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公开(公告)号：US4971804A
公开(公告)日：1990-11-20
申请号：US305081
申请日：1989-02-02
CPC分类号： A61K31/19 , A61K9/5073
摘要： A water-dispersible formulation of gemfibrozil comprising finely divided particles of pure gemfibrozil uniformly coated with a mixture of a wax and at least one hydrophilic material, the coated particles in turn being overcoated with a minor amount of a surfactant.
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公开(公告)号：US4810501A
公开(公告)日：1989-03-07
申请号：US875146
申请日：1986-06-17
CPC分类号： A61K9/5078 , A61K47/48184 , A61K9/143
摘要： Sustained release solid dosage forms--i.e., tablets, pellets, granules, and powders--can be made using a combination of polymeric and ionic particulate materials to modify release profiles, permeability and processability.
摘要翻译： 可以使用聚合物和离子颗粒材料的组合来制备缓释固体剂型，即片剂，丸剂，颗粒剂和粉剂，以改变释放曲线，渗透性和加工性。
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公开(公告)号：US4925676A
公开(公告)日：1990-05-15
申请号：US305083
申请日：1989-02-02
申请人： Isaac Ghebre-Sellassie , Uma Iyer , Mahdi B. Fawzi
发明人： Isaac Ghebre-Sellassie , Uma Iyer , Mahdi B. Fawzi
CPC分类号： A61K31/19 , A61K9/2081
摘要： A disintegratable gemfibrozil tablet providing both immediate and enteric release is compressed from a mixture of a first granulation of gemfibrozil with at least one acid-disintegratable binder and a second granulation formed from the first granulation but regranulated or coated with an alkali-disintegratable formulation of at least one substantially alkali-soluble and substantially acid-insoluble polymer.
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公开(公告)号：US4814354A
公开(公告)日：1989-03-21
申请号：US912903
申请日：1986-09-26
CPC分类号： A61K9/5042 , A61K31/785 , A61K9/0056
摘要： Cholestyramine can be administered orally along with one or more other lipid regulating agent(s) and/or other beneficial agent(s) in compositions in which the cholestyramine has been suitably pretreated.
摘要翻译： 在已经适当预处理消胆胺的组合物中，胆钙清蛋白可以与一种或多种其它脂质调节剂和/或其它有益剂一起口服给药。
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公开(公告)号：US06677362B1
公开(公告)日：2004-01-13
申请号：US08218495
申请日：1994-03-28
申请人： Isaac Ghebre-Sellassie , Robert Reisch, Jr. , Riten Parikh , Mahdi B. Fawzi , Russell U. Nesbitt
发明人： Isaac Ghebre-Sellassie , Robert Reisch, Jr. , Riten Parikh , Mahdi B. Fawzi , Russell U. Nesbitt
IPC分类号： A61K31425
CPC分类号： A61K9/146 , A61K9/1694
摘要： A novel solid pharmaceutical dispersion that improves the bioavailability of poorly water soluble drugs is produced by combining the drug with a polymer carrier such as polyvinylpyrrolidone. The drug is combined with the carrier without the need for using organic solvents or melting temperatures (fusion) through the use of a transition compound such as polyethylene glycol which partially solubilizes the drug and/or plasticizes the polymer.
摘要翻译： 通过将药物与聚合物载体如聚乙烯吡咯烷酮组合来提高改善水溶性差的药物的生物利用度的新型固体药物分散体。 该药物与载体组合，而不需要通过使用部分溶解药物和/或增塑聚合物的过渡化合物例如聚乙二醇来使用有机溶剂或熔融温度（融合）。
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公开(公告)号：US5281421A
公开(公告)日：1994-01-25
申请号：US873511
申请日：1992-04-16
CPC分类号： A61K47/26 , A61K31/19 , A61K47/20 , A61K9/2013 , Y10S514/824 , Y10S514/929 , Y10S514/96 , Y10S514/975
摘要： Improved oral formulations are prepared by admixing gemfibrozil with from 1 to 4%, by weight, of a pharmaceutically acceptable surfactant having an HLB value of from about 10 to about 50.
摘要翻译： 通过将吉非贝齐与1至4重量％的HLB值为约10至约50的药学上可接受的表面活性剂混合来制备改进的口服制剂。
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7.发明授权
公开(公告)号：US5032405A
公开(公告)日：1991-07-16
申请号：US413197
申请日：1989-09-27
CPC分类号： A61K9/4891 , A61K9/4858 , A61K9/4866 , Y10S514/888
摘要： An orally administrable formulation of a biologically active, acid sensitive, proteinaceous agent comprises a composition of a lyophilized mixture of the proteinaceous agent and maltose, optionally with a particulate diluent. This composition is then uniformly coated with an alkaline-soluble polymeric film containing at least one partially esterified polymethacrylic acid as a major component.
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公开(公告)号：US4687776A
公开(公告)日：1987-08-18
申请号：US922646
申请日：1986-10-24
IPC分类号： C07D215/26 , A61K31/47 , C07D215/22 , C07D215/227 , C07D215/32
CPC分类号： C07D215/227 , Y10T436/10
摘要： Certain derivatives of procaterol are believed to possess similar biological activity to the base compound, (i.e., as bronchodilators) but have greater stability and bioavailability.
摘要翻译： 认为丙卡特罗的某些衍生物与碱性化合物（即，作为支气管扩张剂）具有相似的生物学活性，但具有更大的稳定性和生物利用度。
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9.发明授权
公开(公告)号：US5358723A
公开(公告)日：1994-10-25
申请号：US57203
申请日：1993-05-04
申请人： Isaac Ghebre-Sellassie , Uma Iyer
发明人： Isaac Ghebre-Sellassie , Uma Iyer
CPC分类号： A61K31/19 , A61K9/2077
摘要： Gemfibrozil formulations prepared from a single granulation of gemfibrozil and a release-control agent are disclosed. The release-control agent is present in an amount sufficient to provide both immediate and controlled release of gemfibrozil. A method of preparing the formulation and a compressed tablet are also disclosed.
摘要翻译： 公开了由吉非贝齐的单次造粒和释放控制剂制备的吉非贝齐配方。 释放控制剂的存在量足以提供吉非贝齐的即时和控制释放。 还公开了制备制剂的方法和压制片剂。
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10.发明授权
公开(公告)号：US5492700A
公开(公告)日：1996-02-20
申请号：US280385
申请日：1994-07-26
申请人： Isaac Ghebre-Sellassie , Uma Iyer
发明人： Isaac Ghebre-Sellassie , Uma Iyer
CPC分类号： A61K31/19 , A61K9/1635 , A61K9/1652 , A61K9/2077
摘要： Gemfibrozil formulations prepared from a single granulation of gemfibrozil and a release-control agent are disclosed. The release-control agent is present in an amount sufficient to provide both immediate and controlled release of gemfibrozil. A method of preparing the formulation and a compressed tablet are also disclosed.
摘要翻译： 公开了由吉非贝齐的单次造粒和释放控制剂制备的吉非贝齐配方。 释放控制剂的存在量足以提供吉非贝齐的即时和控制释放。 还公开了制备制剂的方法和压制片剂。
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