公开(公告)号：US10203297B2

公开(公告)日：2019-02-12

申请号：US14879948

申请日：2015-10-09

Applicant: INTEL CORPORATION

Inventor： Jonathan S. Daniels ,  Oguz H. Elibol ,  Grace M. Credo ,  Xing Su

IPC: G01N27/327 ,  C12Q1/68 ,  G01R27/26 ,  G01N27/22 ,  G01K7/34 ,  G06K7/08 ,  G01D5/24 ,  G01L1/14 ,  B82Y30/00

Abstract: Described herein is a device comprising a plurality of first reaction electrodes arranged in an array, the plurality of first reaction electrodes configured to be exposed to a solution and having a capacitance; first circuitry configured to controllably connect the plurality of first reaction electrodes to a bias source and controllably disconnect the plurality of first reaction electrodes from the bias source; and second circuitry configured to measure a rate of charging or discharging of the capacitance. Also described herein is a method of using this device to sequence DNA.

公开(公告)号：US09222908B2

公开(公告)日：2015-12-29

申请号：US13839564

申请日：2013-03-15

Applicant: Intel Corporation

Inventor： Jonathan S. Daniels ,  Oguz H. Elibol ,  Grace M. Credo ,  Xing Su

IPC: G01N27/30 ,  B82Y30/00 ,  G01N27/327

CPC classification number: G01N27/30 ,  B82Y30/00 ,  G01N27/3277 ,  Y10S977/734 ,  Y10S977/742

Abstract: Described herein is a device comprising: a plurality of first reaction electrodes arranged in an array, the plurality of first reaction electrodes configured to be exposed to a fluid and having a capacitance; first circuitry configured to controllably set the plurality of first reaction electrode to a predetermined voltage and allow the capacitance of the plurality of first reaction electrode to charge or discharge through the fluid; and second circuitry configured to measure a rate of charging or discharging of the capacitance of the plurality of first reaction electrodes. Also described herein is a method of using this device to sequence DNA.

Abstract translation: 本文描述的是一种装置，包括：多个以阵列排列的第一反应电极，多个第一反应电极构造成暴露于流体并具有电容; 第一电路，被配置为可控地将所述多个第一反应电极设置为预定电压，并允许所述多个第一反应电极的电容通过所述流体进行充电或放电; 以及第二电路，被配置为测量所述多个第一反应电极的电容的充电或放电速率。 本文还描述了使用该装置来对DNA进行序列化的方法。