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1.发明授权Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells 失效编码具有乙酰肝素酶活性并在遗传修饰细胞中表达相同的多肽的多核苷酸公开(公告)号：US06664105B1
公开(公告)日：2003-12-16
申请号：US09435739
申请日：1999-11-08
申请人： Iris Pecker , Israel Vlodavsky , Elena Feinstein
发明人： Iris Pecker , Israel Vlodavsky , Elena Feinstein
IPC分类号： C12Q168
CPC分类号： C12Y302/01166 , A61K38/00 , A61L27/34 , A61M15/009 , C07K16/40 , C12N9/2402 , G01N33/573 , G01N2333/988 , G01N2400/40
摘要： A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression are provided.
摘要翻译： 提供了编码具有乙酰肝素酶活性的多肽（包括其的载体），表达肝素酶的遗传修饰的细胞，具有乙酰肝素酶活性的重组蛋白质和反义寡核苷酸的多核苷酸（hpa）和用于调节肝素酶表达的构建体。
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公开(公告)号：US07666651B2
公开(公告)日：2010-02-23
申请号：US09776874
申请日：2001-02-06
申请人： Iris Pecker , Israel Vlodavsky , Elena Feinstein
发明人： Iris Pecker , Israel Vlodavsky , Elena Feinstein
CPC分类号： C12Y302/01166 , A61K38/00 , C12N9/2402
摘要： A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression.
摘要翻译： 编码具有乙酰肝素酶活性的多肽的多核苷酸（hpa），包含其的载体，表达乙酰肝素酶的遗传修饰的细胞，具有乙酰肝素酶活性的重组蛋白和反义寡核苷酸以及用于调节肝素酶表达的构建体。
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公开(公告)号：US20050260187A1
公开(公告)日：2005-11-24
申请号：US11106672
申请日：2005-04-15
申请人： Neta Ilan , Israel Vlodavsky , Oron Yacoby-Zeevi , Iris Pecker , Elena Feinstein
发明人： Neta Ilan , Israel Vlodavsky , Oron Yacoby-Zeevi , Iris Pecker , Elena Feinstein
CPC分类号： A61K38/47 , A61K31/00 , C12N9/2402 , C12Y302/01166
摘要： Methods and compositions for inducing and/or accelerating wound healing and/or angiogenesis via the catalytic activity of heparanase are disclosed.
摘要翻译： 公开了通过乙酰肝素酶的催化活性诱导和/或加速伤口愈合和/或血管生成的方法和组合物。
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公开(公告)号：US06790658B2
公开(公告)日：2004-09-14
申请号：US09988113
申请日：2001-11-19
申请人： Iris Pecker , Israel Vlodavsky , Elena Feinstein
发明人： Iris Pecker , Israel Vlodavsky , Elena Feinstein
IPC分类号： C12N1556
CPC分类号： C12Y302/01166 , A61K38/00 , C12N9/2402
摘要： A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression.
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5.发明申请Polynucleotide encoding A polypeptide having heparanase activity and expression of same in genetically modified cells 审中-公开编码具有乙酰肝素酶活性并在遗传修饰细胞中表达相同的多肽的多核苷酸公开(公告)号：US20090275106A1
公开(公告)日：2009-11-05
申请号：US11978666
申请日：2007-10-30
申请人： Iris Pecker , Israel Vlodavsky , Elena Feinstein
发明人： Iris Pecker , Israel Vlodavsky , Elena Feinstein
IPC分类号： C12N9/88
CPC分类号： C12Y302/01166 , A61K38/00 , C12N9/2402
摘要： A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression.
摘要翻译： 编码具有乙酰肝素酶活性的多肽的多核苷酸（hpa），包含其的载体，表达乙酰肝素酶的遗传修饰的细胞，具有乙酰肝素酶活性的重组蛋白质和反义寡核苷酸以及用于调节乙酰肝素酶表达的构建体。
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6.发明授权Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells 失效编码具有乙酰肝素酶活性并在遗传修饰细胞中表达相同的多肽的多核苷酸公开(公告)号：US06960471B2
公开(公告)日：2005-11-01
申请号：US10384450
申请日：2003-03-10
申请人： Iris Pecker , Israel Vlodavsky , Elena Feinstein
发明人： Iris Pecker , Israel Vlodavsky , Elena Feinstein
IPC分类号： A61K38/00 , C07H21/04 , C12N1/21 , C12N5/06 , C12N5/10 , C12N9/24 , C12N15/56 , C12N15/63 , C12P21/02 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C12Y302/01166 , A61K38/00 , C12N9/2402
摘要： A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression.
