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公开(公告)号：US11890474B2
公开(公告)日：2024-02-06
申请号：US16389816
申请日：2019-04-19
Applicant: IOTA BIOSCIENCES, INC.
Inventor： Jose M. Carmena , Michel M. Maharbiz , Ryan Neely , Joshua Kay
CPC classification number: A61N1/36117 , A61B5/24 , A61N1/3606 , A61N1/36157 , A61N1/36171 , A61N1/36178 , A61N1/3787 , A61N1/37223
Abstract: Described herein are methods for monitoring or modulating an immune system in a subject; treating, reducing or monitoring inflammation; monitoring blood pressure; treating hypertension; or administering or adjusting a therapy for inflammation or hypertension in a patient by electrically stimulating the splenic nerve or detecting splenic nerve activity using an implanted medical device. Also described herein are implantable medical devices for performing such methods. The implanted medical device includes an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy that powers the device, two or more electrodes in electrical communication with the ultrasonic transducer that are configured to electrically stimulate a splenic nerve or detect a splenic nerve activity, and optionally a splenic nerve attachment member.
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Patent Agency Ranking
公开(公告)号：US12233269B2
公开(公告)日：2025-02-25
申请号：US17420336
申请日：2020-01-03
Applicant: Iota Biosciences, Inc.
Inventor： Michel M. Maharbiz , Joshua Kay , Jose M. Carmena
Abstract: Method and system embodiments for controlling power provided to a device implantable in a subject are described. In some embodiments, a method is performed at the implantable device to receive, from an interrogator, powering ultrasonic waves having a wave power. Then, energy from the powering ultrasonic waves is converted into an electrical signal to power the implantable device. Information that indicates whether more power or less power should be transmitted to the implantable device is transmitted to the interrogator.
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公开(公告)号：US20230414950A1
公开(公告)日：2023-12-28
申请号：US18343707
申请日：2023-06-28
Applicant: Iota Biosciences, Inc.
Inventor： Michel M. MAHARBIZ , Ryan Neely , Joshua Kay , Jose M. Carmena
CPC classification number: A61N1/37217 , A61N1/37282 , A61N1/3605 , A61N1/37276 , A61N1/3787 , A61N1/0456
Abstract: Described herein is an implantable medical device that includes a body having one or more ultrasonic transducers configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy, two or more electrodes in electrical communication with the ultrasonic transducer, and a clip attached to the body that is configured to at least partially surround a nerve and/or a filamentous tissue and position the two or more electrodes in electrical communication with the nerve. In certain examples, the implantable medical device includes two ultrasonic transducers with orthogonal polarization axes. Also described herein are methods for treating incontinence in a subject by converting energy from ultrasonic waves into an electrical energy that powers a full implanted medical device, and electrically stimulating a tibial nerve, a pudendal nerve, or a sacral nerve, or a branch thereof, using the fully implanted medical device.
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公开(公告)号：US12226636B2
公开(公告)日：2025-02-18
申请号：US18475136
申请日：2023-09-26
Applicant: Iota Biosciences, Inc.
Inventor： Jose M. Carmena , Michel M. Maharbiz , Ryan Neely , Joshua Kay
Abstract: Described herein are methods for monitoring or modulating an immune system in a subject; treating, reducing or monitoring inflammation; monitoring blood pressure; treating hypertension; or administering or adjusting a therapy for inflammation or hypertension in a patient by electrically stimulating the splenic nerve or detecting splenic nerve activity using an implanted medical device. Also described herein are implantable medical devices for performing such methods. The implanted medical device includes an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy that powers the device, two or more electrodes in electrical communication with the ultrasonic transducer that are configured to electrically stimulate a splenic nerve or detect a splenic nerve activity, and optionally a splenic nerve attachment member.
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公开(公告)号：US11717689B2
公开(公告)日：2023-08-08
申请号：US17324838
申请日：2021-05-19
Applicant: Iota Biosciences, Inc.
Inventor： Michel M. Maharbiz , Ryan Neely , Joshua Kay , Jose M. Carmena
CPC classification number: A61N1/37217 , A61N1/3605 , A61N1/3787 , A61N1/37276 , A61N1/37282 , A61B5/4836 , A61N1/0456
Abstract: Described herein is an implantable medical device that includes a body having one or more ultrasonic transducers configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy, two or more electrodes in electrical communication with the ultrasonic transducer, and a clip attached to the body that is configured to at least partially surround a nerve and/or a filamentous tissue and position the two or more electrodes in electrical communication with the nerve. In certain examples, the implantable medical device includes two ultrasonic transducers with orthogonal polarization axes. Also described herein are methods for treating incontinence in a subject by converting energy from ultrasonic waves into an electrical energy that powers a full implanted medical device, and electrically stimulating a tibial nerve, a pudendal nerve, or a sacral nerve, or a branch thereof, using the fully implanted medical device.
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公开(公告)号：US11033746B2
公开(公告)日：2021-06-15
申请号：US16389876
申请日：2019-04-19
Applicant: IOTA BIOSCIENCES, INC.
Inventor： Michel M. Maharbiz , Ryan Neely , Joshua Kay , Jose M. Carmena
Abstract: Described herein is an implantable medical device that includes a body having one or more ultrasonic transducers configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy, two or more electrodes in electrical communication with the ultrasonic transducer, and a clip attached to the body that is configured to at least partially surround a nerve and/or a filamentous tissue and position the two or more electrodes in electrical communication with the nerve. In certain examples, the implantable medical device includes two ultrasonic transducers with orthogonal polarization axes. Also described herein are methods for treating incontinence in a subject by converting energy from ultrasonic waves into an electrical energy that powers a full implanted medical device, and electrically stimulating a tibial nerve, a pudendal nerve, or a sacral nerve, or a branch thereof, using the fully implanted medical device.
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