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公开(公告)号：US6053970A
公开(公告)日：2000-04-25
申请号：US345984
申请日：1999-06-30
申请人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
发明人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
CPC分类号： C04B20/107 , A61L27/12 , C04B12/025 , C04B20/1077 , C04B28/34 , C04B28/344 , C04B40/06 , A61F2310/00293 , C04B2111/00836 , Y10S623/901 , Y10T428/2949 , Y10T428/2991 , Y10T428/2993
摘要： Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calcium phosphate. The dry component of subject compositions is prepared by combining basic calcium source particles with dissolved acidic phosphate in at least a partially aqueous medium, whereby the basic calcium source particles become partially coated with a partially neutralized acidic calcium phosphate. The reaction is terminated prior to completion of the reaction between the acidic phosphate and the basic calcium source by removing the available water from the reaction mixture. In a first mode, the subject cement may be produced by mechanically mixing an acidic phosphate source with basic calcium source particles in the presence of an aqueous solvent and stopping the reaction between the acid and base prior to completion. Alternatively, a phosphoric acid solution may be rapidly combined with a basic calcium phosphate particle slurry such that partially neutralized acidic calcium phosphate precipitates on the surface of the basic calcium phosphate particles.
摘要翻译： 提供了两种组分的储存稳定的磷灰石水泥组合物，以及它们的生产方法。 受试者磷灰石水泥的干组分包括至少部分涂覆有部分中和的酸性磷酸钙的碱性钙源颗粒。 通过将碱性钙源颗粒与溶解的酸性磷酸盐在至少部分水性介质中组合来制备主体组合物的干组分，由此碱性钙源颗粒部分地涂覆有部分中和的酸性磷酸钙。 在酸性磷酸盐和碱性钙源之间的反应完成之后，通过从反应混合物中除去可用的水来终止反应。 在第一模式中，主体水泥可以通过在水性溶剂的存在下将酸性磷酸盐源与碱性钙源颗粒机械混合并在完成之前停止酸和碱之间的反应来制备。 或者，磷酸溶液可以与碱性磷酸钙颗粒浆料快速组合，使得部分中和的酸性磷酸钙在碱性磷酸钙颗粒的表面上沉淀。
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公开(公告)号：US5697981A
公开(公告)日：1997-12-16
申请号：US471408
申请日：1995-06-06
申请人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
发明人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
CPC分类号： C04B20/107 , A61L27/12 , C04B12/025 , C04B20/1077 , C04B28/34 , C04B28/344 , C04B40/06 , A61F2310/00293 , C04B2111/00836 , Y10S623/901 , Y10T428/2949 , Y10T428/2991 , Y10T428/2993
摘要： Methods and compositions for use in bone repair are provided. The subject methods employ a two component calcium phosphate cement having a dry component and a lubricant, wherein the dry component of the cement comprises basic calcium phosphate particles at least partially coated with a partially neutralized acidic calcium phosphate. In the subject methods, the dry component and lubricant of the cement are combined to produce a moldable paste which is capable of hardening into a solid mass. The moldable paste may be introduced at a bone repair site and allowed to harden in situ. Alternatively the paste may be allowed to harden and then shaped to obtain a preformed object useful in bone repair.
摘要翻译： 提供了用于骨修复的方法和组合物。 本发明方法采用具有干组分和润滑剂的双组分磷酸钙水泥，其中水泥的干组分包含至少部分涂覆有部分中和的酸性磷酸钙的碱式磷酸钙颗粒。 在本发明的方法中，将水泥的干组分和润滑剂组合以产生能够固化成固体物质的可模制糊料。 可成型糊剂可以在骨修复部位被引入并允许原位硬化。 或者，可以将糊剂硬化，然后成形，以获得可用于骨修复的预成型物体。
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公开(公告)号：US5964932A
公开(公告)日：1999-10-12
申请号：US111347
申请日：1998-07-07
申请人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
发明人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
CPC分类号： C04B20/107 , A61L27/12 , C04B12/025 , C04B20/1077 , C04B28/34 , C04B28/344 , C04B40/06 , A61F2310/00293 , C04B2111/00836 , Y10S623/901 , Y10T428/2949 , Y10T428/2991 , Y10T428/2993
摘要： Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calciumim phosphate. The dry component of subject compositions is prepared by combining basic calcium source particles with dissolved acidic phosphate in at least a partially aqueous medium, whereby the basic calcium source particles become partially coated with a partially neutralized acidic calcium phosphate. The reaction is terminated prior to completion of the reaction between the acidic phosphate and the basic calcium source by removing the available water from the reaction mixture. In a first mode, the subject cement may be produced by mechanically mixing an acidic phosphate source with basic calcium source particles in the presence of an aqueous solvent and stopping the reaction between the acid and base prior to completion. Alternatively, a phosphoric acid solution may be rapidly combined with a basic calcium phosphate particle slurry such that partially neutralized acidic calcium phosphate precipitates on the surface of the basic calcium phosphate particles.
