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1.发明申请Two Pore Channels as a Therapeutic Target to Protect Against Myocardial Ischemia and as an Adjuvant in Cardiac Surgery 审中-公开两个孔道作为治疗心肌缺血和辅助治疗心脏手术的治疗靶点公开(公告)号：US20140113314A1
公开(公告)日：2014-04-24
申请号：US13689722
申请日：2012-11-29
申请人： Ira S. Cohen , Zhongju Lu , Richard B. Robinson , Irvin B. Krukenkamp , Peter R. Brink , Steven J. Feinmark
发明人： Ira S. Cohen , Zhongju Lu , Richard B. Robinson , Irvin B. Krukenkamp , Peter R. Brink , Steven J. Feinmark
IPC分类号： G01N33/566
CPC分类号： G01N33/566 , A61K31/00
摘要： The present invention relates to methods and compositions for modulating the activity of two-pore domain K+ channels (“K2P channels”) as a means for inducing preconditioning protection. Such preconditioning can be used to reduce the effect of ischemia associated with ischemic heart disease, myocardial infarction or cardiac surgery. The invention is based on the discovery that the myoprotective current induced by short periods of ischemia is carried by a non-classical two-pore domain K+ channel.
摘要翻译： 本发明涉及用于调节双孔结构域K +通道（“K2P通道”）作为诱导预处理保护的手段的活性的方法和组合物。 这种预处理可用于减少与缺血性心脏病，心肌梗死或心脏手术相关的缺血的作用。 本发明基于以下发现：由短期缺血引起的肌保护电流由非经典双孔结构域K +通道携带。
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2.发明申请TWO PORE CHANNELS AS A THERAPEUTIC TARGET TO PROTECT AGAINST MYOCARDIAL ISCHEMIA AND AS AN ADJUVANT IN CARDIAC SURGERY 审中-公开两个通道作为治疗心肌梗塞并作为心脏手术的受试者的治疗目标公开(公告)号：US20100048650A1
公开(公告)日：2010-02-25
申请号：US12296017
申请日：2007-04-04
申请人： Ira S. Cohen , Zhongju Lu , Irvin Krukenkamp , Peter R. Brink , Richard B. Robinson , Steven J. Feinmark
发明人： Ira S. Cohen , Zhongju Lu , Irvin Krukenkamp , Peter R. Brink , Richard B. Robinson , Steven J. Feinmark
IPC分类号： A61K31/426 , A61K31/23 , A61K31/40 , A61K31/216 , C12N5/00 , G01N33/53 , C12Q1/02 , A61P9/00
CPC分类号： G01N33/566 , A61K31/00
摘要： The present invention relates to methods and compositions for modulating the activity of two-pore domain K+ channels (“K2P channels”) as a means for inducing preconditioning protection. Such preconditioning can be used to reduce the effect of ischemia associated with ischemic heart disease, myocardial infarcation or cardiac surgery. The invention is based on the discovery that the myoprotective current induced by short periods of ischemia is carried by a non-classical two-pore domain K+ channel.
摘要翻译： 本发明涉及用于调节双孔结构域K +通道（“K2P通道”）作为诱导预处理保护的手段的活性的方法和组合物。 这种预处理可用于减少与缺血性心脏病，心肌梗塞或心脏手术相关的局部缺血的作用。 本发明基于以下发现：由短期缺血引起的肌保护电流由非经典双孔结构域K +通道携带。
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3.发明申请Biological Bypass Bridge with Sodium Channels, Calcium Channels and/or Potassium Channels to Compensate for Conduction Block in the Heart 审中-公开具有钠通道，钙通道和/或钾通道的生物旁路桥，用于补偿心脏中的传导阻滞公开(公告)号：US20130110218A1
公开(公告)日：2013-05-02
申请号：US13535013
申请日：2012-06-27
IPC分类号： A61N1/05
CPC分类号： A61N1/0587 , C12N5/0663 , C12N2502/1329 , C12N2510/00
摘要： This invention provides a bypass bridge comprising a tract of gap junction-coupled cells having a first end and a second end, both ends capable of being attached to two selected sites in a heart so as to allow the conduction of a pacemaker and/or electrical signal/current across the tract between the two sites, wherein the cells functionally express a sodium channel. The invention also provides related methods of making the bypass bridge, methods of implanting same in a heart, and methods of treating a disorder associated with an impaired conduction in a subject's heart.