摘要翻译： 编码具有乙酰肝素酶活性的多肽的多核苷酸（hpa），包含其的载体，表达乙酰肝素酶的遗传修饰的细胞，具有乙酰肝素酶活性的重组蛋白和反义寡核苷酸以及用于调节肝素酶表达的构建体。
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7.发明授权Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells 失效编码具有乙酰肝素酶活性并在转导细胞中表达相同的多肽的多核苷酸
公开(公告)号：US5968822A
公开(公告)日：1999-10-19
申请号：US922170
申请日：1997-09-02
申请人： Iris Pecker , Israel Vlodavsky , Elena Feinstein
发明人： Iris Pecker , Israel Vlodavsky , Elena Feinstein
IPC分类号： G01N33/50 , A61K9/00 , A61K38/00 , A61K38/46 , A61K38/51 , A61K39/395 , A61L27/34 , A61M15/00 , A61P9/10 , A61P17/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07K16/40 , C12N1/21 , C12N5/10 , C12N9/24 , C12N15/09 , C12N15/56 , C12P21/08 , C12Q1/34 , C12Q1/527 , C12Q1/68 , G01N33/15 , G01N33/573 , C12N15/63
CPC分类号： C12Y302/01166 , A61L27/34 , A61M15/009 , C07K16/40 , C12N9/2402 , G01N33/573 , A61K38/00 , G01N2333/988 , G01N2400/40
摘要： A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, transduced cells expressing heparanase and a recombinant protein having heparanase activity.
摘要翻译： 编码具有乙酰肝素酶活性的多肽的多核苷酸（hpa），包含其的载体，表达肝素酶的转导细胞和具有乙酰肝素酶活性的重组蛋白。
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公开(公告)号：US09056903B2
公开(公告)日：2015-06-16
申请号：US13233907
申请日：2011-09-15
申请人： Elena Feinstein , Rami Skaliter
发明人： Elena Feinstein , Rami Skaliter
IPC分类号： C12N15/113 , C07K16/18 , C07K14/47 , C07K16/22 , A61K39/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/4747 , C07K16/22 , C12N15/113 , C12N2310/14 , C12N2310/321 , C12N2310/3521
摘要： The present invention provides novel molecules, compositions, methods and uses for treating microvascular disorders, eye diseases respiratory conditions and hearing disorders based upon inhibition of the RTP801 gene and/or protein.
摘要翻译： 本发明提供了基于RTP801基因和/或蛋白质的抑制来治疗微血管病症，眼部疾病呼吸系统疾病和听力障碍的新型分子，组合物，方法和用途。
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公开(公告)号：US09045755B2
公开(公告)日：2015-06-02
申请号：US13700942
申请日：2011-06-23
IPC分类号： C07H21/04 , C12N15/113
CPC分类号： C12N15/1135 , C12N15/1137 , C12N2310/14 , C12N2310/141 , C12N2310/321 , C12Q1/6888
摘要： The present invention relates to compounds, pharmaceutical compositions comprising same, methods of use thereof and kits for the down-regulation of RhoA gene. The compounds, compositions, methods and kits are useful in the treatment of subjects suffering from diseases or conditions and or symptoms associated with diseases or conditions in which RhoA expression has adverse consequences and for conferring neuroprotection.
摘要翻译： 本发明涉及化合物，包含其的药物组合物，其使用方法和用于下调RhoA基因的试剂盒。 化合物，组合物，方法和试剂盒可用于治疗患有RhoA表达具有不良后果和赋予神经保护作用的疾病或病症和/或与疾病或病症相关的症状的受试者。
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10.发明申请DOUBLE-STRANDED OLIGONUCLEOTIDE COMPOUNDS FOR TREATING HEARING AND BALANCE DISORDERS 审中-公开用于治疗听觉和平衡障碍的双链寡核苷酸化合物公开(公告)号：US20150018404A1
公开(公告)日：2015-01-15
申请号：US14235780
申请日：2012-08-03
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/332 , C12N2310/333 , C12N2310/3341 , C12N2310/335 , C12N2310/336 , C12N2310/337 , C12N2310/3521 , C12N2310/50
摘要： The present application relates to double stranded nucleic acid compounds, compositions comprising same and methods of use thereof for the treatment of hearing loss in a subject in need thereof. The compounds are preferably chemically synthesized and modified dsRNA molecules which inhibit expression of a gene expressed selected from the group consisting of HES1, HES5, HEY1, HEY2, ID1, ID2, ID3, CDKN1B, and NOTCH1.
摘要翻译： 本申请涉及双链核酸化合物，包含其的组合物以及用于治疗有此需要的受试者的听力损失的方法。 所述化合物优选化学合成并抑制表达选自HES1，HES5，HEY1，HEY2，ID1，ID2，ID3，CDKN1B和NOTCH1的基因表达的dsRNA分子。
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