摘要翻译： 提供了两种组分的储存稳定的磷灰石水泥组合物，以及它们的生产方法。 受试者磷灰石水泥的干组分包括至少部分涂覆有部分中和的酸性磷酸钙的碱性钙源颗粒。 通过将碱性钙源颗粒与溶解的酸性磷酸盐在至少部分水性介质中组合来制备主体组合物的干组分，由此碱性钙源颗粒部分地涂覆有部分中和的酸性磷酸钙。 在酸性磷酸盐和碱性钙源之间的反应完成之后，通过从反应混合物中除去可用的水来终止反应。 在第一模式中，主体水泥可以通过在水性溶剂的存在下将酸性磷酸盐源与碱性钙源颗粒机械混合并在完成之前停止酸和碱之间的反应来制备。 或者，磷酸溶液可以与碱性磷酸钙颗粒浆料快速组合，使得部分中和的酸性磷酸钙在碱性磷酸钙颗粒的表面上沉淀。
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公开(公告)号：US5846312A
公开(公告)日：1998-12-08
申请号：US886238
申请日：1997-07-01
申请人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
发明人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
CPC分类号： C04B20/107 , A61L27/12 , C04B12/025 , C04B20/1077 , C04B28/34 , C04B28/344 , C04B40/06 , A61F2310/00293 , C04B2111/00836 , Y10S623/901 , Y10T428/2949 , Y10T428/2991 , Y10T428/2993
摘要： Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calcium phosphate. The dry component of subject compositions is prepared by combining basic calcium source particles with dissolved acidic phosphate in at least a partially aqueous medium, whereby the basic calcium source particles become partially coated with a partially neutralized acidic calcium phosphate. The reaction is terminated prior to completion of the reaction between the acidic phosphate and the basic calcium source by removing the available water from the reaction mixture. In a first mode, the subject cement may be produced by mechanically mixing an acidic phosphate source with basic calcium source particles in the presence of an aqueous solvent and stopping the reaction between the acid and base prior to completion. Alternatively, a phosphoric acid solution may be rapidly combined with a basic calcium phosphate particle slurry such that partially neutralized acidic calcium phosphate precipitates on the surface of the basic calcium phosphate particles.
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公开(公告)号：US5683496A
公开(公告)日：1997-11-04
申请号：US645573
申请日：1996-05-14
申请人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
发明人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
CPC分类号： C04B20/107 , A61L27/12 , C04B12/025 , C04B20/1077 , C04B28/34 , C04B28/344 , C04B40/06 , A61F2310/00293 , C04B2111/00836 , Y10S623/901 , Y10T428/2949 , Y10T428/2991 , Y10T428/2993
摘要： Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calcium phosphate. The dry component of subject compositions is prepared by combining basic calcium source particles with dissolved acidic phosphate in at least a partially aqueous medium, whereby the basic calcium source particles become partially coated with a partially neutralized acidic calcium phosphate. The reaction is terminated prior to completion of the reaction between the acidic phosphate and the basic calcium source by removing the available water from the reaction mixture. In a first mode, the subject cement may be produced by mechanically mixing an acidic phosphate source with basic calcium source particles in the presence of an aqueous solvent and stopping the reaction between the acid and base prior to completion. Alternatively, a phosphoric acid solution may be rapidly combined with a basic calcium phosphate particle slurry such that partially neutralized acidic calcium phosphate precipitates on the surface of the basic calcium phosphate particles.
摘要翻译： 提供了两种组分的储存稳定的磷灰石水泥组合物，以及它们的生产方法。 受试者磷灰石水泥的干组分包括至少部分涂覆有部分中和的酸性磷酸钙的碱性钙源颗粒。 通过将碱性钙源颗粒与溶解的酸性磷酸盐在至少部分水性介质中组合来制备主体组合物的干组分，由此碱性钙源颗粒部分地涂覆有部分中和的酸性磷酸钙。 在酸性磷酸盐和碱性钙源之间的反应完成之后，通过从反应混合物中除去可用的水来终止反应。 在第一模式中，主体水泥可以通过在水性溶剂的存在下将酸性磷酸盐源与碱性钙源颗粒机械混合并在完成之前停止酸和碱之间的反应来制备。 或者，磷酸溶液可以与碱性磷酸钙颗粒浆料快速组合，使得部分中和的酸性磷酸钙在碱性磷酸钙颗粒的表面上沉淀。
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公开(公告)号：US5496399A
公开(公告)日：1996-03-05
申请号：US294325
申请日：1994-08-23
申请人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
发明人： Ira C. Ison , Mark T. Fulmer , Bryan M. Barr , Brent R. Constantz
CPC分类号： C04B20/107 , A61L27/12 , C04B12/025 , C04B20/1077 , C04B28/34 , C04B28/344 , C04B40/06 , A61F2310/00293 , C04B2111/00836 , Y10S623/901 , Y10T428/2949 , Y10T428/2991 , Y10T428/2993
摘要： Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calcium phosphate. The dry component of subject compositions is prepared by combining basic calcium source particles with dissolved acidic phosphate in at least a partially aqueous medium, whereby the basic calcium source particles become partially coated with a partially neutralized acidic calcium phosphate. The reaction is terminated prior to completion of the reaction between the acidic phosphate and the basic calcium source by removing the available water from the reaction mixture. In a first mode, the subject cement may be produced by mechanically mixing an acidic phosphate source with basic calcium source particles in the presence of an aqueous solvent and stopping the reaction between the acid and base prior to completion. Alternatively, a phosphoric acid solution may be rapidly combined with a basic calcium phosphate particle slurry such that partially neutralized acidic calcium phosphate precipitates on the surface of the basic calcium phosphate particles.
