公开(公告)号：US6053970A

公开(公告)日：2000-04-25

申请号：US345984

申请日：1999-06-30

申请人： Ira C. Ison ,  Mark T. Fulmer ,  Bryan M. Barr ,  Brent R. Constantz

发明人： Ira C. Ison ,  Mark T. Fulmer ,  Bryan M. Barr ,  Brent R. Constantz

IPC分类号： A61F2/00 ,  A61L27/12 ,  C04B12/02 ,  C04B20/10 ,  C04B28/34 ,  C04B40/06

CPC分类号： C04B20/107 ,  A61L27/12 ,  C04B12/025 ,  C04B20/1077 ,  C04B28/34 ,  C04B28/344 ,  C04B40/06 ,  A61F2310/00293 ,  C04B2111/00836 ,  Y10S623/901 ,  Y10T428/2949 ,  Y10T428/2991 ,  Y10T428/2993

摘要： Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calcium phosphate. The dry component of subject compositions is prepared by combining basic calcium source particles with dissolved acidic phosphate in at least a partially aqueous medium, whereby the basic calcium source particles become partially coated with a partially neutralized acidic calcium phosphate. The reaction is terminated prior to completion of the reaction between the acidic phosphate and the basic calcium source by removing the available water from the reaction mixture. In a first mode, the subject cement may be produced by mechanically mixing an acidic phosphate source with basic calcium source particles in the presence of an aqueous solvent and stopping the reaction between the acid and base prior to completion. Alternatively, a phosphoric acid solution may be rapidly combined with a basic calcium phosphate particle slurry such that partially neutralized acidic calcium phosphate precipitates on the surface of the basic calcium phosphate particles.

摘要翻译： 提供了两种组分的储存稳定的磷灰石水泥组合物，以及它们的生产方法。 受试者磷灰石水泥的干组分包括至少部分涂覆有部分中和的酸性磷酸钙的碱性钙源颗粒。 通过将碱性钙源颗粒与溶解的酸性磷酸盐在至少部分水性介质中组合来制备主体组合物的干组分，由此碱性钙源颗粒部分地涂覆有部分中和的酸性磷酸钙。 在酸性磷酸盐和碱性钙源之间的反应完成之后，通过从反应混合物中除去可用的水来终止反应。 在第一模式中，主体水泥可以通过在水性溶剂的存在下将酸性磷酸盐源与碱性钙源颗粒机械混合并在完成之前停止酸和碱之间的反应来制备。 或者，磷酸溶液可以与碱性磷酸钙颗粒浆料快速组合，使得部分中和的酸性磷酸钙在碱性磷酸钙颗粒的表面上沉淀。

公开(公告)号：US5697981A

公开(公告)日：1997-12-16

申请号：US471408

申请日：1995-06-06

申请人： Ira C. Ison ,  Mark T. Fulmer ,  Bryan M. Barr ,  Brent R. Constantz

发明人： Ira C. Ison ,  Mark T. Fulmer ,  Bryan M. Barr ,  Brent R. Constantz

IPC分类号： A61F2/00 ,  A61L27/12 ,  C04B12/02 ,  C04B20/10 ,  C04B28/34 ,  C04B40/06 ,  A61F2/28

CPC分类号： C04B20/107 ,  A61L27/12 ,  C04B12/025 ,  C04B20/1077 ,  C04B28/34 ,  C04B28/344 ,  C04B40/06 ,  A61F2310/00293 ,  C04B2111/00836 ,  Y10S623/901 ,  Y10T428/2949 ,  Y10T428/2991 ,  Y10T428/2993

摘要： Methods and compositions for use in bone repair are provided. The subject methods employ a two component calcium phosphate cement having a dry component and a lubricant, wherein the dry component of the cement comprises basic calcium phosphate particles at least partially coated with a partially neutralized acidic calcium phosphate. In the subject methods, the dry component and lubricant of the cement are combined to produce a moldable paste which is capable of hardening into a solid mass. The moldable paste may be introduced at a bone repair site and allowed to harden in situ. Alternatively the paste may be allowed to harden and then shaped to obtain a preformed object useful in bone repair.

