y02A50/412

    摘要： The present invention is directed to methods of producing conjugates of Aβ peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and wherein any unconjugated reactive functional groups on amino acid residues are inactivated via capping, thus retaining the immunological functionality of the carrier molecule, but reducing the propensity for undesirable reactions that could render the conjugate less safe or effective. Furthermore, the invention also relates to such immunogenic products and immunogenic compositions containing such immunogenic products made by such methods.

    摘要翻译： 本发明涉及生产A和Bgr的缀合物的方法; 具有蛋白质/多肽载体分子的肽免疫原，其可用作免疫原，其中肽免疫原通过载体或任选连接的接头分子的氨基酸残基上的活化官能团与蛋白载体缀合，并且其中任何未缀合的反应性官能团在 氨基酸残基通过封端失活，因此保留了载体分子的免疫功能，但降低了可能使缀合物更不安全或有效的不良反应的倾向。 此外，本发明还涉及这样的免疫原性产物和含有由这些方法制备的免疫原性产物的免疫原性组合物。

    A-β immunogenic peptide carrier conjugates and methods of producing same
    5.
    发明授权
    A-β immunogenic peptide carrier conjugates and methods of producing same 有权
    A-＆bgr 免疫原性肽载体缀合物及其生产方法

    公开(公告)号：US08227403B2

    公开(公告)日：2012-07-24

    申请号：US10583503

    申请日：2004-12-17

    申请人： Rasappa G. Arumugham ,  A. Krishna Prasad ,  Michael Hagen

    发明人： Rasappa G. Arumugham ,  A. Krishna Prasad ,  Michael Hagen

    IPC分类号： A61K38/00 ,  C07K17/00

    CPC分类号： A61K39/0007 ,  A61K47/643 ,  A61K47/646 ,  A61K2039/6031 ,  A61K2039/6081 ,  A61K2039/62 ,  Y02A50/412

    摘要： The present invention is directed to methods of producing conjugates of Aβ peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and wherein any unconjugated reactive functional groups on amino acid residues are inactivated via capping, thus retaining the immunological functionality of the carrier molecule, but reducing the propensity for undesirable reactions that could render the conjugate less safe or effective. Furthermore, the invention also relates to such immunogenic products and immunogenic compositions containing such immunogenic products made by such methods.

    摘要翻译： 本发明涉及生产A和Bgr的缀合物的方法; 具有蛋白质/多肽载体分子的肽免疫原，其可用作免疫原，其中肽免疫原通过载体或任选连接的接头分子的氨基酸残基上的活化官能团与蛋白载体缀合，并且其中任何未缀合的反应性官能团在 氨基酸残基通过封端失活，因此保留了载体分子的免疫功能，但降低了可能使缀合物更不安全或有效的不良反应的倾向。 此外，本发明还涉及这样的免疫原性产物和含有由这些方法制备的免疫原性产物的免疫原性组合物。

    Three-dimensional correlated data display
    6.
    发明申请
    Three-dimensional correlated data display 失效
    三维相关数据显示

    公开(公告)号：US20050234670A1

    公开(公告)日：2005-10-20

    申请号：US10828936

    申请日：2004-04-20

    申请人： Michael Hagen ,  Wendell Damm

    发明人： Michael Hagen ,  Wendell Damm

    IPC分类号： G01R13/20 ,  G01R13/34 ,  G06F19/00 ,  G06T11/20

    CPC分类号： G06T11/206 ,  G01R13/206 ,  G01R13/345

    摘要： A method and apparatus for synchronizing presentation of multi-domain measurements using actual or quasi 3-D representation. The synchronization between data streams acquired in different measurement domains is performed by using timestamps, a common trigger event, or a common clock, or a combination of any or all of them. In this way, for example, a transient anomaly in the RF spectrum of a communications signal may be correlated with, and displayed with, a related corrupted data communications packet.

    摘要翻译： 一种用于使用实际或准3-D表示同步呈现多域测量的方法和装置。 在不同测量域中获取的数据流之间的同步通过使用时间戳，公共触发事件或公共时钟，或其中任何一个或全部的组合来执行。 以这种方式，例如，通信信号的RF频谱中的瞬态异常可以与相关的损坏的数据通信分组相关联并且与相关的损坏的数据通信分组一起显示。

    A-β immunogenic peptide carrier conjugates and methods of producing same
    7.
    发明授权
    A-β immunogenic peptide carrier conjugates and methods of producing same 有权
    A-＆bgr 免疫原性肽载体缀合物及其生产方法

    公开(公告)号：US09125847B2

    公开(公告)日：2015-09-08

    申请号：US13396543

    申请日：2012-02-14

    申请人： Rasappa G. Arumugham ,  A. Krishna Prasad ,  Michael Hagen

    发明人： Rasappa G. Arumugham ,  A. Krishna Prasad ,  Michael Hagen

    IPC分类号： A61K38/04 ,  C07K7/06 ,  C07K17/00 ,  G01N33/532 ,  A61K39/00 ,  A61K47/48

    CPC分类号： A61K39/0007 ,  A61K47/643 ,  A61K47/646 ,  A61K2039/6031 ,  A61K2039/6081 ,  A61K2039/62 ,  Y02A50/412

    摘要： The present invention is directed to methods of producing conjugates of Aβ peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and wherein any unconjugated reactive functional groups on amino acid residues are inactivated via capping, thus retaining the immunological functionality of the carrier molecule, but reducing the propensity for undesirable reactions that could render the conjugate less safe or effective. Furthermore, the invention also relates to such immunogenic products and immunogenic compositions containing such immunogenic products made by such methods.

    摘要翻译： 本发明涉及生产A和Bgr的缀合物的方法; 具有蛋白质/多肽载体分子的肽免疫原，其可用作免疫原，其中肽免疫原通过载体或任选连接的接头分子的氨基酸残基上的活化官能团与蛋白载体缀合，并且其中任何未缀合的反应性官能团在 氨基酸残基通过封端失活，因此保留了载体分子的免疫功能，但降低了可能使缀合物更不安全或有效的不良反应的倾向。 此外，本发明还涉及这样的免疫原性产物和含有由这些方法制备的免疫原性产物的免疫原性组合物。