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公开(公告)号：US6002065A
公开(公告)日：1999-12-14
申请号：US820126
申请日：1997-03-19
CPC分类号： A61L24/02 , A61K6/0038 , A61K6/033 , A61K6/0643 , A61K6/0668 , A61K6/0675 , A61L27/12 , A61F2310/00293 , Y10S623/923
摘要： Setting times of calcium phosphate cement compositions are enhanced by the addition of phosphate or carbonate lubricant compositions. Methods for preparing the cement compositions are provided.
摘要翻译： 通过添加磷酸盐或碳酸盐润滑剂组合物可提高磷酸钙水泥组合物的凝固时间。 提供了制备水泥组合物的方法。
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公开(公告)号：US5820632A
公开(公告)日：1998-10-13
申请号：US221646
申请日：1994-04-01
IPC分类号： A61K47/02 , A61F2/00 , A61F2/02 , A61F2/28 , A61K6/033 , A61L24/02 , A61L27/00 , A61L27/12 , A61L27/46 , A61L27/50 , A61L27/58 , C01B25/16 , C01B25/32 , C01B25/455 , C01B15/16
CPC分类号： A61K6/033 , A61K6/0023 , A61K6/0038 , A61K6/0085 , A61K6/0643 , A61K6/0668 , A61K6/0675 , A61L24/02 , A61L27/12 , A61L27/46 , A61L27/50 , A61L27/58 , C01B25/16 , C01B25/32 , C01B25/322 , C01B25/327 , C01B25/455 , A61F2002/2817 , A61F2002/30062 , A61F2210/0004 , A61F2310/00293 , Y10S623/901
摘要： Setting times of calcium phosphate cement compositions are enhanced by the addition of phosphate or carbonate lubricant compositions. Methods for preparing the cement compositions are provided.
摘要翻译： 通过添加磷酸盐或碳酸盐润滑剂组合物可提高磷酸钙水泥组合物的凝固时间。 提供了制备水泥组合物的方法。
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公开(公告)号：US5336264A
公开(公告)日：1994-08-09
申请号：US918233
申请日：1992-07-23
申请人： Brent R. Constanz , Mark T. Fulmer , Bryan M. Barr
发明人： Brent R. Constanz , Mark T. Fulmer , Bryan M. Barr
IPC分类号： A61K47/02 , A61F2/00 , A61F2/02 , A61F2/28 , A61K6/033 , A61L24/02 , A61L27/00 , A61L27/12 , A61L27/46 , A61L27/50 , A61L27/58 , C01B25/16 , C01B25/32 , C01B25/455 , C01B15/16
CPC分类号： A61K6/033 , A61K6/0023 , A61K6/0038 , A61K6/0085 , A61K6/0643 , A61K6/0668 , A61K6/0675 , A61L24/02 , A61L27/12 , A61L27/46 , A61L27/50 , A61L27/58 , C01B25/16 , C01B25/32 , C01B25/322 , C01B25/327 , C01B25/455 , A61F2002/2817 , A61F2002/30062 , A61F2210/0004 , A61F2310/00293 , Y10S623/901
摘要： Setting times of calcium phosphate cement compositions are enhanced by the addition of phosphate or carbonate lubricant compositions. Methods for preparing the cement compositions are provided.
摘要翻译： 通过添加磷酸盐或碳酸盐润滑剂组合物可提高磷酸钙水泥组合物的凝固时间。 提供了制备水泥组合物的方法。
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公开(公告)号：US06793660B2
公开(公告)日：2004-09-21
申请号：US09932313
申请日：2001-08-20
申请人： Sean H. Kerr , Mark T. Fulmer
发明人： Sean H. Kerr , Mark T. Fulmer
IPC分类号： A61B1756
CPC分类号： A61B17/8822 , A61B17/3472 , A61F2/28 , A61F2/4601 , A61F2310/00353 , A61M37/0069
摘要： The invention relates to a syringe for delivery of a bone substitute material. The syringe includes a barrel for holding the material, a plunger receivable within the barrel and having a threaded portion, and an engagement member including a threaded throughbore positioned coaxial with the barrel. The threaded portion of the plunger is movable through the threaded throughbore barrel by pushing the plunger in the axial direction, and by rotating the plunger. The invention also relates to a method of expelling material from a syringe.
摘要翻译： 本发明涉及一种用于输送骨替代材料的注射器。 注射器包括用于保持材料的筒，可接收在筒体内并具有螺纹部分的柱塞，以及包括与筒体同轴设置的螺纹通孔的接合构件。 柱塞的螺纹部分通过沿着轴向推动柱塞并且通过旋转柱塞可移动穿过螺纹穿孔筒。 本发明还涉及从注射器排出材料的方法。
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