摘要翻译： 本发明提供了一种旁路桥，其包括一段具有第一端和第二端的间隙连接耦合的电池，两端能够连接到心脏中的两个选定位置，以允许起搏器和/或电气 在两个位点之间的通道之间的信号/电流，其中细胞在功能上表达钠通道。 本发明还提供了制造旁路桥的相关方法，在心脏中植入其的方法，以及治疗与受试者心脏中的传导受损有关的障碍的方法。
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4.发明申请公开(公告)号：US20110223144A1
公开(公告)日：2011-09-15
申请号：US13109804
申请日：2011-05-17
CPC分类号： A61L27/3873 , A61L27/3834 , A61L27/3895 , C12N5/0663 , C12N2502/1329
摘要： A method of creating an atrioventricular bypass tract for a heart comprises growing mesenchymal stem cells into a strip with two ends, attaching one end of the strip onto the atrium of the heart, and attaching the other end of the strip to the ventricle of the heart, to create a tract connecting the atrium to the ventricle to provide a path for electrical signals generated by the sinus node to propagate across the tract and excite the ventricle.
摘要翻译： 为心脏产生房室旁路的方法包括将间充质干细胞生长成具有两端的条带，将条带的一端附接到心脏的心房上，并将带的另一端附接到心脏的心室 ，以产生将心房连接到心室的路径，以提供由窦房结产生的电信号通过道路传播并激发心室的路径。
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5.发明申请Delivery of DNA or RNA via gap junctions from host cells to target cells and a cell-based delivery system for antisense or siRNA 有权通过从宿主细胞到靶细胞的间隙连接递送DNA或RNA，以及用于反义或siRNA的基于细胞的递送系统公开(公告)号：US20110076773A1
公开(公告)日：2011-03-31
申请号：US12910346
申请日：2010-10-22
CPC分类号： A61K48/0083 , C12N15/87
摘要： A method of delivering an oligonucleotide or a plasmid expressing an oligonucleotide into a target cell comprises introducing an oligonucleotide into a donor cell, particularly a stem cell, and contacting the target cell with the donor cell under conditions permitting the donor cell to form a gap junction with the target cell, whereby the oligonucleotide or a product of the oligonucleotide is delivered into the target cell from the donor cell.
摘要翻译： 将寡核苷酸或表达寡核苷酸的质粒递送到靶细胞的方法包括将寡核苷酸引入供体细胞，特别是干细胞，并在允许供体细胞形成间隙连接的条件下使靶细胞与供体细胞接触 与靶细胞接触，由此寡核苷酸或寡核苷酸的产物从供体细胞输送到靶细胞中。
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公开(公告)号：US20110041857A1
公开(公告)日：2011-02-24
申请号：US12744568
申请日：2008-11-26
申请人： Adam J.T. Schuldt , Peter R. Brink , Ira S. Cohen , Michael R. Rosen , Richard B. Robinson , Glenn Gaudette
发明人： Adam J.T. Schuldt , Peter R. Brink , Ira S. Cohen , Michael R. Rosen , Richard B. Robinson , Glenn Gaudette
CPC分类号： C12N5/0662 , C12N5/0657 , C12N2506/1307 , C12N2533/32
摘要： The present invention provides methods and compositions relating to the production of stem cells, derived from dedifferentiated fibroblasts, and the use of such stem cells for treatment of a variety of different disorders and conditions. The invention is based on the surprising discovery that a population of stem cells, capable of differentiating into a variety of different cell types, can be generated by culturing fibroblasts under selective culture conditions.
摘要翻译： 本发明提供了与衍生于去分化成纤维细胞的干细胞的生产有关的方法和组合物，以及这些干细胞用于治疗各种不同疾病和病症的用途。 本发明基于令人惊奇的发现，即可以通过在选择性培养条件下培养成纤维细胞来产生能够分化成多种不同细胞类型的干细胞群体。
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7.发明申请公开(公告)号：US20120260355A1
公开(公告)日：2012-10-11
申请号：US13517094
申请日：2010-12-22
申请人： Ira S. Cohen , Thomas W. White , Richard B. Robinson , Peter R. Brink , Richard T. Mathias , Michael R. Rosen
发明人： Ira S. Cohen , Thomas W. White , Richard B. Robinson , Peter R. Brink , Richard T. Mathias , Michael R. Rosen
IPC分类号： A61K49/00
CPC分类号： G01N33/5088 , C12Q1/6897 , C12Q2525/207
摘要： The present invention provides a method for testing the efficiency of delivering an inhibitory polynucleotide to a target cell or tissue. The invention also provides a method for testing efficiency of delivering and efficacy for an effect on tumor size of an inhibitory polynucleotide against a target gene.
