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公开(公告)号：US20160068845A1
公开(公告)日：2016-03-10
申请号：US14814174
申请日：2015-07-30
发明人： C. Frank Bennett , Susan M. Freier , Robert A. MacLeod , Sanjay K. Pandey , Charles A. Thornton , Thurman Wheeler , Seng H. Cheng , Andrew Leger , Bruce M. Wentworth
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12Y207/11 , C12N2310/322 , C12N2310/3533 , C12N2310/3527
摘要： Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preferentially reducing CUGexp DMPK RNA, reducing myotonia or reducing spliceopathy in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate type 1 myotonic dystrophy, or a symptom thereof.
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2.发明申请MODULATION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 (STAT3) EXPRESSION 审中-公开信号传导器的调制和转录3（STAT3）表达的激活剂公开(公告)号：US20160348104A1
公开(公告)日：2016-12-01
申请号：US15149642
申请日：2016-05-09
IPC分类号： C12N15/113
摘要： Disclosed herein are antisense compounds and methods for decreasing STAT3 mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate hyperproliferative diseases.
摘要翻译： 本文公开了用于降低STAT3 mRNA和蛋白质表达的反义化合物和方法。 这些方法，化合物和组合物可用于治疗，预防或改善过度增殖性疾病。
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公开(公告)号：US10479993B2
公开(公告)日：2019-11-19
申请号：US15149642
申请日：2016-05-09
IPC分类号： C07H21/00 , C12N15/113 , C07H21/04 , C12N15/00 , C12N15/11
摘要： Disclosed herein are antisense compounds and methods for decreasing STAT3 mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate hyperproliferative diseases.
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公开(公告)号：US09765338B2
公开(公告)日：2017-09-19
申请号：US14814174
申请日：2015-07-30
发明人： C. Frank Bennett , Susan M. Freier , Robert A. MacLeod , Sanjay K. Pandey , Charles A. Thornton , Thurman Wheeler , Seng H. Cheng , Andrew Leger , Bruce M. Wentworth
IPC分类号： C12N15/11 , C12N15/113
CPC分类号： C12N15/1137 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12Y207/11 , C12N2310/322 , C12N2310/3533 , C12N2310/3527
摘要： Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preferentially reducing CUGexp DMPK RNA, reducing myotonia or reducing spliceopathy in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate type 1 myotonic dystrophy, or a symptom thereof.
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5.发明授权Modulation of signal transducer and activator of transcription 3 (STAT3) expression 有权信号转导和转录激活因子3（STAT3）表达的调控公开(公告)号：US09359608B2
公开(公告)日：2016-06-07
申请号：US14338880
申请日：2014-07-23
CPC分类号： C12N15/113 , C07H21/00 , C07H21/04 , C12N15/00 , C12N15/11 , C12N15/1135 , C12N2310/11 , C12N2310/315 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/321 , C12N2310/3521 , C12N2310/3525
摘要： Disclosed herein are antisense compounds and methods for decreasing STAT3 mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate hyperproliferative diseases.
摘要翻译： 本文公开了用于降低STAT3 mRNA和蛋白质表达的反义化合物和方法。 这些方法，化合物和组合物可用于治疗，预防或改善过度增殖性疾病。
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6.发明申请METHODS FOR MODULATING METASTASIS-ASSOCIATED-IN-LUNG-ADENOCARCINOMA-TRANSCRIPT-1 (MALAT-1) EXPRESSION 有权METASTASIS-ASSOCIATED-IN-LUNG-ADENOCARCINOMA-TransCRIPT-1（MALAT-1）表达调控方法公开(公告)号：US20140371296A1
公开(公告)日：2014-12-18
申请号：US14368269
申请日：2012-12-21
IPC分类号： C12N15/113
CPC分类号： C12N15/1136 , A61K31/711 , C12N15/113 , C12N2310/11 , C12N2310/113 , C12N2310/315 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/321 , C12N2310/3525
摘要： The present embodiments provide compounds and methods for reducing expression of Metastasis-Associated-in-Lung-Adenocarcinoma-Transcript-1 (MALAT-1) RNA and/or protein in an animal. Such methods are useful for treating cancer, such as colon cancer, intestinal cancer, lung cancer (e.g. non-small cell lung cancer), liver cancer, and/or prostate cancer. In various aspects, the cancer is a primary cancer.
摘要翻译： 本实施方案提供了用于在动物中减少转移相关的肺 - 腺癌 - 转录物-1（MALAT-1）RNA和/或蛋白质的表达的化合物和方法。 这些方法可用于治疗癌症，例如结肠癌，肠癌，肺癌（例如非小细胞肺癌），肝癌和/或前列腺癌。 在各个方面，癌症是原发性癌症。
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7.发明申请MODULATION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 (STAT3) EXPRESSION 审中-公开信号传导器的调制和转录3（STAT3）表达的激活剂公开(公告)号：US20140336237A1
公开(公告)日：2014-11-13
申请号：US14338880
申请日：2014-07-23
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C07H21/00 , C07H21/04 , C12N15/00 , C12N15/11 , C12N15/1135 , C12N2310/11 , C12N2310/315 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/321 , C12N2310/3521 , C12N2310/3525
摘要： Disclosed herein are antisense compounds and methods for decreasing STAT3 mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate hyperproliferative diseases.
摘要翻译： 本文公开了用于降低STAT3 mRNA和蛋白质表达的反义化合物和方法。 这些方法，化合物和组合物可用于治疗，预防或改善过度增殖性疾病。
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