DEVICE FOR SINGLE MOLECULE DETECTION AND FABRICATION METHODS THEREOF
    2.
    发明申请
    DEVICE FOR SINGLE MOLECULE DETECTION AND FABRICATION METHODS THEREOF 审中-公开
    用于单分子检测的装置及其制造方法

    公开(公告)号:US20160187282A1

    公开(公告)日:2016-06-30

    申请号:US14583373

    申请日:2014-12-26

    申请人: INTEL CORPORATION

    摘要: Disclosed herein is a device comprising an electrode pair comprising a first electrode and a second electrode; a nanogap channel; wherein a portion of the nanogap channel is sandwiched between the first electrode and the second electrode; wherein at least a portion of the first electrode directly faces at least a portion of the second electrode, across the nanogap channel; wherein the portion of the first electrode and the portion of the second electrode are exposed to an interior of the nanogap channel; and wherein the first electrode or the second electrode comprises doped diamond, silicon carbide or a combination thereof. Also disclosed herein is a method comprising forming on a carrier substrate a first material layer comprising doped diamond, silicon carbide or a combination thereof; bonding the first material layer onto an electrical circuit.

    摘要翻译: 本文公开了一种包括电极对的装置,包括第一电极和第二电极; 纳米沟渠 其中所述纳米槽通道的一部分夹在所述第一电极和所述第二电极之间; 其中所述第一电极的至少一部分直接面对所述第二电极的至少一部分,穿过所述纳米槽通道; 其中所述第一电极的所述部分和所述第二电极的所述部分暴露于所述纳米隙通道的内部; 并且其中所述第一电极或所述第二电极包括掺杂的金刚石,碳化硅或其组合。 本文还公开了一种方法,包括在载体衬底上形成包含掺杂金刚石,碳化硅或其组合的第一材料层; 将第一材料层接合到电路上。

    Device and method for detecting redox reactions in solution
    6.
    发明授权
    Device and method for detecting redox reactions in solution 有权
    用于检测溶液中氧化还原反应的装置和方法

    公开(公告)号:US09222908B2

    公开(公告)日:2015-12-29

    申请号:US13839564

    申请日:2013-03-15

    申请人: Intel Corporation

    摘要: Described herein is a device comprising: a plurality of first reaction electrodes arranged in an array, the plurality of first reaction electrodes configured to be exposed to a fluid and having a capacitance; first circuitry configured to controllably set the plurality of first reaction electrode to a predetermined voltage and allow the capacitance of the plurality of first reaction electrode to charge or discharge through the fluid; and second circuitry configured to measure a rate of charging or discharging of the capacitance of the plurality of first reaction electrodes. Also described herein is a method of using this device to sequence DNA.

    摘要翻译: 本文描述的是一种装置,包括:多个以阵列排列的第一反应电极,多个第一反应电极构造成暴露于流体并具有电容; 第一电路,被配置为可控地将所述多个第一反应电极设置为预定电压,并允许所述多个第一反应电极的电容通过所述流体进行充电或放电; 以及第二电路,被配置为测量所述多个第一反应电极的电容的充电或放电速率。 本文还描述了使用该装置来对DNA进行序列化的方法。

    SINGLE MOLECULE DETECTION
    10.
    发明申请
    SINGLE MOLECULE DETECTION 审中-公开
    单分子检测

    公开(公告)号:US20160192504A1

    公开(公告)日:2016-06-30

    申请号:US14583374

    申请日:2014-12-26

    申请人: INTEL CORPORATION

    IPC分类号: H05K3/10

    摘要: Disclosed herein is a method comprising patterning a second electrode of each of a plurality of electrode pairs onto a substrate; patterning a strip of a sacrificial layer directly across the second electrode; patterning a first electrode of each of the plurality of electrode pairs directly on the strip of the sacrificial layer; forming a nanogap channel by removing the strip of the sacrificial layer; wherein the strip of the sacrificial layer is sandwiched between and in direct contact with the first electrode and the second electrode before the strip is removed, and wherein at least a portion of the first electrode directly faces at least a portion of the second electrode. The method may involve planarization (e.g., CMP). The electrode pairs may be configured such that a redox active molecule can only diffuse back and forth therebetween while it is in the portion of the nanogap channel sandwiched therebetween.

    摘要翻译: 本文公开了一种方法,包括将多个电极对中的每一个的第二电极图案化到衬底上; 直接跨越第二电极图案化牺牲层的条带; 将多个电极对中的每一个的第一电极直接图案化在牺牲层的条上; 通过去除牺牲层的条形成纳米槽通道; 其中所述牺牲层的条带在所述带被去除之前夹在所述第一电极和所述第二电极之间并与之直接接触,并且其中所述第一电极的至少一部分直接面对所述第二电极的至少一部分。 该方法可以涉及平面化(例如,CMP)。 电极对可以被配置为使得氧化还原活性分子只能在夹在其间的纳米隙通道的部分中来回扩散。