摘要翻译： 提供了用于骨修复的方法和组合物。 本发明方法采用具有干组分和润滑剂的双组分磷酸钙水泥，其中水泥的干组分包含至少部分涂覆有部分中和的酸性磷酸钙的碱式磷酸钙颗粒。 在本发明的方法中，将水泥的干组分和润滑剂组合以产生能够固化成固体物质的可模制糊料。 可成型糊剂可以在骨修复部位被引入并允许原位硬化。 或者，可以将糊剂硬化，然后成形，以获得可用于骨修复的预成型物体。

公开(公告)号：US5964932A

公开(公告)日：1999-10-12

申请号：US111347

申请日：1998-07-07

申请人： Ira C. Ison ,  Mark T. Fulmer ,  Bryan M. Barr ,  Brent R. Constantz

发明人： Ira C. Ison ,  Mark T. Fulmer ,  Bryan M. Barr ,  Brent R. Constantz

IPC分类号： A61F2/00 ,  A61L27/12 ,  C04B12/02 ,  C04B20/10 ,  C04B28/34 ,  C04B40/06

CPC分类号： C04B20/107 ,  A61L27/12 ,  C04B12/025 ,  C04B20/1077 ,  C04B28/34 ,  C04B28/344 ,  C04B40/06 ,  A61F2310/00293 ,  C04B2111/00836 ,  Y10S623/901 ,  Y10T428/2949 ,  Y10T428/2991 ,  Y10T428/2993

摘要： Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calciumim phosphate. The dry component of subject compositions is prepared by combining basic calcium source particles with dissolved acidic phosphate in at least a partially aqueous medium, whereby the basic calcium source particles become partially coated with a partially neutralized acidic calcium phosphate. The reaction is terminated prior to completion of the reaction between the acidic phosphate and the basic calcium source by removing the available water from the reaction mixture. In a first mode, the subject cement may be produced by mechanically mixing an acidic phosphate source with basic calcium source particles in the presence of an aqueous solvent and stopping the reaction between the acid and base prior to completion. Alternatively, a phosphoric acid solution may be rapidly combined with a basic calcium phosphate particle slurry such that partially neutralized acidic calcium phosphate precipitates on the surface of the basic calcium phosphate particles.

摘要翻译： 提供了两种组分的储存稳定的磷灰石水泥组合物，以及它们的生产方法。 受试者磷灰石水泥的干组分包括至少部分涂覆有部分中和的酸性磷酸钙的碱性钙源颗粒。 通过将碱性钙源颗粒与溶解的酸性磷酸盐在至少部分水性介质中组合来制备主体组合物的干组分，由此碱性钙源颗粒部分地涂覆有部分中和的酸性磷酸钙。 在酸性磷酸盐和碱性钙源之间的反应完成之后，通过从反应混合物中除去可用的水来终止反应。 在第一模式中，主体水泥可以通过在水性溶剂的存在下将酸性磷酸盐源与碱性钙源颗粒机械混合并在完成之前停止酸和碱之间的反应来制备。 或者，磷酸溶液可以与碱性磷酸钙颗粒浆料快速组合，使得部分中和的酸性磷酸钙在碱性磷酸钙颗粒的表面上沉淀。

公开(公告)号：US5846312A

公开(公告)日：1998-12-08

申请号：US886238

申请日：1997-07-01

申请人： Ira C. Ison ,  Mark T. Fulmer ,  Bryan M. Barr ,  Brent R. Constantz

发明人： Ira C. Ison ,  Mark T. Fulmer ,  Bryan M. Barr ,  Brent R. Constantz

IPC分类号： A61F2/00 ,  A61L27/12 ,  C04B12/02 ,  C04B20/10 ,  C04B28/34 ,  C04B40/06

CPC分类号： C04B20/107 ,  A61L27/12 ,  C04B12/025 ,  C04B20/1077 ,  C04B28/34 ,  C04B28/344 ,  C04B40/06 ,  A61F2310/00293 ,  C04B2111/00836 ,  Y10S623/901 ,  Y10T428/2949 ,  Y10T428/2991 ,  Y10T428/2993

