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公开(公告)号：US20240346735A1
公开(公告)日：2024-10-17
申请号：US18633750
申请日：2024-04-12
发明人： Luchuan Song , Chenliang Xu
CPC分类号： G06T13/40 , G06T3/18 , G06T7/20 , G06T7/70 , G06T17/20 , G06V10/44 , G06V40/174 , H04N21/816
摘要： Features described herein pertain to generative machine learning, and more particularly, to machine learning techniques for generating virtual characters. A video that depicts a first subject and includes an audio component that corresponds to speech spoken by the first subject and an image that depicts a second subject are provided to and used by one or more machine learning models to generate a video that depicts the second subject. The second subject can blink and exhibit emotional characteristic and reactions that are responsive to the speech spoken by the first subject and/or a characteristic of the first subject such as a facial expression and/or head pose motion. The generated video can be displayed and/or stored where it can be later retrieved.
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2.发明公开公开(公告)号：US20240342717A1
公开(公告)日：2024-10-17
申请号：US18607405
申请日：2024-03-15
IPC分类号： B01L3/00 , G01N1/40 , G01N33/537
CPC分类号： B01L3/502753 , G01N1/4077 , G01N33/537 , B01L2300/0681 , G01N2001/4088
摘要： Provided are methods, devices, and kits for the isolation and detection of one or more analytes of interest from a biological sample using microslit filter membranes. In various examples, the methods use capture particles and binding agents for specific recognition of one or more analytes of interest.
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公开(公告)号：US12096193B2
公开(公告)日：2024-09-17
申请号：US18341248
申请日：2023-06-26
CPC分类号： H04R3/14 , H04R3/04 , H04R7/045 , H04R9/06 , H04R17/00 , H04R2440/05 , H04R2440/07
摘要： Systems and methods of driving plate loudspeakers with different parameters based on frequency region in a way similar to typical cone driver crossover networks are described. These systems and methods may be implemented using arrays of independently controlled drivers which allow a designer to emphasize or de-emphasize certain modes in certain frequency bands. Tuning the characteristics of the plate's motion can also affect the acoustical properties in a larger space rather than just at a single location. The systems and methods described herein can grant a designer a degree of control over the characteristics and performance of the plate.
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公开(公告)号：US12083168B2
公开(公告)日：2024-09-10
申请号：US17719580
申请日：2022-04-13
IPC分类号： A61K38/44 , A61K31/198 , A61K31/352 , A61K31/4184 , A61K31/4188 , A61K31/426 , A61K31/428 , A61K31/473 , A61K31/499 , A61K31/502 , A61K31/517 , A61K31/7105 , A61K38/46 , A61K48/00 , A61P25/28 , C12N9/04 , C12N15/113 , C12N15/86 , C12Q1/6883 , G01N33/66
CPC分类号： A61K38/443 , A61K31/198 , A61K31/352 , A61K31/4184 , A61K31/4188 , A61K31/426 , A61K31/428 , A61K31/473 , A61K31/499 , A61K31/502 , A61K31/517 , A61K31/7105 , A61K38/465 , A61K48/005 , A61P25/28 , C12N9/0006 , C12N15/1137 , C12N15/86 , C12Q1/6883 , C12Y101/01014 , G01N33/66 , C12N2310/11 , C12N2750/14143 , C12Q2600/156
摘要： The present disclosure relates to methods of detecting and treating inherited neuropathy.
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公开(公告)号：US20240277868A1
公开(公告)日：2024-08-22
申请号：US18560828
申请日：2022-05-13
申请人： UNIVERSITY OF ROCHESTER , THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , ALBERT EINSTEIN COLLEGE OF MEDICINE
发明人： Vera GORBUNOVA , Andrei SELUANOV , Yousin SUH
CPC分类号： A61K48/0016 , A61K38/45 , A61P35/00 , A61P39/00 , C12N9/1029
摘要： An isolated nucleic acid molecule encoding a variant of sirtuin 6 (SIRT6) having at least 75% identity with sequence SEQ ID NO: 1, the variant having at least one mutation selected from a N308K substitution and a A313S substitution with respect to sequence SEQ ID NO: 1. Also, means for the regulation of ageing, and/or senescence, and/or lifespan in an individual. Further, means for the repair of double strand breaks in a cell. Finally, means for the prevention and/or the treatment of an age-related disease.
