公开(公告)号：US20140113314A1

公开(公告)日：2014-04-24

申请号：US13689722

申请日：2012-11-29

申请人： Ira S. Cohen ,  Zhongju Lu ,  Richard B. Robinson ,  Irvin B. Krukenkamp ,  Peter R. Brink ,  Steven J. Feinmark

发明人： Ira S. Cohen ,  Zhongju Lu ,  Richard B. Robinson ,  Irvin B. Krukenkamp ,  Peter R. Brink ,  Steven J. Feinmark

IPC分类号： G01N33/566

CPC分类号： G01N33/566 ,  A61K31/00

摘要： The present invention relates to methods and compositions for modulating the activity of two-pore domain K+ channels (“K2P channels”) as a means for inducing preconditioning protection. Such preconditioning can be used to reduce the effect of ischemia associated with ischemic heart disease, myocardial infarction or cardiac surgery. The invention is based on the discovery that the myoprotective current induced by short periods of ischemia is carried by a non-classical two-pore domain K+ channel.

摘要翻译： 本发明涉及用于调节双孔结构域K +通道（“K2P通道”）作为诱导预处理保护的手段的活性的方法和组合物。 这种预处理可用于减少与缺血性心脏病，心肌梗死或心脏手术相关的缺血的作用。 本发明基于以下发现：由短期缺血引起的肌保护电流由非经典双孔结构域K +通道携带。