公开(公告)号：US08013115B1

公开(公告)日：2011-09-06

申请号：US10048978

申请日：2000-08-14

申请人： Isabelle Nathalie Garric ,  Isabelle Karine Giuliani ,  Catherine Christiane Marie Larue ,  François Yves Rieunier ,  Sylvie Marie-France Trinquier

发明人： Isabelle Nathalie Garric ,  Isabelle Karine Giuliani ,  Catherine Christiane Marie Larue ,  François Yves Rieunier ,  Sylvie Marie-France Trinquier

IPC分类号： C07K7/50 ,  G01N33/68

CPC分类号： G01N33/531 ,  G01N33/6887 ,  G01N2333/4712

摘要： The invention concerns the use of at least a synthetic compound comprising: a carrier molecule having at least a hydrocarbon chain comprising at least 10, advantageously at least 12, preferably at least 14 and not more than 300, advantageously not more than 100, preferably not more than 50, selected'among C, N, O, S, P and Si, and comprising at least two reactive functions, or capable of reacting, for grafting lateral arms on said chain, and at least two different epitopes carried by said lateral arms grafted on said carrier molecule, as standard or control for immunoassay of said biological molecules, in particular of polypeptides or proteins.

摘要翻译： 本发明涉及使用至少一种合成化合物，其包括：载体分子，其具有至少包含至少10个，有利地至少12个，优选至少14个，且不多于300个，有利地不多于100个，优选不大于100个的烃链 超过50个，选择的C，N，O，S，P和Si，并且包含至少两个反应性函数，或能够反应，用于接枝所述链上的侧臂，以及至少两个不同的表位， 作为标准的移植在所述载体分子上的臂，所述生物分子尤其是多肽或蛋白质的免疫测定的对照。

公开(公告)号：US07053175B1

公开(公告)日：2006-05-30

申请号：US09147362

申请日：1998-04-06

申请人： Denis Marie Bernárd Chenebaux ,  Jean-Francois Hubert Delagneau ,  Stephane Jean Xavier Gadelle ,  François Yves Rieunier

发明人： Denis Marie Bernárd Chenebaux ,  Jean-Francois Hubert Delagneau ,  Stephane Jean Xavier Gadelle ,  François Yves Rieunier

IPC分类号： A61K38/00

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N7/00 ,  C12N2740/16122

摘要： Synthetic peptides of the monomer type with 13 to 33 amino acids, in linear form or in a form cyclized by means of inter-cysteine disulphide bridges, have the general formula (I): Δ-Z-TrpGlyCys-Θ-CysTyrThrSer-Ω  (I) wherein Δ is a biotinyl radical, a biocytinyl radical, a hydrogen atom, an acetyl (CH3CO—) radical, an aliphatic chain which may contain one or two thiol, an aldehyde functional group, or an amine functional group, Z represents peptide sequence -Ξ1-Ser-Ξ2-, -Ξ1-Gln-Ξ2-, or -Ξ1-Asn-Ξ2-, wherein -Ξ1 represents a peptide sequence of 0 to 9 amino acids and -Ξ2 represents a peptide sequence of 0 to 5 amino acids, Θ is -Arg Gly Arg Leu Ile-(SEQ ID NO: 15), -Arg Gly Arg Leu Val-(SEQ ID NO: 16), -Arg Gly Lys Leu Ile- (SEQ ID NO: 17), -Arg Gly Lys Leu Val-(SEQ ID NO: 18), -Lys Gly Arg Leu Ile-(SEQ ID NO: 19), or -Lys Gly Arg Leu Val-(SEQ ID NO: 20), Ω, attached to the —CO— group of serine, is a hydroxyl (—OH) radical, an amino (—NH2) radical, an alkoxy radical having 1 to 6 carbon atoms, a peptide sequence of formula Val-Σ-Ψ wherein Σ represents a sequence of formula -(AA1)-Trp Asn-(AA2)-(AA3) wherein (AA1) represents an amino acid different from lysine, (AA2) represents an amino acid, and (AA3) is serine or a threonine residue, and Ψ, attached to the —CO— residue of the free AA3 amino acid, is OH, NH2, or an alkoxy radical having from 1 to 6 carbon atoms, and a peptide sequence of formula -Val-Ψ wherein Ψ, attached to the —CO— residue of valine, is OH, NH2, or an alkoxy radical having from 1 to 6 carbon atoms.