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6.发明公开公开(公告)号：US20240240205A1
公开(公告)日：2024-07-18
申请号：US18560338
申请日：2022-05-20
发明人： Brian M. WARD , Stephanie MONTICELLl , Peter BRYK
IPC分类号： C12N15/86 , A61K39/00 , A61K39/215 , A61P31/14
CPC分类号： C12N15/86 , A61K39/215 , A61P31/14 , A61K2039/5254 , A61K2039/5256
摘要： A method for inducing an immune response to an antigen in a subject is disclosed. The method comprises the step of administering to the subject an effective amount of a recombinant vaccinia virus in which the coding sequence for the extracellular virion protein F13 has been replaced with the coding sequence for MC021, a molluscum contagiosum virus homolog of F13, wherein the recombinant vaccinia virus comprises a nucleic acid encoding an immunogenic epitope of the antigen.
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公开(公告)号：US20240166603A1
公开(公告)日：2024-05-23
申请号：US18322187
申请日：2023-05-23
发明人： Paul Trippier , Paul Brookes , Xiaoyu Hao
IPC分类号： C07D213/69 , A61P35/00 , C07D213/74 , C07D491/056 , C07F9/58
CPC分类号： C07D213/69 , A61P35/00 , C07D213/74 , C07D491/056 , C07F9/58
摘要： The present invention includes molecules, composition, and methods for making and using a molecule having the formula:
wherein R′ is selected from H, methoxy, methoxymethyl, glycosyl, phosphoryl, alkylamine, polyethylene glycol (PEG), or deuterated; X is selected from OH, methoxy, methoxymethyl, O-methoxymethyl, carbonyl, or alcohol; Y is O; and R″ is selected from H, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, or dodecyl, that are saturated or unsaturated, PEG, or triphenylphosphate groups; optionally one or both MeO groups are deuterated; and N is N-oxide or N-alkyl.-
公开(公告)号：US20240133788A1
公开(公告)日：2024-04-25
申请号：US18535389
申请日：2023-12-11
CPC分类号： G01N15/0612 , B01D61/20 , B01D71/02 , B01D71/0215 , B01D2311/103 , G01N2015/0681 , G01N15/075
摘要： A device, system and method for the detection and screening of plastic microparticles in a sample is disclosed. A nanoporous silicon nitride membrane is used to entrap plastic microparticles contained in the sample. The sample may be a water sample, an air sample, or other liquid or gas sample. The entrapped plastic microparticles are then heated or otherwise processed on the nanoporous silicon nitride membrane. An imaging system observes the nanoporous silicon nitride membrane with the entrapped plastic microparticles to determine the type and quantity of the various plastic microparticles that are entrapped on the membrane.
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公开(公告)号：US11959841B2
公开(公告)日：2024-04-16
申请号：US16476329
申请日：2018-01-08
CPC分类号： G01N1/4005 , B01D69/02 , B01D71/02 , B01D71/52 , C12N15/1017 , B01D2325/027 , B01D2325/42 , G01N2001/4016
摘要： A device and method for isolating extracellular vesicles from biofluids is disclosed. A nanoporous silicon nitride membrane is provided with a tangential flow of biofluid. A pressure gradient through the nanoporous silicon nitride membrane facilitates capture of extracellular vesicles from the tangential flow vector of biofluid. Reversal of the pressure gradient results in the release of the extracellular vesicles for subsequent collection.
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10.发明公开公开(公告)号：US20240082952A1
公开(公告)日：2024-03-14
申请号：US18508756
申请日：2023-11-14
IPC分类号： B23K26/082 , B23K26/06 , B23K26/0622 , G02B13/00 , G02B26/10 , G02B27/00
CPC分类号： B23K26/082 , B23K26/0624 , B23K26/0648 , G02B13/0005 , G02B13/0095 , G02B26/101 , G02B26/105 , G02B27/0031
摘要： A pre-objective two-degree-of-freedom galvanometer scanning system including two galvo mirrors (111,112) with an optical relay (120) between the mirrors (111,112) and a microscope objective (130) with a curved image plane (140) is presented. The second galvo mirror (112) is located in the aperture stop before the objective. The optical system enables scanning in both directions over the full, curved field for creating custom refractive structures across the 6.5 mm optical zone of contact lenses using femtosecond micro-modification.
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