摘要： Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calcium phosphate. The dry component of subject compositions is prepared by combining basic calcium source particles with dissolved acidic phosphate in at least a partially aqueous medium, whereby the basic calcium source particles become partially coated with a partially neutralized acidic calcium phosphate. The reaction is terminated prior to completion of the reaction between the acidic phosphate and the basic calcium source by removing the available water from the reaction mixture. In a first mode, the subject cement may be produced by mechanically mixing an acidic phosphate source with basic calcium source particles in the presence of an aqueous solvent and stopping the reaction between the acid and base prior to completion. Alternatively, a phosphoric acid solution may be rapidly combined with a basic calcium phosphate particle slurry such that partially neutralized acidic calcium phosphate precipitates on the surface of the basic calcium phosphate particles.

公开(公告)号：US5683496A

公开(公告)日：1997-11-04

申请号：US645573

申请日：1996-05-14

申请人： Ira C. Ison ,  Mark T. Fulmer ,  Bryan M. Barr ,  Brent R. Constantz

发明人： Ira C. Ison ,  Mark T. Fulmer ,  Bryan M. Barr ,  Brent R. Constantz

IPC分类号： A61F2/00 ,  A61L27/12 ,  C04B12/02 ,  C04B20/10 ,  C04B28/34 ,  C04B40/06

CPC分类号： C04B20/107 ,  A61L27/12 ,  C04B12/025 ,  C04B20/1077 ,  C04B28/34 ,  C04B28/344 ,  C04B40/06 ,  A61F2310/00293 ,  C04B2111/00836 ,  Y10S623/901 ,  Y10T428/2949 ,  Y10T428/2991 ,  Y10T428/2993

摘要： Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calcium phosphate. The dry component of subject compositions is prepared by combining basic calcium source particles with dissolved acidic phosphate in at least a partially aqueous medium, whereby the basic calcium source particles become partially coated with a partially neutralized acidic calcium phosphate. The reaction is terminated prior to completion of the reaction between the acidic phosphate and the basic calcium source by removing the available water from the reaction mixture. In a first mode, the subject cement may be produced by mechanically mixing an acidic phosphate source with basic calcium source particles in the presence of an aqueous solvent and stopping the reaction between the acid and base prior to completion. Alternatively, a phosphoric acid solution may be rapidly combined with a basic calcium phosphate particle slurry such that partially neutralized acidic calcium phosphate precipitates on the surface of the basic calcium phosphate particles.

摘要翻译： 提供了两种组分的储存稳定的磷灰石水泥组合物，以及它们的生产方法。 受试者磷灰石水泥的干组分包括至少部分涂覆有部分中和的酸性磷酸钙的碱性钙源颗粒。 通过将碱性钙源颗粒与溶解的酸性磷酸盐在至少部分水性介质中组合来制备主体组合物的干组分，由此碱性钙源颗粒部分地涂覆有部分中和的酸性磷酸钙。 在酸性磷酸盐和碱性钙源之间的反应完成之后，通过从反应混合物中除去可用的水来终止反应。 在第一模式中，主体水泥可以通过在水性溶剂的存在下将酸性磷酸盐源与碱性钙源颗粒机械混合并在完成之前停止酸和碱之间的反应来制备。 或者，磷酸溶液可以与碱性磷酸钙颗粒浆料快速组合，使得部分中和的酸性磷酸钙在碱性磷酸钙颗粒的表面上沉淀。

公开(公告)号：US5496399A

公开(公告)日：1996-03-05

申请号：US294325

申请日：1994-08-23

申请人： Ira C. Ison ,  Mark T. Fulmer ,  Bryan M. Barr ,  Brent R. Constantz

发明人： Ira C. Ison ,  Mark T. Fulmer ,  Bryan M. Barr ,  Brent R. Constantz

IPC分类号： A61F2/00 ,  A61L27/12 ,  C04B12/02 ,  C04B20/10 ,  C04B28/34 ,  C04B40/06

CPC分类号： C04B20/107 ,  A61L27/12 ,  C04B12/025 ,  C04B20/1077 ,  C04B28/34 ,  C04B28/344 ,  C04B40/06 ,  A61F2310/00293 ,  C04B2111/00836 ,  Y10S623/901 ,  Y10T428/2949 ,  Y10T428/2991 ,  Y10T428/2993

