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公开(公告)号：US08524749B2
公开(公告)日：2013-09-03
申请号：US12014980
申请日：2008-01-16
申请人： Scott Bull , Suneel Gupta , Rhea Donley , Nishit Modi , Noymi Yam
发明人： Scott Bull , Suneel Gupta , Rhea Donley , Nishit Modi , Noymi Yam
IPC分类号： A61K31/433 , A61P21/00
CPC分类号： A61K31/433
摘要： The present invention relates to a novel controlled release formulations of tizanidine. The invention also provides methods of using novel controlled release formulations of tizanidine to treat a patient.
摘要翻译： 本发明涉及替扎尼定的新型控释制剂。 本发明还提供使用替扎尼定的新型控制释放制剂治疗患者的方法。
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2.发明申请Dosage forms for low solubility and or low dissolution rate free acid pharmaceutical agents 审中-公开用于低溶解度或低溶解度游离酸药剂的剂型公开(公告)号：US20050287213A1
公开(公告)日：2005-12-29
申请号：US11148679
申请日：2005-06-08
申请人： Patrick Wong , Noymi Yam , Sherry Li
发明人： Patrick Wong , Noymi Yam , Sherry Li
CPC分类号： A61K9/0004
摘要： An osmotic controlled release dosage form is described comprising a core comprising a first drug composition, wherein the first drug composition comprises topiramate and/or its pharmaceutically acceptable salt; a semi-permeable wall surrounding the core; and an exit orifice through the semi-permeable wall for releasing the first drug composition from the dosage form over a prolonged period of time.
摘要翻译： 描述渗透控制释放剂型，其包含包含第一药物组合物的核心，其中所述第一药物组合物包含托吡酯和/或其药学上可接受的盐; 围绕芯的半透壁; 以及通过半透壁的出口孔，用于在长时间内从剂型释放第一药物组合物。
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公开(公告)号：US20050136113A1
公开(公告)日：2005-06-23
申请号：US11051194
申请日：2005-02-04
申请人： Padmanabh Bhatt , Evangeline Cruz , Noymi Yam
发明人： Padmanabh Bhatt , Evangeline Cruz , Noymi Yam
IPC分类号： A61K9/22 , A61K9/00 , A61K9/28 , A61K9/52 , A61K31/496 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/32 , A61K47/34 , A61K47/38 , A61K47/42 , A61P25/24 , A61K9/24
CPC分类号： A61K9/0004
摘要： Controlled release of active agents from sustained release push delivery devices having high drug loading are described wherein residual drug content in the device is minimized by the utilization of a flow-promoting layer between a semi-permeable wall and drug layer comprising the device.
摘要翻译： 描述了活性剂从具有高药物负荷的持续释放推送递送装置的控制释放，其中通过在包含该装置的半渗透性壁和药物层之间利用促进流动来使装置中的残留药物含量最小化。
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公开(公告)号：US20070243254A1
公开(公告)日：2007-10-18
申请号：US11737829
申请日：2007-06-28
申请人： David Edgren , Frank Jao , Rhea Kimbel , Padmaja Shivanand , Atul Ayer , Gurdish Bhatti , Andrew Lam , Shu Li , Robert Skluzacek , Winnie To , Patrick Wong , Shaoling Li , Noymi Yam , Sylvia Serofff
发明人： David Edgren , Frank Jao , Rhea Kimbel , Padmaja Shivanand , Atul Ayer , Gurdish Bhatti , Andrew Lam , Shu Li , Robert Skluzacek , Winnie To , Patrick Wong , Shaoling Li , Noymi Yam , Sylvia Serofff
CPC分类号： A61K9/0004
摘要： The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmaceutical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and/or low dissolution rate pharmaceutical agents. The present invention is further directed to methods for manufacturing of said drug compositions and dosage forms. The present invention is further directed to methods of treatment comprising administration of said drug compositions and dosage forms.
摘要翻译： 本发明涉及包含所述药物组合物的新型药物组合物和剂型。 本发明的药物组合物包含药剂和增溶剂。 本发明的药物组合物特别适用于低溶解度和/或低溶解速率的药剂。 本发明还涉及制备所述药物组合物和剂型的方法。 本发明进一步涉及包括施用所述药物组合物和剂型的治疗方法。
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5.发明申请公开(公告)号：US20070026067A1
公开(公告)日：2007-02-01
申请号：US11495111
申请日：2006-07-28
申请人： Noymi Yam , Nipun Davar , Gayatri Sathyan , Suneel Gupta
发明人： Noymi Yam , Nipun Davar , Gayatri Sathyan , Suneel Gupta
IPC分类号： A61K9/22 , A61K31/519 , A61K31/42
CPC分类号： A61K31/519 , A61K9/0004 , A61K9/4891 , A61K31/42
摘要： Disclosed are dosage forms including a controlled release dosing structure; and a liquid formulation contained within the controlled release dosing structure; wherein the liquid formulation comprises a benzisoxazole derivative and a liquid carrier. Also disclosed are methods of making and using such dosage forms.