摘要翻译： 本发明提供了一种用于测试将抑制性多核苷酸递送至靶细胞或组织的效率的方法。 本发明还提供了一种用于测试递送效率的方法以及对靶基因的抑制性多核苷酸对肿瘤大小的影响的效力。
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8.发明授权公开(公告)号：US07968126B2
公开(公告)日：2011-06-28
申请号：US10584303
申请日：2004-12-22
CPC分类号： A61L27/3873 , A61L27/3834 , A61L27/3895 , C12N5/0663 , C12N2502/1329
摘要： A method of creating an atrioventricular bypass tract for a heart comprises growing mesenchymal stem cells into a strip with two ends, attaching one end of the strip onto the atrium of the heart, and attaching the other end of the strip to the ventricle of the heart, to create a tract connecting the atrium to the ventricle to provide a path for electrical signals generated by the sinus node to propagate across the tract and excite the ventricle.
摘要翻译： 为心脏产生房室旁路的方法包括将间充质干细胞生长成具有两端的条带，将条带的一端附接到心脏的心房上，并将带的另一端附接到心脏的心室 ，以产生将心房连接到心室的路径，以提供由窦房结产生的电信号通过道路传播并激发心室的路径。
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9.发明申请USE OF LATE PASSAGE MESENCHYMAL STEM CELLS (MSCS) FOR TREATMENT OF CARDIAC RHYTHM DISORDERS 审中-公开用于治疗心脏疾病的最常用的中枢神经干细胞（MSCS）的使用公开(公告)号：US20100049273A1
公开(公告)日：2010-02-25
申请号：US12374030
申请日：2007-07-20
申请人： Glenn Gaudette , Irina A. Potapova , Peter R. Brink , Ira S. Cohen , Richard B. Robinson , Michael R. Rosen
发明人： Glenn Gaudette , Irina A. Potapova , Peter R. Brink , Ira S. Cohen , Richard B. Robinson , Michael R. Rosen
CPC分类号： C12N5/0663 , A61K35/12 , C12N2502/1329 , C12N2510/00 , C12N2510/02
摘要： The present invention provides methods and compositions relating to the use of late passage mesenchymal stem cells (MSCs) for treatment of cardiac rhythm disorders. The late passage MSCs of the invention may be used to provide biological pacemaker activity and/or provide a bypass bridge in the heart of a subject afflicted with a cardiac rhythm disorder. The biological pacemaker activity and/or bypass bridge may be provided to the subject either alone or in tandem with an electronic pacemaker.
摘要翻译： 本发明提供了与晚期传代间充质干细胞（MSC）用于治疗心律失常有关的方法和组合物。 本发明的晚期传代MSC可用于提供生物起搏器活动和/或在患有心律失常的受试者的心脏中提供旁路桥。 生物起搏器活动和/或旁通桥可以单独提供或与电子起搏器串联提供给受试者。
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10.发明申请公开(公告)号：US20080247998A1
公开(公告)日：2008-10-09
申请号：US10584303
申请日：2005-07-14
CPC分类号： A61L27/3873 , A61L27/3834 , A61L27/3895 , C12N5/0663 , C12N2502/1329
摘要： A method of creating an atrioventricular bypass tract for a heart comprises growing mesenchymal stem cells into a strip with two ends, attaching one end of the strip onto the atrium of the heart, and attaching the other end of the strip to the ventricle of the heart, to create a tract connecting the atrium to the ventricle to provide a path for electrical signals generated by the sinus node to propagate across the tract and excite the ventricle.
摘要翻译： 为心脏产生房室旁路的方法包括将间充质干细胞生长成具有两端的条带，将条带的一端附接到心脏的心房上，并将带的另一端附接到心脏的心室 ，以产生将心房连接到心室的路径，以提供由窦房结产生的电信号通过道路传播并激发心室的路径。
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