摘要： Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calcium phosphate. The dry component of subject compositions is prepared by combining basic calcium source particles with dissolved acidic phosphate in at least a partially aqueous medium, whereby the basic calcium source particles become partially coated with a partially neutralized acidic calcium phosphate. The reaction is terminated prior to completion of the reaction between the acidic phosphate and the basic calcium source by removing the available water from the reaction mixture. In a first mode, the subject cement may be produced by mechanically mixing an acidic phosphate source with basic calcium source particles in the presence of an aqueous solvent and stopping the reaction between the acid and base prior to completion. Alternatively, a phosphoric acid solution may be rapidly combined with a basic calcium phosphate particle slurry such that partially neutralized acidic calcium phosphate precipitates on the surface of the basic calcium phosphate particles.

公开(公告)号：US5683667A

公开(公告)日：1997-11-04

申请号：US570237

申请日：1995-12-11

申请人： Mark Fulmer ,  Brent R. Constantz ,  Ira C. Ison ,  Bryan M. Barr

发明人： Mark Fulmer ,  Brent R. Constantz ,  Ira C. Ison ,  Bryan M. Barr

IPC分类号： A61L24/00 ,  A61F2/00 ,  A61L24/02 ,  A61L27/12 ,  C01B25/32 ,  C04B12/02 ,  C04B28/34

CPC分类号： C01B25/32 ,  A61L24/02 ,  A61L27/12 ,  C01B25/321 ,  C04B12/02 ,  C04B12/025 ,  C04B28/34 ,  C04B28/344 ,  C04B28/346 ,  A61F2310/00293 ,  C04B2111/00836

摘要： Methods for producing a room temperature stable, phase pure .alpha.-C.sub.3 P product, and compositions derived therefrom, are provided. In the subject method, a tricalcium phosphate source is heated to a temperature sufficient to convert substantially all of said tricalcium phosphate source to a substantially phase pure .alpha.-C.sub.3 P product. The temperature of the resultant product is rapidly cooled to a temperature below about 700.degree. C., resulting in a room temperature stable, reactive .alpha.-C.sub.3 P product. The resultant .alpha.-C.sub.3 P product may be milled to provide an .alpha.-C.sub.3 P composition which may find use in the preparation of calcium phosphate cements.

摘要翻译： 提供了制备室温稳定的纯相α-C3P产物及其衍生物的方法。 在本发明方法中，磷酸三钙源被加热到足以将基本上所有的所述磷酸三钙源转化为基本相纯α-C3P产物的温度。 将所得产物的温度快速冷却至低于约700℃的温度，得到室温稳定的反应性α-C3P产物。 所得到的α-C3P产物可以被研磨以提供可用于制备磷酸钙水泥的α-C3P组合物。

公开(公告)号：US5709742A

公开(公告)日：1998-01-20

申请号：US648318

申请日：1996-05-15

申请人： Mark Fulmer ,  Brent R. Constantz ,  Ira C. Ison ,  Bryan M. Barr

发明人： Mark Fulmer ,  Brent R. Constantz ,  Ira C. Ison ,  Bryan M. Barr

IPC分类号： A61L24/00 ,  A61F2/00 ,  A61L24/02 ,  A61L27/12 ,  C01B25/32 ,  C04B12/02 ,  C04B28/34

CPC分类号： C01B25/32 ,  A61L24/02 ,  A61L27/12 ,  C01B25/321 ,  C04B12/02 ,  C04B12/025 ,  C04B28/34 ,  C04B28/344 ,  C04B28/346 ,  A61F2310/00293 ,  C04B2111/00836

摘要： Methods for producing a room temperature stable, phase pure .alpha.-C.sub.3 P product, and compositions derived therefrom, are provided. In the subject method, a tricalcium phosphate source is heated to a temperature sufficient to convert substantially all of said tricalcium phosphate source to a substantially phase pure .alpha.-C.sub.3 P product. The temperature of the resultant product is rapidly cooled to a temperature below about 700.degree. C., resulting in a room temperature stable, reactive .alpha.-C.sub.3 P product. The resultant .alpha.-C.sub.3 P product may be milled to provide an .alpha.-C.sub.3 P composition which may find use in the preparation of calcium phosphate cements.

