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公开(公告)号：US20230257747A1
公开(公告)日：2023-08-17
申请号：US18063972
申请日：2022-12-09
Applicant: Intellia Therapeutics, Inc.
Inventor： Arti Mahendra Prakash Kanjolia , Shobu Odate , Jessica Lynn Seitzer , Reynald Michael Lescarbeau , Walter Strapps
IPC: C12N15/113 , C12N9/22 , C12N15/10 , A61P25/28
CPC classification number: C12N15/113 , A61P25/28 , C12N9/22 , C12N15/102 , A61K48/00 , C12N2310/20
Abstract: Compositions and methods for editing, e.g., introducing double-stranded breaks, within the TTR gene are provided. Compositions and methods for treating subjects having amyloidosis associated with transthyretin (ATTR), are provided.
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公开(公告)号：US20210163943A1
公开(公告)日：2021-06-03
申请号：US17162377
申请日：2021-01-29
Applicant: Intellia Therapeutics, Inc.
Inventor： Zachary William Dymek , Shobu Odate , Bradley Andrew Murray , Reynald Michael Lescarbeau , Anette Huebner , Walter Strapps , Sarah Beth Hesse
IPC: C12N15/113 , C12N9/22 , A61P13/02
Abstract: Compositions and methods for editing, e.g., introducing double-stranded breaks, within the HAO1 gene are provided. Compositions and methods for treating subjects having primary hyperoxaluria type 1 (PH1), are provided.
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3.发明公开公开(公告)号：US20240124897A1
公开(公告)日：2024-04-18
申请号：US18362867
申请日：2023-07-31
Applicant: Intellia Therapeutics, Inc.
Inventor： Yong Chang , Seth C. Alexander , Kristy M. Wood , Arti Mahendra Prakash Kanjolia , Shobu Odate , Jessica Lynn Seitzer , Reynald Michael Lescarbeau , Walter Strapps
CPC classification number: C12N15/907 , C12N9/22 , C12N15/11 , A61K38/00 , C12N2310/20
Abstract: Compositions and methods for editing, e.g., introducing double-stranded breaks, within the TTR gene are provided. Compositions and methods for treating subjects having amyloidosis associated with transthyretin (ATTR), are provided.
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公开(公告)号：US20210222173A1
公开(公告)日：2021-07-22
申请号：US17212901
申请日：2021-03-25
Applicant: Intellia Therapeutics, Inc.
Inventor： Zachary William Dymek , Shobu Odate , Anette Huebner , Srijani Sridhar , Bradley Andrew Murray , Walter Strapps
IPC: C12N15/113 , A61P13/02 , C12N9/22
Abstract: Compositions and methods for editing, e.g., introducing double-stranded breaks, within the LDHA gene are provided. Compositions and methods for treating subjects having hyperoxaluria are provided.
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公开(公告)号：US11795460B2
公开(公告)日：2023-10-24
申请号：US18064086
申请日：2022-12-09
Applicant: Intellia Therapeutics, Inc.
Inventor： Arti Mahendra Prakash Kanjolia , Shobu Odate , Jessica Lynn Seitzer , Reynald Michael Lescarbeau , Walter Strapps
CPC classification number: C12N15/113 , A61P25/28 , C12N9/22 , C12N15/102 , A61K48/00 , A61K48/0091 , C12N15/111 , C12N2310/20 , C12N2310/321 , C12N2800/80
Abstract: Compositions and methods for editing, e.g., introducing double-stranded breaks, within the TTR gene are provided. Compositions and methods for treating subjects having amyloidosis associated with transthyretin (ATTR), are provided.
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Patent Agency Ranking
公开(公告)号：US20230287400A1
公开(公告)日：2023-09-14
申请号：US17900960
申请日：2022-09-01
Applicant: Intellia Therapeutics, Inc.
Inventor： Amy Madison Rhoden Smith , David V. Morrissey , Walter Strapps
CPC classification number: C12N15/11 , C12N9/22 , C12N2310/20 , C12N2310/315 , C12N2310/344 , C12N2310/346 , C12N2320/51
Abstract: This disclosure relates to modified single and dual guide RNAs having improved in vitro and in vivo activity in gene editing methods.
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公开(公告)号：US20230212575A1
公开(公告)日：2023-07-06
申请号：US18063817
申请日：2022-12-09
Applicant: Intellia Therapeutics, Inc.
Inventor： Shobu Odate , Walter Strapps , Reynald Michael Lescarbeau
CPC classification number: C12N15/113 , A61K9/14 , A61K47/28 , A61K47/24 , C12N15/86 , A61K9/5146 , C12N2310/20
Abstract: Compositions and methods for introducing double-stranded breaks within the SERPINA1 gene are provided. Compositions and methods for reducing and eliminating mutant forms of α1-antitrypsin (AAT), such as seen in subjects having α1-antitrypsin deficiency (AATD), are provided.
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公开(公告)号：US20230118592A1
公开(公告)日：2023-04-20
申请号：US18064086
申请日：2022-12-09
Applicant: Intellia Therapeutics, Inc.
Inventor： Arti Mahendra Prakash Kanjolia , Shobu Odate , Jessica Lynn Seitzer , Reynald Michael Lescarbeau , Walter Strapps
IPC: C12N15/113 , C12N9/22 , C12N15/10 , A61P25/28
Abstract: Compositions and methods for editing, e.g., introducing double-stranded breaks, within the TTR gene are provided. Compositions and methods for treating subjects having amyloidosis associated with transthyretin (ATTR), are provided.
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公开(公告)号：US20190316129A1
公开(公告)日：2019-10-17
申请号：US16446764
申请日：2019-06-20
Applicant: Intellia Therapeutics, Inc.
Inventor： Shobu Odate , Walter Strapps , Reynald Michael Lescarbeau
IPC: C12N15/113 , A61K9/14 , A61K47/24 , A61K47/28 , C12N15/86
Abstract: Compositions and methods for introducing double-stranded breaks within the SERPINA1 gene are provided. Compositions and methods for reducing and eliminating mutant forms of al-antitrypsin (AAT), such as seen in subjects having al-antitrypsin deficiency (AATD), are provided.
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公开(公告)号：US20250059532A1
公开(公告)日：2025-02-20
申请号：US18941127
申请日：2024-11-08
Applicant: Intellia Therapeutics, Inc.
Inventor： Amy Madison Rhoden Smith , David V. Morrissey , Walter Strapps
Abstract: This disclosure relates to modified single and dual guide RNAs having improved in vitro and in vivo activity in gene editing methods.
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