摘要翻译： 公开了包括控释剂量结构的剂型; 和包含在控释剂量结构内的液体制剂; 其中液体制剂包含苯并异恶唑衍生物和液体载体。 还公开了制备和使用这些剂型的方法。
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公开(公告)号：US20080214629A1
公开(公告)日：2008-09-04
申请号：US12014980
申请日：2008-01-16
申请人： Scott Bull , Suneel Gupta , Rhea Donley , Nishit Modi , Noymi Yam
发明人： Scott Bull , Suneel Gupta , Rhea Donley , Nishit Modi , Noymi Yam
IPC分类号： A61K31/433 , A61P21/00
CPC分类号： A61K31/433
摘要： The present invention relates to a novel controlled release formulations of tizanidine. The invention also provides methods of using novel controlled release formulations of tizanidine to treat a patient.
摘要翻译： 本发明涉及替扎尼定的新型控释制剂。 本发明还提供使用替扎尼定的新型控制释放制剂治疗患者的方法。
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公开(公告)号：US20050175690A1
公开(公告)日：2005-08-11
申请号：US11024330
申请日：2004-12-28
申请人： David Edgren , Frank Jao , Rhea Kimbel , Shaoling Li , Noymi Yam , Sylvia Seroff , Padmaja Shivanand
发明人： David Edgren , Frank Jao , Rhea Kimbel , Shaoling Li , Noymi Yam , Sylvia Seroff , Padmaja Shivanand
CPC分类号： A61K9/209 , A61K9/0004
摘要： The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmaceutical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and/or low dissolution rate pharmaceutical agents. The present invention is further directed to methods for manufacturing of said drug compositions and dosage forms. The present invention is further directed to methods of treatment comprising administration of said drug compositions and dosage forms.
摘要翻译： 本发明涉及包含所述药物组合物的新型药物组合物和剂型。 本发明的药物组合物包含药剂和增溶剂。 本发明的药物组合物特别适用于低溶解度和/或低溶解速率的药剂。 本发明还涉及制备所述药物组合物和剂型的方法。 本发明进一步涉及包括施用所述药物组合物和剂型的治疗方法。
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8.发明申请Methods and dosage forms for increasing solubility of drug compositions for controlled delivery 审中-公开用于增加药物组合物用于受控递送的溶解度的方法和剂型公开(公告)号：US20050169992A1
公开(公告)日：2005-08-04
申请号：US11023257
申请日：2004-12-22
申请人： Frank Jao , David Edgren , Robert Skluzacek , Noymi Yam
发明人： Frank Jao , David Edgren , Robert Skluzacek , Noymi Yam
CPC分类号： A61K9/0004 , A61K31/7004
摘要： Dosage forms and devices for enhancing controlled delivery of pharmaceutical agents by use of a drug core composition that increases the solubility of the pharmaceutical agent are described. The present invention provides a means of delivering high doses of poorly soluble drug in oral drug delivery systems that are convenient to swallow, for once-a-day administration.
摘要翻译： 描述了通过使用提高药剂的溶解度的药物核心组合物增强药剂的受控递送的剂型和装置。 本发明提供了一种在口服药物递送系统中递送高剂量的难溶性药物的方法，其便于吞咽，每天一次给药。
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公开(公告)号：US06855334B2
公开(公告)日：2005-02-15
申请号：US10001116
申请日：2001-11-27
申请人： Padmanabh Bhatt , Evangeline Cruz , Noymi Yam
发明人： Padmanabh Bhatt , Evangeline Cruz , Noymi Yam
IPC分类号： A61K9/22 , A61K9/00 , A61K9/28 , A61K9/52 , A61K31/496 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/32 , A61K47/34 , A61K47/38 , A61K47/42 , A61P25/24 , A61K9/24 , A61K9/44
CPC分类号： A61K9/0004
摘要： Controlled release of active agents from sustained release push delivery devices having high drug loading are described wherein residual drug content in the device is minimized by the utilization of a flow-promoting layer between a semi-permeable wall and drug layer comprising the device.
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公开(公告)号：US06368626B1
公开(公告)日：2002-04-09
申请号：US09430837
申请日：1999-11-01
申请人： Padmanabh Bhatt , Evangeline Cruz , Noymi Yam
发明人： Padmanabh Bhatt , Evangeline Cruz , Noymi Yam
IPC分类号： A61K922
CPC分类号： A61K9/0004
摘要： Controlled release of active agents from sustained release push delivery devices having high drug loading are described wherein residual drug content in the device is minimized by the utilization of a flow-promoting layer between a semi-permeable wall and drug layer comprising the device.
摘要翻译： 描述了活性剂从具有高药物负载的持续释放推送递送装置的控制释放，其中通过在包含该装置的半渗透性壁和药物层之间利用流动促进层来最小化装置中的残留药物含量。
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