公开(公告)号：US5571493A

公开(公告)日：1996-11-05

申请号：US468673

申请日：1995-06-06

申请人： Mark Fulmer ,  Brent R. Constantz ,  Ira C. Ison ,  Bryan M. Barr

发明人： Mark Fulmer ,  Brent R. Constantz ,  Ira C. Ison ,  Bryan M. Barr

IPC分类号： A61L24/00 ,  A61F2/00 ,  A61L24/02 ,  A61L27/12 ,  C01B25/32 ,  C04B12/02 ,  C04B28/34

CPC分类号： C01B25/32 ,  A61L24/02 ,  A61L27/12 ,  C01B25/321 ,  C04B12/02 ,  C04B12/025 ,  C04B28/34 ,  C04B28/344 ,  C04B28/346 ,  A61F2310/00293 ,  C04B2111/00836

摘要： Methods for producing a room temperature stable, phase pure .alpha.-C.sub.3 P product, and compositions derived therefrom, are provided. In the subject method, a tricalcium phosphate source is heated to a temperature sufficient to convert substantially all of said tricalcium phosphate source to a substantially phase pure .alpha.-C.sub.3 P product. The temperature of the resultant product is rapidly cooled to a temperature below about 700.degree. C., resulting in a room temperature stable, reactive .alpha.-C.sub.3 P product. The resultant .alpha.-C.sub.3 P product may be milled to provide an .alpha.-C.sub.3 P composition which may find use in the preparation of calcium phosphate cements.

公开(公告)号：US5569442A

公开(公告)日：1996-10-29

申请号：US334519

申请日：1994-11-04

申请人： Mark Fulmer ,  Brent R. Constantz ,  Ira C. Ison ,  Bryan M. Barr

发明人： Mark Fulmer ,  Brent R. Constantz ,  Ira C. Ison ,  Bryan M. Barr

IPC分类号： A61L24/00 ,  A61F2/00 ,  A61L24/02 ,  A61L27/12 ,  C01B25/32 ,  C04B12/02 ,  C04B28/34

CPC分类号： C01B25/32 ,  A61L24/02 ,  A61L27/12 ,  C01B25/321 ,  C04B12/02 ,  C04B12/025 ,  C04B28/34 ,  C04B28/344 ,  C04B28/346 ,  A61F2310/00293 ,  C04B2111/00836

摘要： Methods for producing a room temperature stable, phase pure .alpha.-C.sub.3 P product, and compositions derived therefrom, are provided. In the subject method, a tricalcium phosphate source is heated to a temperature sufficient to convert substantially all of said tricalcium phosphate source to a substantially phase pure .alpha.-C.sub.3 P product. The temperature of the resultant product is rapidly cooled to a temperature below about 700.degree. C., resulting in a room temperature stable, reactive .alpha.-C.sub.3 P product. The resultant .alpha.-C.sub.3 P product may be milled to provide an .alpha.-C.sub.3 P composition which may find use in the preparation of calcium phosphate cements.

摘要翻译： 提供了制备室温稳定的纯相α-C3P产物及其衍生物的方法。 在本发明方法中，磷酸三钙源被加热到足以将基本上所有的所述磷酸三钙源转化为基本相纯α-C3P产物的温度。 将所得产物的温度快速冷却至低于约700℃的温度，得到室温稳定的反应性α-C3P产物。 所得到的α-C3P产物可以被研磨以提供可用于制备磷酸钙水泥的α-C3P组合物。