利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

8 条记录 (耗时 0.035 秒)

    OSMOTIC DOSAGE FORM WITH CONTROLLED RELEASE AND FAST RELEASE ASPECTS
    4.
    发明申请
    OSMOTIC DOSAGE FORM WITH CONTROLLED RELEASE AND FAST RELEASE ASPECTS 审中-公开
    OSMOTIC剂型与控制释放和快速释放方面

    公开(公告)号：US20070166381A1

    公开(公告)日：2007-07-19

    申请号：US11619468

    申请日：2007-01-03

    申请人： Iran Reyes ,  Julie Lee ,  Brian Barclay ,  Iswadi Liejanto ,  Nipun Davar

    发明人： Iran Reyes ,  Julie Lee ,  Brian Barclay ,  Iswadi Liejanto ,  Nipun Davar

    IPC分类号： A61K9/24

    CPC分类号： A61K9/0004 ,  A61K31/506

    摘要： Disclosed are osmotic dosage forms and methods that provide for fast release of drugs together with controlled release of drugs. In an aspect, disclosed are osmotic dosage forms including: a semi-permeable membrane; a lubricating subcoat located within the semi-permeable membrane; an orifice in the semi-permeable membrane located at an end of the semi-permeable membrane; a drug layer located adjacent to the orifice and within the lubricating subcoat; a push layer located within the lubricating subcoat and on a side of the drug layer opposite from the orifice; wherein an area of the orifice is greater than or equal to about 1,600 mil2; and wherein the drug layer comprises from about 20 wt % to about 90 wt % microcrystalline cellulose, and less than or equal to about 10 wt % of a drug, based on the total weight of the drug layer. Also disclosed are methods of making osmotic dosage forms.

    摘要翻译： 公开了提供药物快速释放以及药物控制释放的渗透剂型和方法。 一方面，所公开的是渗透剂型，包括：半透膜; 位于半透膜内的润滑底涂层; 位于半透膜端部的半透膜中的孔口; 邻近孔口并位于润滑底涂层内的药物层; 位于所述润滑底层内并且在所述药物层的与所述孔相对的一侧的推层; 其中所述孔口的面积大于或等于约1,600密耳2; 并且其中基于药物层的总重量，药物层包含约20重量％至约90重量％的微晶纤维素和小于或等于约10重量％的药物。 还公开了制备渗透剂型的方法。

    METHODS AND DOSAGE FORMS FOR CONTROLLED DELIVERY OF PALIPERIDONE AND RISPERIDONE
    5.
    发明申请
    METHODS AND DOSAGE FORMS FOR CONTROLLED DELIVERY OF PALIPERIDONE AND RISPERIDONE 审中-公开
    用于控制输送PALIPERIDONE和RISPERIDONE的方法和剂型

    公开(公告)号：US20090202631A1

    公开(公告)日：2009-08-13

    申请号：US12428422

    申请日：2009-04-22

    申请人： Nyomi V. Yam ,  Iran Reyes ,  Nipun Davar ,  Atul D. Ayer ,  Julie Lee ,  Sonya Seroff ,  Suneel K. Gupta ,  Gayatri Sathyan

    发明人： Nyomi V. Yam ,  Iran Reyes ,  Nipun Davar ,  Atul D. Ayer ,  Julie Lee ,  Sonya Seroff ,  Suneel K. Gupta ,  Gayatri Sathyan

    IPC分类号： A61K31/519 ,  A61K9/20

    CPC分类号： A61K9/0004 ,  A61K9/0053 ,  A61K9/2086 ,  A61K9/209 ,  A61K31/506 ,  A61K31/519

    摘要： Dosage forms and methods for providing a substantially ascending rate of release of paliperidone or risperidone are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma paliperidone or risperidone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma paliperidone or risperidone concentration occurrence in each 24 hour period. In addition, the peak plasma paliperidone or risperidone concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma paliperidone or risperidone concentration that occurs following administration of paliperidone or risperidone in an immediate-release dosage form.

    摘要翻译： 提供了用于提供帕培酮或利培酮的基本上升释放速率的剂型和方法。 当每天施用一次时，持续释放剂型提供治疗有效的平均稳态血浆普利培酮或利培酮浓度。 这种每天一次的给药方案导致每24小时内出现一次峰值血浆普利培酮或利培酮浓度。 此外，剂量给药后的较晚时间，峰值血浆普利培酮或利培酮浓度发生在比立即释放剂型给药帕立哌酮或利培酮后出现的峰值血浆普利培酮或利培酮浓度更小的程度。

    Methods and dosage forms for controlled delivery of paliperidone and risperidone
    8.
    发明申请
    Methods and dosage forms for controlled delivery of paliperidone and risperidone 审中-公开
    受控输送帕培培酮和利培酮的方法和剂型

    公开(公告)号：US20050232995A1

    公开(公告)日：2005-10-20

    申请号：US11051165

    申请日：2005-02-04

    申请人： Nyomi Yam ,  Iran Reyes ,  Nipun Davar ,  Atul Ayer ,  Julie Lee ,  Sonya Seroff ,  Suneel Gupta ,  Gayatri Sathyan

    发明人： Nyomi Yam ,  Iran Reyes ,  Nipun Davar ,  Atul Ayer ,  Julie Lee ,  Sonya Seroff ,  Suneel Gupta ,  Gayatri Sathyan

    IPC分类号： A61K31/506 ,  A61K31/519 ,  A61K9/24

    CPC分类号： A61K9/0004 ,  A61K9/0053 ,  A61K9/2086 ,  A61K9/209 ,  A61K31/506 ,  A61K31/519

    摘要： Dosage forms and methods for providing a substantially ascending rate of release of paliperidone or risperidone are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma paliperidone or risperidone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma paliperidone or risperidone concentration occurrence in each 24 hour period. In addition, the peak plasma paliperidone or risperidone concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma paliperidone or risperidone concentration that occurs following administration of paliperidone or risperidone in an immediate-release dosage form.

    摘要翻译： 提供了用于提供帕培酮或利培酮的基本上升释放速率的剂型和方法。 当每天施用一次时，持续释放剂型提供治疗有效的平均稳态血浆普利培酮或利培酮浓度。 这种每天一次的给药方案导致每24小时内出现一次峰值血浆普利培酮或利培酮浓度。 此外，剂量给药后的较晚时间，峰值血浆普利培酮或利培酮浓度发生在比立即释放剂型给药帕立哌酮或利培酮后出现的峰值血浆普利培酮或利培酮浓度更小的程度。