公开(公告)号：US4280954A

公开(公告)日：1981-07-28

申请号：US30183

申请日：1979-04-16

申请人： Ioannis V. Yannas ,  Philip L. Gordon ,  Chor Huang ,  Frederick H. Silver ,  John F. Burke

发明人： Ioannis V. Yannas ,  Philip L. Gordon ,  Chor Huang ,  Frederick H. Silver ,  John F. Burke

IPC分类号： A23J1/10 ,  A61F2/00 ,  A61L17/10 ,  A61L27/24 ,  A61L27/26 ,  C08B37/00 ,  C08H1/00

CPC分类号： C08H1/00 ,  A23J1/10 ,  A61L17/10 ,  A61L27/24 ,  A61L27/26 ,  C08B37/0063 ,  A61F2310/00365

摘要： Composite materials are disclosed which are formed by contacting collagen with a mucopolysaccharide and subsequently covalently crosslinking the resultant polymer. These composite materials have a balance of mechanical, chemical and physiological properties which make them useful in surgical sutures and prostheses of controlled biodegradability (resorption) and controlled ability to prevent development of a foreign body reaction, and many are also useful in applications in which blood compatibility is required.

摘要翻译： 公开了通过使胶原与粘多糖接触并随后共价交联所得聚合物而形成的复合材料。 这些复合材料具有机械，化学和生理特性的平衡，使得它们可用于可控生物降解性（吸收）的手术缝线和假体以及防止异物反应发展的受控能力，并且许多也可用于血液 需要兼容性。

公开(公告)号：US4060081A

公开(公告)日：1977-11-29

申请号：US596112

申请日：1975-07-15

申请人： Ioannis V. Yannas ,  John F. Burke ,  Philip L. Gordon ,  Chor Huang

发明人： Ioannis V. Yannas ,  John F. Burke ,  Philip L. Gordon ,  Chor Huang

IPC分类号： B32B9/00 ,  A61F2/00 ,  A61F2/02 ,  A61F2/10 ,  A61L15/22 ,  A61L27/00 ,  A61L27/24 ,  A61L33/10 ,  B01D61/00 ,  B01D71/08 ,  A61L15/00

CPC分类号： A61L27/24 ,  A61F2/105 ,  A61L15/225 ,  A61L27/60 ,  A61F2310/00365 ,  Y10S128/08

摘要： A multilayer membrane, which is useful as synthetic skin, is disclosed herein. A first layer is formed from a material which does not provoke an immune response and which is also insoluble and nondegradable in the presence of body fluids and/or body enzymes. Preferred materials for the first layer are crosslinked composites of collagen and a mucopolysaccharide. A second layer is formed from a nontoxic material which controls the moisture flux of the overall membrane to about 0.1 to 1 mg./cm.sup.2 /hr. Suitable materials for the second layer include synthetic polymers such as silicone resins, polyacrylate or polymethacrylate esters or their copolymers, and polyurethanes.

摘要翻译： 本文公开了可用作合成皮肤的多层膜。 第一层由不引起免疫应答的材料形成，并且在体液和/或体内酶的存在下也是不溶的和不可降解的。 用于第一层的优选材料是胶原和粘多糖的交联复合物。 第二层由无毒材料形成，其将整个膜的水分通量控制在约0.1至1mg./cm 2 / hr。 用于第二层的合适的材料包括合成聚合物，例如硅树脂，聚丙烯酸酯或聚甲基丙烯酸酯或它们的共聚物，以及聚氨酯。