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公开(公告)号：US20220348682A1
公开(公告)日：2022-11-03
申请号：US17270571
申请日：2019-08-29
发明人： Lei Xiao , He Sun , Zhiyuan Cao , Wensheng Wang , Chengfei Pu , Li Mao
IPC分类号： C07K16/30 , C07K14/725 , A61K47/68
摘要： The compositions and methods described herein are directed to treating solid tumor using CAR T therapy. The compositions include CAR comprising an extracellular domain that binds a siglec protein or a receptor that binds the peptide hormone kisspeptin.
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公开(公告)号：US20210230308A1
公开(公告)日：2021-07-29
申请号：US17220387
申请日：2021-04-01
发明人： Lei Xiao , He Sun , Zhiyuan Cao , Wensheng Wang , Chengfei Pu , Li Mao
摘要： The compositions and methods described herein are directed to treating solid tumor using CAR T therapy. The compositions include CAR comprising an extracellular domain that binds a siglec protein or a receptor that binds the peptide hormone kisspeptin.
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公开(公告)号：US11161913B2
公开(公告)日：2021-11-02
申请号：US17220387
申请日：2021-04-01
发明人： Lei Xiao , He Sun , Zhiyuan Cao , Wensheng Wang , Chengfei Pu , Li Mao
摘要： The compositions and methods described herein are directed to treating solid tumor using CAR T therapy. The compositions include CAR comprising an extracellular domain that binds a siglec protein or a receptor that binds the peptide hormone kisspeptin.
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公开(公告)号：US11773384B2
公开(公告)日：2023-10-03
申请号：US17233935
申请日：2021-04-19
CPC分类号： C12N9/22 , A61K35/17 , A61P35/00 , C12N9/10 , C12N15/52 , C12N15/625 , C12Y301/21 , C07K2319/81
摘要： The present disclosure relates to compositions and methods for compositions, methods, and kits for treating cancer using modified T cells in which TRAC genes are inactivated using a Zinc-finger nuclease (ZFN). The ZFN may include a first zinc finger protein (ZFP) that binds a first target site in a T-cell receptor alpha constant (TRAC) gene and a second ZFP that binds a second target site in the TRAC gene.
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公开(公告)号：US20210238568A1
公开(公告)日：2021-08-05
申请号：US17233935
申请日：2021-04-19
摘要： The present disclosure relates to compositions and methods for compositions, methods, and kits for treating cancer using modified T cells in which TRAC genes are inactivated using a Zinc-finger nuclease (ZFN). The ZFN may include a first zinc finger protein (ZFP) that binds a first target site in a T-cell receptor alpha constant (TRAC) gene and a second ZFP that binds a second target site in the TRAC gene.
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公开(公告)号：US11008556B2
公开(公告)日：2021-05-18
申请号：US16157545
申请日：2018-10-11
摘要： The present disclosure relates to compositions and methods for compositions, methods, and kits for treating cancer using modified T cells in which TRAC genes are inactivated using a Zinc-finger nuclease (ZFN). The ZFN may include a first zinc finger protein (ZFP) that binds a first target site in a T-cell receptor alpha constant (TRAC) gene and a second ZFP that binds a second target site in the TRAC gene.
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公开(公告)号：US20220265708A1
公开(公告)日：2022-08-25
申请号：US16961418
申请日：2019-01-10
发明人： Lei Xiao , Chengfei Pu , Zhiyuan Cao , Zhao Wu , Li Mao , Mao Bi
IPC分类号： A61K35/17 , C12N5/0783 , C12N15/62 , C12N15/86
摘要： The present disclosure relates to compositions and methods for enhancing T cell response and/or CAR cell expansion in vivo and/or in vitro. For example, a cell may comprise a first chimeric antigen receptor (CAR) and a second CAR, wherein a binding domain of the first CAR binds a first antigen, and a binding domain of the second CAR binds a second antigen. The first antigen is different from the second antigen. In embodiments, the first CAR may recognize a surface molecule of a blood cell.
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